CD295 / Leptin Receptor antibody

Principal name

CD295 / Leptin Receptor antibody

Alternative names for CD295 / Leptin Receptor antibody

LEP-R, OB receptor, HuB219, LEPR, DB, OBR, OB-R

SwissProt ID

O02671 (Pig), P48356 (Mouse), P48357 (Human), Q62959 (Rat), Q9I8V6 (Chick)

Gene ID

3953 (LEPR), 16847 (Lepr), 24536

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Bov (Bovine), Chk (Chicken), Gt (Goat)

Available hosts

Rabbit, Mouse, Goat, Rat, Chicken

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of CD295 / Leptin Receptor antibody

Leptin is the adipocyte-specific product of the ob gene. Expression of leptin in fully fed animals reflects adipocyte size and body-fat mass. Leptin signals the status of body energy stores to the brain, where signals emanate to regulate food intake and whole-body energy expenditure. The leptin gene was identified in the leptindeficient, obese ob/ob mouse by positional cloning techniques. Recently, leptin has been cloned in domestic species including pigs, cattle, and chickens. The receptor for OB has been identified in mouse, human and rat. In mouse, the mature receptor is a 1142 aa residue, type I (extracellular N-terminal) transmembrane protein with a predicted molecular weight of 81 kDa. The molecule shows 817 aa residues in its extracellular segment, 21 aa residues in its transmembrane domain, and 302 aa residues in its cytoplasmic tail. Mouse, human and rat OB receptors are all virtually identical in length, with the mouse extracellular and cytoplasmic segments exhibiting 77% and 72% aa identity with their human counterparts. The OB receptor is described as being a gp130 analog. The leptin receptor has at least five splice variants; the long form of the receptor is primarily expressed in the hypothalamus and is thought to be the predominant signaling isoform. Leptin receptors are members of the cytokine family of receptors and signal via janus-activated kinases(JAK)/signal transducers and activators of transcription (STAT) and mitogen-activated protein kinase (MAPK) pathways. Mutations in the leptin or leptin receptor genes results in morbid obesity, infertility, and insulin resistance in rodents and humans. Leptin receptors are expressed in most tissues, and in vitro evidence suggests that leptin may have direct effects on some tissues such as adipose tissue, the adrenal cortex, and the pancreatic beta-cell. Leptin is thought to influence whole-body glucose homeostasis and insulin action.

General readings

Verhaeghe J, van Bree R, Van Herck E . Maternal body size 1. and birth weight: can insulin or adipokines do better. Metabolism . Mar;55(3):339-44 (2006)#
See: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WN4-4J8CNCM-F&_user=10&_coverDate=03/31/2006&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=17f15585dd6c2b2a160350b189379a59

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD295 / Leptin Receptor antibody

TA302673 (1µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, WB
20 µg / €200.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor antibody

TA302673 (1µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD295 / Leptin Receptor antibody

Predicted band size: 96 kDa . Positive control: HT-29 and K562 cell lysate. Recommended dilution: 1/200-1000 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD295 / Leptin Receptor antibody

Predicted cell location: Cytoplasm. Positive control: Human breast cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using LEPR antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD295 / Leptin Receptor (soluble) antibody

CD295 / Leptin Receptor Mouse IgG1 2F1 Purified Hu C, E, P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor (37-52) antibody

Figure 1. Staining LEPR in Liver by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor antibody

Immunohistochemistry (IHC) analyzes of Ob-R antibody (Cat.-No.: AP20585PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor (829-841) antibody

Human Heart (formalin-fixed, paraffin-embedded) stained with LEPR antibody AP22503PU-N at 4 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Can, Eq, Hu, Prim E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor antibody

CD295 / Leptin Receptor Mouse IgG1 LPR-02 Aff - Purified Hu C, E, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor antibody

CD295 / Leptin Receptor Mouse IgG1 LPR-01 Aff - Purified Hu C, E, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor antibody

CD295 / Leptin Receptor Rat IgG2 9C29 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor antibody

CD295 / Leptin Receptor Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CD295 / Leptin Receptor antibody

CD295 / Leptin Receptor Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

CD295 / Leptin Receptor antibody

CD295 / Leptin Receptor Mouse IgG1 2H5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD295 / Leptin Receptor antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with LEPR polyclonal antibody ( Cat # PAB4730 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P
0.4 ml / €390.00
  Abnova Taiwan Corp.

CD295 / Leptin Receptor antibody

LEPR polyclonal antibody ( Cat # PAB7037 ) ( 1 µg/ml ) staining of human brain lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CD295 / Leptin Receptor antibody

Western blot of both short and long forms of Lepr on mouse lung tissue extract using Lepr polyclonal antibody ( Cat # PAB13709 ). Rabbit Hu, Ms, Rt WB
0.1 ml / €900.00
  Abnova Taiwan Corp.

CD295 / Leptin Receptor antibody

Western blot analysis of extracts from COS7 cells, treated with calyculinA 50ng/ml 30', using Leptin Receptor (Ab-1141) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

CD295 / Leptin Receptor antibody

Western blot analysis of extracts from COS7 cells, treated with calyculinA 50ng/ml 30', using Leptin Receptor (Ab-1141) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €310.00
  Assay Biotech

CD295 / Leptin Receptor antibody

CD295 / Leptin Receptor Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

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