CD295 / Leptin Receptor antibody

Principal name

CD295 / Leptin Receptor antibody

Alternative names for CD295 / Leptin Receptor antibody

LEP-R, OB receptor, HuB219, LEPR, DB, OBR, OB-R

SwissProt ID

O02671 (Pig), P48356 (Mouse), P48357 (Human), Q62959 (Rat), Q9I8V6 (Chick)

Gene ID

3953 (LEPR), 16847 (Lepr), 24536

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), Prim (Primate), Bear

Available hosts

Mouse, Goat, Rabbit, Rat, Chicken

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD295 / Leptin Receptor antibody

Leptin receptor (OB R) was identified as a leptin binding protein (Leptin, the product of the ob gene, is a single chain 16 kDa protein consisting of 146 amino acid residues.) OB R was found to be a member of the class I cytokine receptor family with a large extracellular domain comprising 816 amino acid residues. Leptin receptor exists in multiple forms with a common extracellular domain and a variable length cytoplasmatic portion. Alternate splicing from a single gene derives the six isoforms of the Leptin receptor. The soluble form of the Leptin receptor, OB R contains no intracellular motifs or transmembrane residues, thus it consists entirely of the extracellular ligand binding domain of the receptor. Long forms of OB-R transcripts were reported to be expressed predominantly in regions of the hypothalamus which provides evidence that Leptin receptor is important in body weight regulation. Expression of short forms of OB-R transcripts have been found in multiple tissues, including the choroid plexus, lung, kidney, and primitive hematopoietic cell populations. Leptin receptor may act as a negative regulator of Leptin activity and it may maintain a pool of available bioactive Leptin by binding and delaying its clearance from circulation. Soluble Leptin receptor levels are indirectly proportional to adiposity and are increased in females versus males. Leptin receptor levels are highest in infants, decrease into adolescence, and remain relatively stable throughout adulthood. Soluble Leptin receptor is also found upregulated in patients with chronic heart failure, end-stage renal disease and anorexia.

General readings

Verhaeghe J, van Bree R, Van Herck E . Maternal body size 1. and birth weight: can insulin or adipokines do better. Metabolism . Mar;55(3):339-44 (2006)#
See: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WN4-4J8CNCM-F&_user=10&_coverDate=03/31/2006&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=17f15585dd6c2b2a160350b189379a59

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD295 / Leptin Receptor antibody

  Goat Polyclonal Antibody against Leptin Receptor  
TA302673 (1µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD295 / Leptin Receptor antibody

  Anti-LEPR Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human breast cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using LEPR antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD295 / Leptin Receptor (soluble) antibody

CD295 / Leptin Receptor Mouse IgG1 2F1 Purified Hu C, E, P, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor (37-52) antibody

Figure 1. Staining LEPR in Liver by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor antibody

Immunohistochemistry (IHC) analyzes of Ob-R antibody (Cat.-No.: AP20585PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor (829-841) antibody

Human Heart (formalin-fixed, paraffin-embedded) stained with LEPR antibody AP22503PU-N at 4 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Can, Eq, Hu, Prim E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor antibody

CD295 / Leptin Receptor Mouse IgG1 LPR-02 Aff - Purified Hu C, E, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor antibody

CD295 / Leptin Receptor Mouse IgG1 LPR-01 Aff - Purified Hu C, E, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor antibody

CD295 / Leptin Receptor Rat IgG2 9C29 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CD295 / Leptin Receptor antibody

Western blot analysis of extracts from COS7 cells, treated with calyculinA 50ng/ml 30', using Leptin Receptor (Ab-1141) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €230.00
  Assay Biotech

CD295 / Leptin Receptor antibody

Western blot analysis of extracts from COS7 cells, treated with calyculinA 50ng/ml 30', using Leptin Receptor (Ab-1141) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €330.00
  Assay Biotech

CD295 / Leptin Receptor (LepRb / OBRb) antibody

LepRb staining in rat intestine.Detection was done using anti-chicken Cy2 conjugated antibodies (green color). Cell nuclei were counterstained with DAPI (blue color). Working dilution is 1:200-1:600.  Chicken Aff - Purified Rt C, ICC/IF, WB
0.1 ml / €290.00
  Neuromics Antibodies

CD295 / Leptin Receptor antibody

Leptin Receptor Staining of Cryostat tissue sections of rat brain  with HRP-DAB  (brown) and Haematoxylin (blue). Goat Aff - Purified Ms, Rt C, E, P, WB
0.1 mg / €450.00
  Neuromics Antibodies

CD295 / Leptin Receptor antibody

Leptin Receptor Staining of paraffin embedded tissue sections of human brain  with HRP-DAB  (brown) and Haematoxylin (blue). Goat IgG2 Aff - Purified Hu C, E, WB
0.1 mg / €450.00
  Neuromics Antibodies

CD295 / Leptin Receptor (e form) (25-208) antibody

CD295 / Leptin Receptor Rabbit Purified Ms WB
0.2 mg / €290.00
  Torrey Pines Biolabs

CD295 / Leptin Receptor (e form) (25-208) antibody

CD295 / Leptin Receptor Rabbit Azide Free Ms WB
0.2 mg / €290.00
  Torrey Pines Biolabs

CD295 / Leptin Receptor (e form) (217-376) antibody

CD295 / Leptin Receptor Rabbit Purified Ms WB
0.2 mg / €290.00
  Torrey Pines Biolabs

CD295 / Leptin Receptor (e form) (217-376) antibody

CD295 / Leptin Receptor Rabbit Azide Free Ms WB
0.2 mg / €290.00
  Torrey Pines Biolabs

CRISPR

Catalog No. Species Donor Vector  

LEPR - human gene knockout kit via CRISPR

LEPR - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

LEPR - human gene knockout kit via CRISPR

LEPR - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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