CD299 / CLEC4M antibody

Principal name

CD299 / CLEC4M antibody

Alternative names for CD299 / CLEC4M antibody

CD209L, CD209L1, C-type lectin domain family 4 member M, CD209 antigen-like protein 1, Dendritic cell-specific ICAM-3-grabbing non-integrin 2, DC-SIGN-related protein, Liver/lymph node-specific ICAM-3-grabbing non-integrin

SwissProt ID

Q9H2X3 (Human)

Gene ID

10332 (CLEC4M)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Neutralisation (NEUT)

Background of CD299 / CLEC4M antibody

CLEC4M is a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.This gene encodes a type II integral membrane protein that is 77% identical to CD209 antigen, a HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

General readings

Liu,H., (2006) J. Infect. Dis. 193 (5), 698-702

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD299 / CLEC4M antibody

CD299 / CLEC4M Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CD299 / CLEC4M antibody

CD299 / CLEC4M Mouse IgG3 2G1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD299 / CLEC4M antibody

Human Muscle; WB Suggested Anti-CLEC4M Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Muscle; CLEC4M antibody - N-terminal region (ARP42395_P050) in Human Muscle cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

CD299 / CLEC4M antibody

Human kidney; CLEC4M antibody - N-terminal region (ARP42396_T100) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified Hu P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

CD299 / CLEC4M antibody

CD299 / CLEC4M Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

CD299 / CLEC4M antibody

CD299 / CLEC4M Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

CD299 / CLEC4M antibody

Western Blot: CLEC4M Antibody [NBP1-59181] - This Anti-CLEC4M antibody was used in Western Blot of Fetal Muscle tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

CD299 / CLEC4M antibody

Western Blot: CLEC4M Antibody [NBP1-59182] - This Anti-CLEC4M antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 1.25ug/ml. Rabbit Purified Hu P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

CD299 / CLEC4M antibody

Western Blot: CLEC4M Antibody [NBP1-59183] - This Anti-CLEC4M antibody was used in Western Blot of Fetal Kidney    tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD299 / CLEC4M (transcript variant 1)

CD299 / CLEC4M Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CD299 / CLEC4M

CD299 / CLEC4M Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CD299 / CLEC4M

CD299 / CLEC4M Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CLEC4M overexpression lysate

CLEC4M overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

13 Item(s)

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