CD30 antibody

Principal name

CD30 antibody

Alternative names for CD30 antibody

TNFRSF8, D1S166E, CD30L receptor, KI-1 antigen, Tumor necrosis factor receptor superfamily member 8, Lymphocyte activation antigen CD30

SwissProt ID

P28908 (Human), P97525 (Rat), Q60846 (Mouse)

Gene ID

21941 (Tnfrsf8), 943 (TNFRSF8), 9332 (CD163)

Available reactivities

Ms (Mouse), Hu (Human), Mky (Monkey), Rt (Rat)

Available hosts

Rat, Mouse, Goat, Hamster, Rabbit

Available applications

Enzyme Immunoassay (E), Flow Cytometry (F), Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD30 antibody

Characterization of the CD30 antigen has shown it to be in its mature form a transmembrane protein of about 120kDa elaborated from an 84kD cytoplasmic precursor primarily through glycosylation. The CD30 ligand (CD30L) has been identified, showing significant homology to TNF-alpha, TNF-beta, FasL, CD40L, CD27L and 4-1BBl. CD30L is expressed on activated T-cells. Interactions of the cytokine receptor CD30 with its ligand induces pleiotropic biologic effects, such as differentiation, activation, proliferation and cell death. CD30 expression is strictly dependent on activation and proliferation of T- and B-cells. In pathological conditions, CD30 positivity is regarded as a peculiar attribute of Hodgkin's and Reed-Sternberg cells. An 85kDa soluble form of the CD30 molecule (sCD30) has been shown to be released by CD30+ cell in vitro and in vivo. Increased serum levels of sCD30 have been reported for patients with CD30+ ALCL and CD30+ embryonal carcinoma of the testis and were found to correlate with the clinical phase of the disease, i.e. presentation complete remission (CR), relapse.

General readings

1. Blazar BR, Levy RB, Mak TW, Panoskaltsis-Mortari A, Muta H, Jones M, Roskos M, Serody JS, Yagita H, Podack ER, Taylor PA: CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease. J Immunol. 2004 Sep
1;173(5):2933-41.
2. Fischer M, Harvima IT, Carvalho RF, Möller C, Naukkarinen A, Enblad G, Nilsson G: Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. J Clin Invest. 2006 Oct;116(10):2748-56.
3. Kennedy MK, Willis CR, Armitage RJ: Deciphering CD30 ligand biology and its role in humoral immunity. Immunology. 2006 Jun;118(2):143-52.
4. Polte T, Behrendt AK, Hansen G: Direct evidence for a critical role of CD30 in the development of allergic asthma. J Allergy Clin Immunol. 2006 Oct;118(4):942-8.
5. Bekiaris V, Withers D, Glanville SH, McConnell FM, Parnell SM, Kim MY, Gaspal FM, Jenkinson E, Sweet C, Anderson G, Lane PJ: Role of CD30 in B/T segregation in the
spleen. J Immunol. 2007 Dec 1;179(11):7535-43.
6. Kusanovic JP, Romero R, Hassan SS, Gotsch F, Edwin S, Chaiworapongsa T, Erez O, Mittal P, Mazaki-Tovi S, Soto E, Than NG, Friel LA, Yoon BH, Espinoza J: Maternal serum
soluble CD30 is increased in normal pregnancy, but decreased in preeclampsia and small for gestational age pregnancies. J Matern Fetal Neonatal Med. 2007 Aug 28;:1-12
7. Zeiser R, Nguyen VH, Hou JZ, Beilhack A, Zambricki E, Buess M, Contag CH, Negrin RS: Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease. Blood. 2007 Mar 1;109(5):2225-33.
8. Wright CW, Rumble JM, Duckett CS: CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. J Biol Chem. 2007 Apr;282(14):10252-62.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD30 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TNFRSF8 mouse monoclonal antibody. (TA801630) Mouse IgG1 OTI1C6 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD30 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-TNFRSF8 mouse monoclonal antibody. (TA801647) Mouse IgG2a OTI18D3 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD30 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TNFRSF8 mouse monoclonal antibody. (TA801685) Mouse IgG1 OTI16H5 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD30 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-TNFRSF8 mouse monoclonal antibody. (TA801686) Mouse IgG1 OTI9H7 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD30 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-TNFRSF8 mouse monoclonal antibody. (TA804018) Mouse IgG1 OTI3A2 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD30 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TNFRSF8 mouse monoclonal antibody. (TA804021) Mouse IgG1 OTI2G7 Purified Hu F, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD30 antibody

Western blot analysis using CD30 mAb against human CD30 (AA: 536-590) recombinant protein. (Expected MW is 32 kDa) Mouse IgG1 3B10 Ascites Hu E, F, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

CD30 antibody

Immunohistochemistry: AM20190AF-N CD30 antibody staining of Paraffin Embedded CCRF-CEM Section. Mouse IgG1 Ber-H2 Azide Free Hu F, IP, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CD30 antibody

Formalin-Fixed, Paraffin-Embedded Hodgkin's lymphoma (20X) stained with CD30 Antibody Cat.-No AM32849PU (Clone CD30/412). Mouse IgG2b CD30/412 Purified Hu C, F, ICC/IF, IP, P
0.2 mg / €390.00
  Acris Antibodies GmbH

CD30 antibody

Formalin-Fixed, Paraffin-Embedded Hodgkin's lymphoma (20X) stained with CD30 Antibody Cat.-No AM32849PU (Clone CD30/412). Mouse IgG2b CD30/412 Purified Hu C, F, ICC/IF, IP, P
0.1 mg / €320.00
  Acris Antibodies GmbH

CD30 antibody

Formalin-Fixed, Paraffin-Embedded Hodgkin's lymphoma (20X) stained with CD30 Antibody Cat.-No AM32849PU (Clone CD30/412). Mouse IgG2b CD30/412 Purified Hu C, F, ICC/IF, IP, P
20 µg / €160.00
  Acris Antibodies GmbH

CD30 antibody

CD30 Hamster mCD30.1 Purified Ms F
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD30 antibody

Immunohistochemistry staining of Paraffin Classic Hodgkin lymphoma tissue by CD30 antibody (dilution: 1:50 - 1:200; visualization of staining: Membranous) Mouse IgG1 Ber-H2 Purified Hu P
1 ml / €580.00
  OriGene Technologies, Inc.

CD30 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-TNFRSF8 rabbit polyclonal antibody. (TA590389) Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD30 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF8 (RC219819, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF8. Mouse IgG2a OTI2G2 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD30 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-TNFRSF8 mouse monoclonal antibody. (TA801726) Mouse IgG1 OTI3B5 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD30 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF8 (RC219819, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF8. Mouse IgG1 OTI4B3 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD30 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF8 (RC219819, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF8. Mouse IgG1 OTI3B10 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD30 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF8 (RC219819, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF8. Mouse IgG1 OTIF8 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD30 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TNFRSF8 (RC219819, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TNFRSF8. Mouse IgG2b OTI1G2 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Items 1 to 20 of 77 total

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