CD31 / PECAM1 antibody

Principal name

CD31 / PECAM1 antibody

Alternative names for CD31 / PECAM1 antibody

PECAM-1, EndoCAM, GPIIA', Platelet endothelial cell adhesion molecule

SwissProt ID

P16284 (Human), P51866 (Bovin), Q08481 (Mouse), Q3SWT0 (Rat), Q95242 (Pig)

Gene ID

5175 (PECAM1), 18613 (Pecam1), 29583, 396941

Available reactivities

Hu (Human), Ms (Mouse), Mky (Monkey), Rt (Rat), Rhesus Mky (Rhesus Monkey), Bov (Bovine), Sh (Sheep), Por (Porcine), Gt (Goat), Rb (Rabbit), Can (Canine), Bab (Baboon)

Available hosts

Mouse, Rat, Hamster, Rabbit, Sheep, Goat

Available applications

Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), Immunoprecipitation (IP), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Luminex (LMNX)

Selected product citations ‐ of AP15436PU-S

1. Moghadamrad S, McCoy KD, Geuking MB, Sägesser H, Kirundi J, Macpherson AJ, et al. Attenuated portal hypertension in germ-free mice: Function of bacterial flora on the development of mesenteric lymphatic and blood vessels. Hepatology. 2015 Jan 16. doi: 10.1002/hep.27698. PubMed PMID: 25643846. 
2. Pfankuche, VM;Spitzbarth, I;Lapp, S;Ulrich, R;Deschl, U;Kalkuhl, A;Baumgärtner, W;Puff, C. Reduced angiogenic gene expression in morbillivirus-triggered oncolysis in a translational model for histiocytic sarcomaJ. Cell. Mol. Med. 2016. PubMed PMID:  27860224.

Background of CD31 / PECAM1 antibody

Platelet endothelial cell adhesion molecule-1 (PECAM-1) or cluster designation 31 (CD31) is a member of the immunoglobulin (Ig) gene superfamily and a transmembrane glycoprotein. The CD31 protein is widely expressed by cells of the vascular endothelium lineage, platelets, Kupffer cells, granulocytes, megakaryocytes, monocytes, neutrophils, and some types of T-cells. CD31 functions as a cell adhesion molecule in endothelial cell homotypic interactions in the process of angiogenesis. CD31 is also involved in leukocyte migration and integrin activation. It plays a key role in the adhesion cascade between the endothelial cells and inflammatory cells, enabling leukocyte migration in inflammatory sites. CD31 is one of the best markers for benign and malignant vascular tumors. It is expressed in certain tumors including angiomas and angiosarcomas including epitheloid hemangioendothelioma, epitheloid sarcoma-like hemangioendothelioma. Its expression in Kaposi sarcoma lesions is variable. Human CD31 comprises 738 amino acids and its predicted molecular weight would therefore be approximately 81kDa. However the observed molecular weight, as reported by various research groups including our own, is higher and at around 120kDa and 140kDa. The disparity probably reflects post translational modifications including glycosylation and probably because different isoforms of the protein may exist.

General readings

1. Williams KC, Zhao RW, Ueno K, Hickey WF. PECAM-1 (CD31) expression in the central nervous system and its role in experimental allergic encephalomyelitis in the rat. J Neurosci Res. 1996 Sep 15;45(6):747-57. PubMed PMID: 8892086.
2. Nakao, A. et al. (2003) Carbon monoxide inhalation protects rat intestinal grafts from ischemia / reperfusion injury. Am J Pathol. 163: 1587-98.
3. Stevenson, K.S. et al. (2009) Isolation, characterization, and differentiation of thy1.1-sorted pancreatic adult progenitor cell populations. Stem Cells Dev. 18: 1389-98.
4. Ott, I. et al. (2005) Endothelial-like cells expanded from CD34+ blood cells improve left ventricular function after experimental myocardial infarction. FASEB J. 19: 992-4.
5. Fujimoto, K.L. et al. (2007) An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in subacute myocardial infarction. J Am Coll Cardiol. 49: 2292-300.
6. Thebault, P. et al. (2010) The C-type lectin-like receptor CLEC-1, expressed by myeloid cells and endothelial cells, is up-regulated by immunoregulatory mediators and moderates T cell activation. J Immunol. 183: 3099-108.
7. Graham, M.J. et al. (1998) In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration. J Pharmacol Exp Ther. 286:447-58.
8. Haywood, L. et al. (2003) Inflammation and angiogenesis in osteoarthritis. Arthritis Rheuma48: 2173-7.
9. Kielian, T. and Hickey, W.F. (2010) Proinflammatory cytokine, chemokine, and cellular adhesion molecule expression during the acute phase of experimental brain abscess development. Am J Pathol. 157: 647-58.
10. Lochhead, J.J. et al. (2010) Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation. J Cereb Blood Flow Metab. 30:
1625-36.11. Arkudas, A. et al. (2007) Fibrin gel-immobilized VEGF and bFGF efficiently stimulate angiogenesis in the AV loop model. Mol Med. 13: 480-7.
12. Nakao, A. et al. (2011) Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts. Cardiovasc Res. 89: 457-63.
13. Ohnishi, T. et al. (2007) Comparison of endothelial cell proliferation in normal liver and adipose tissue in B6C3F1 mice, F344 rats, and humans. Toxicol Pathol. 35: 904-9.
14. Schilte, M.N. et al. (2009) Long-term intervention with heparins in a rat model of peritoneal dialysis. Perit Dial Int. 29: 26-35.
15. Seegers, H.C. et al. (2003) Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation. J Pharmacol Exp Ther. 306:8-12.
16. Wilson, E. et al. (2007) An evaluation of the immunohistochemistry benefits of boric acid antigen retrieval on rat decalcified joint tissues. J Immunol Methods. 322: 137-42.
17. Willis, C.L. et al. (2010) Protein kinase C activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and posthypoxic reoxygenation. J Cereb Blood Flow Metab. 30: 1847-59.
18. Salehi-Had, H. et al. (2011) Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization. PLoS One. 6: e18864.
19. MacLean, A.G. et al. (2001) Rhesus macaque brain microvessel endothelial cells behave in a manner phenotypically distinct from umbilical vein endothelial cells. J Neuroimmunol. 118: 223-32.
20. Ceelen, W. et al. (2007) Recombinant human erythropoietin alpha modulates the effects of radiotherapy on colorectal cancer microvessels. Br J Cancer. 96: 692-700.
21. Tung, H.C. et al. (2015) The Beneficial Effects of P2X7 Antagonism in Rats with Bile Duct Ligation-induced Cirrhosis. PLoS One. 10 (5): e0124654.
22. Oboshi, M. et al. (2015) Temporary dietary iron restriction affects the process of thrombus resolution in a rat model of deep vein thrombosis. PLoS One. 10 (5): e0126611.
23. Wu, S.H. et al. (2015) Autologous adipose-derived stem cells attenuate muscular atrophy and protect spinal cord ventral horn motor neurons in an animal model of burn injury.Cytotherapy. 17 (8): 1066-75.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD31 / PECAM1 antibody

  anti-PECAM1 (CD31) mouse monoclonal antibody, clone OTI8A9 (formerly 8A9)  
Immunohistochemical staining of paraffin-embedded lung within the normal limits using anti-PECAM1 (TA000121) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min). Mouse IgG2a OTI8A9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD31 / PECAM1 antibody

  PECAM1 (CD31) mouse monoclonal antibody, clone OTI1H6 (formerly 1H6)  
Anti-PECAM1 mouse monoclonal antibody (TA504773) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PECAM1(RC208654). Mouse IgG1 OTI1H6 Purified Can, Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD31 / PECAM1 antibody

Immunohistochemical staining on Mouse Kidney Frozen Sections using CD31 antibody clone ER-MP12 Cat.-No BM4086B. Rat IgG2a ER-MP12 Purified Ms C, F, P
0.1 mg / €480.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Figure 3. BM4047 CD31 antibody staining of Human Placenta Paraffin Section. Mouse IgG1 MEM-05 Hu C, F, P
0.2 mg / €310.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Surface staining of human peripheral blood with anti-human CD31 (MEM-05) biotin. Mouse IgG1 MEM-05 APC Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Surface staining of lysed and washed human peripheral blood with purified anti-human CD31 (MEM-05) (detection by Goat anti-mouse IgG1 PE). Mouse IgG1 MEM-05 Biotin Hu F
0.1 mg / €260.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Surface staining of human peripheral blood with anti-human CD31 (MEM-05) biotin. Mouse IgG1 MEM-05 FITC Hu F
100 Tests / €260.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Surface staining of human peripheral blood with anti-human CD31 (MEM-05) biotin. Mouse IgG1 MEM-05 PE Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Surface staining of lysed and wash human peripheral blood with purified anti-Human CD31 antibody (MEM-05) (detection by Goat anti-mouse IgG1 PE). Mouse IgG1 MEM-05 Purified Hu F, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Immunohistochemical staining on Mouse Kidney Frozen Sections using CD31 antibody clone ER-MP12 Cat.-No BM4086B. Rat IgG2a ER-MP12 Biotin Ms C, F, P
0.3 mg / €500.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

  PECAM1 mouse monoclonal antibody,clone UMAB29  
Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-PECAM1mouse monoclonal antibody. (Clone UMAB29, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB29 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD31 / PECAM1 antibody

  PECAM1 mouse monoclonal antibody,clone UMAB30  
CD31 / PECAM1 Mouse IgG1 UMAB30 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD31 / PECAM1 antibody

  PECAM1 mouse monoclonal antibody,clone UMAB31  
Immunohistochemical staining of paraffin-embedded prostate tissue using anti-PECAM1mouse monoclonal antibody. (Clone UMAB31, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB31 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD31 / PECAM1 antibody

  PECAM1 mouse monoclonal antibody,clone UMAB32  
Immunohistochemical staining of paraffin-embedded Carcinoma of prostate tissue using anti-PECAM1mouse monoclonal antibody. (Clone UMAB32, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB32 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD31 / PECAM1 antibody

  PECAM1 mouse monoclonal antibody,clone UMAB164  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PECAM1 mouse monoclonal antibody. (UM500106, heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG1 UMAB164 Purified Hu P
0.1 ml / €379.00
  OriGene Technologies, Inc.

UltraMAB

CD31 / PECAM1 antibody

  PECAM1 mouse monoclonal antibody,clone UMAB29  
Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-PECAM1mouse monoclonal antibody. (Clone UMAB29, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB29 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD31 / PECAM1 antibody

  PECAM1 mouse monoclonal antibody,clone UMAB30  
CD31 / PECAM1 Mouse IgG1 UMAB30 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD31 / PECAM1 antibody

  PECAM1 mouse monoclonal antibody,clone UMAB31  
Immunohistochemical staining of paraffin-embedded prostate tissue using anti-PECAM1mouse monoclonal antibody. (Clone UMAB31, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB31 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD31 / PECAM1 antibody

  PECAM1 mouse monoclonal antibody,clone UMAB32  
Immunohistochemical staining of paraffin-embedded Carcinoma of prostate tissue using anti-PECAM1mouse monoclonal antibody. (Clone UMAB32, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB32 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD31 / PECAM1 antibody

  PECAM1 mouse monoclonal antibody,clone UMAB164  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PECAM1 mouse monoclonal antibody. (UM500106, heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG1 UMAB164 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

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