CD31 / PECAM1 antibody

Principal name

CD31 / PECAM1 antibody

Alternative names for CD31 / PECAM1 antibody

PECAM-1, EndoCAM, GPIIA', Platelet endothelial cell adhesion molecule

SwissProt ID

P16284 (Human), P51866 (Bovin), Q08481 (Mouse), Q3SWT0 (Rat), Q95242 (Pig)

Gene ID

5175 (PECAM1), 18613 (Pecam1), 29583, 396941, 9332 (CD163)

Available reactivities

Hu (Human), Ms (Mouse), Rb (Rabbit), Mky (Monkey), Rt (Rat), Rhesus Mky (Rhesus Monkey), Bov (Bovine), Sh (Sheep), Por (Porcine), Gt (Goat), Can (Canine)

Available hosts

Mouse, Rat, Hamster, Rabbit, Sheep, Goat

Available applications

Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), Immunoprecipitation (IP), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Luminex (LMNX)

Background of CD31 / PECAM1 antibody

This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Type I membrane protein. SIZE: 738 amino acids; 82536 Da. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Long isoform predominates all tissues examined, isoform Delta12 was detected only in trachea and isoform Delta14-15 only in lung, isoform Delta14 was detected in all tissues examined with the strongest expression in heart. PTM: Phosphorylated on Ser and Tyr residues after cellular activation. SIMILARITY: Contains 6 Ig-like C2-type (immunoglobulin-like) domains.CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. CD31 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Tyr-690 plays a critical role in leukocyte transendothelial migration (TEM) and is required for efficient trafficking of CD31 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. CD31 prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of CD31 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of CD31 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas).

General readings

1. Williams KC, Zhao RW, Ueno K, Hickey WF. PECAM-1 (CD31) expression in the central nervous system and its role in experimental allergic encephalomyelitis in the rat. J Neurosci Res. 1996 Sep 15;45(6):747-57. PubMed PMID: 8892086.
2. Nakao, A. et al. (2003) Carbon monoxide inhalation protects rat intestinal grafts from ischemia / reperfusion injury. Am J Pathol. 163: 1587-98.
3. Stevenson, K.S. et al. (2009) Isolation, characterization, and differentiation of thy1.1-sorted pancreatic adult progenitor cell populations. Stem Cells Dev. 18: 1389-98.
4. Ott, I. et al. (2005) Endothelial-like cells expanded from CD34+ blood cells improve left ventricular function after experimental myocardial infarction. FASEB J. 19: 992-4.
5. Fujimoto, K.L. et al. (2007) An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in subacute myocardial infarction. J Am Coll Cardiol. 49: 2292-300.
6. Thebault, P. et al. (2010) The C-type lectin-like receptor CLEC-1, expressed by myeloid cells and endothelial cells, is up-regulated by immunoregulatory mediators and moderates T cell activation. J Immunol. 183: 3099-108.
7. Graham, M.J. et al. (1998) In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration. J Pharmacol Exp Ther. 286:447-58.
8. Haywood, L. et al. (2003) Inflammation and angiogenesis in osteoarthritis. Arthritis Rheuma48: 2173-7.
9. Kielian, T. and Hickey, W.F. (2010) Proinflammatory cytokine, chemokine, and cellular adhesion molecule expression during the acute phase of experimental brain abscess development. Am J Pathol. 157: 647-58.
10. Lochhead, J.J. et al. (2010) Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation. J Cereb Blood Flow Metab. 30:
1625-36.11. Arkudas, A. et al. (2007) Fibrin gel-immobilized VEGF and bFGF efficiently stimulate angiogenesis in the AV loop model. Mol Med. 13: 480-7.
12. Nakao, A. et al. (2011) Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts. Cardiovasc Res. 89: 457-63.
13. Ohnishi, T. et al. (2007) Comparison of endothelial cell proliferation in normal liver and adipose tissue in B6C3F1 mice, F344 rats, and humans. Toxicol Pathol. 35: 904-9.
14. Schilte, M.N. et al. (2009) Long-term intervention with heparins in a rat model of peritoneal dialysis. Perit Dial Int. 29: 26-35.
15. Seegers, H.C. et al. (2003) Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation. J Pharmacol Exp Ther. 306:8-12.
16. Wilson, E. et al. (2007) An evaluation of the immunohistochemistry benefits of boric acid antigen retrieval on rat decalcified joint tissues. J Immunol Methods. 322: 137-42.
17. Willis, C.L. et al. (2010) Protein kinase C activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and posthypoxic reoxygenation. J Cereb Blood Flow Metab. 30: 1847-59.
18. Salehi-Had, H. et al. (2011) Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization. PLoS One. 6: e18864.
19. MacLean, A.G. et al. (2001) Rhesus macaque brain microvessel endothelial cells behave in a manner phenotypically distinct from umbilical vein endothelial cells. J Neuroimmunol. 118: 223-32.
20. Ceelen, W. et al. (2007) Recombinant human erythropoietin alpha modulates the effects of radiotherapy on colorectal cancer microvessels. Br J Cancer. 96: 692-700.
21. Tung, H.C. et al. (2015) The Beneficial Effects of P2X7 Antagonism in Rats with Bile Duct Ligation-induced Cirrhosis. PLoS One. 10 (5): e0124654.
22. Oboshi, M. et al. (2015) Temporary dietary iron restriction affects the process of thrombus resolution in a rat model of deep vein thrombosis. PLoS One. 10 (5): e0126611.
23. Wu, S.H. et al. (2015) Autologous adipose-derived stem cells attenuate muscular atrophy and protect spinal cord ventral horn motor neurons in an animal model of burn injury.Cytotherapy. 17 (8): 1066-75.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD31 / PECAM1 antibody

Immunohistochemical staining of paraffin-embedded lung within the normal limits using anti-PECAM1 (TA000121) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min). Mouse IgG2a OTI8A9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD31 / PECAM1 antibody

Anti-PECAM1 mouse monoclonal antibody (TA504773) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PECAM1(RC208654). Mouse IgG1 OTI1H6 Purified Can, Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD31 / PECAM1 antibody

Immunohistochemical staining on Mouse Kidney Frozen Sections using CD31 antibody clone ER-MP12 Cat.-No BM4086B. Rat IgG2a ER-MP12 Purified Ms C, F, P
0.1 mg / €480.00
  Acris Antibodies GmbH

CD31 / PECAM1 (C-term) antibody

Human Cervix stained with anti-CD31 antibody Cat.-No AM11103PU Rabbit IgG SP38 Supernatant Hu, Ms P
0.5 ml / €520.00
  Acris Antibodies GmbH

CD31 / PECAM1 (C-term) antibody

Human Cervix stained with anti-CD31 antibody Cat.-No AM11103PU Rabbit IgG SP38 Supernatant Hu, Ms P
1 ml / €750.00
  Acris Antibodies GmbH

CD31 / PECAM1 (C-term) antibody

Human Cervix stained with anti-CD31 antibody Cat.-No AM11103PU Rabbit IgG SP38 Supernatant Hu, Ms P
0.1 ml / €290.00
  Acris Antibodies GmbH

CD31 / PECAM1 (C-term) antibody

AP15436PU CD31 antibody staining of Human Tonsil. Rabbit Purified Hu, Ms, Por P
0.5 ml / €360.00
  Acris Antibodies GmbH

CD31 / PECAM1 (C-term) antibody

AP15436PU CD31 antibody staining of Human Tonsil. Rabbit Purified Hu, Ms, Por P
1 ml / €490.00
  Acris Antibodies GmbH

CD31 / PECAM1 (C-term) antibody

AP15436PU CD31 antibody staining of Human Tonsil. Rabbit Aff - Purified Hu, Ms, Por P
0.1 ml / €180.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Figure 3. BM4047 CD31 antibody staining of Human Placenta Paraffin Section. Mouse IgG1 MEM-05 Hu C, F, P
0.2 mg / €310.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Surface staining of human peripheral blood with anti-human CD31 (MEM-05) biotin. Mouse IgG1 MEM-05 APC Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Surface staining of lysed and washed human peripheral blood with purified anti-human CD31 (MEM-05) (detection by Goat anti-mouse IgG1 PE). Mouse IgG1 MEM-05 Biotin Hu F
0.1 mg / €260.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Surface staining of human peripheral blood with anti-human CD31 (MEM-05) biotin. Mouse IgG1 MEM-05 FITC Hu F
100 Tests / €260.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Surface staining of human peripheral blood with anti-human CD31 (MEM-05) biotin. Mouse IgG1 MEM-05 PE Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Surface staining of lysed and wash human peripheral blood with purified anti-Human CD31 antibody (MEM-05) (detection by Goat anti-mouse IgG1 PE). Mouse IgG1 MEM-05 Purified Hu F, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Immunohistochemical staining on Mouse Kidney Frozen Sections using CD31 antibody clone ER-MP12 Cat.-No BM4086B. Rat IgG2a ER-MP12 Biotin Ms C, F, P
0.3 mg / €500.00
  Acris Antibodies GmbH

CD31 / PECAM1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-PECAM1mouse monoclonal antibody. (Clone UMAB29, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB29 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD31 / PECAM1 antibody

CD31 / PECAM1 Mouse IgG1 UMAB30 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD31 / PECAM1 antibody

Immunohistochemical staining of paraffin-embedded prostate tissue using anti-PECAM1mouse monoclonal antibody. (Clone UMAB31, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB31 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD31 / PECAM1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of prostate tissue using anti-PECAM1mouse monoclonal antibody. (Clone UMAB32, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB32 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

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