CD314 / KLRK1 antibody

Principal name

CD314 / KLRK1 antibody

Alternative names for CD314 / KLRK1 antibody

D12S2489E, NKG2D, NK cell receptor D, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, Killer cell lectin-like receptor subfamily K member 1

SwissProt ID

O54709 (Mouse), O70215 (Rat), P26718 (Human), Q9GLF5 (Pig)

Gene ID

100528032 (KLRC4-KLRK1), 22914 (KLRK1), 27007 (Klrk1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Hamster, Rat, Rabbit

Available applications

Functional assay (FN), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of CD314 / KLRK1 antibody

NKG2D is a homodimeric C-type lectin-like protein also known as CD314. It is expressed on NK cells, CD8+ T cells, gamma/ delta T cells, and in vitro induced LAK cells. Several molecules have been identified as the ligands for NKG2D, including MHC class-I chain-related protein A (MICA), MICB, UL16-binding proteins (ULBPs). NKG2D has no intrinsic signaling capacity, but attains this by non-covalent association with DAP10 or DAP12 adaptors. In addition to be a primary activation receptor on NK cells, NKG2D is also a costimulatory receptor for TCR-mediated T cell proliferation and cytokine production. The interaction of NKG2D with its ligands plays a role in the immune surveillance against pathogen and tumor cells, and in the pathogenesis of autoimmune diseases. The 1D11 antibody blocks MICA binding to T cells, induces redirected lysis, and costimulates T cells activation and proliferation.

General readings

Hayakawa Y, Smyth MJ. Innate immune recognition and suppression of tumors. Adv Cancer Res. 2006;95:293-322

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD314 / KLRK1 antibody

TA303045 staining (0.3µg/ml) of human spleen lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
20 µg / €200.00
  Acris Antibodies GmbH

CD314 / KLRK1 antibody

TA303045 staining (0.3µg/ml) of human spleen lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD314 / KLRK1 antibody

NKG2D antibody [N3C2], Internal detects NKG2D protein at cytosol on human lung carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human lung carcinoma. NKG2D antibody [N3C2], Internal (TA308267) dilution: 1:250. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD314 / KLRK1 antibody

Two-color surface staining of mouse splenocytes with Anti-Mouse CD314 (NKG2D) PE and Anti-Mouse NK1.1 APC.  Total viable cells were used for analysis. Rat CX5 Purified Ms F
50 µg / €120.00
  OriGene Technologies, Inc.

CD314 / KLRK1 antibody

CD314 / KLRK1 Mouse IgG1 1D11 FITC Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD314 / KLRK1 antibody

CD314 / KLRK1 Mouse IgG1 1D11 FITC Hu F
25 µg / €190.00
  Acris Antibodies GmbH

CD314 / KLRK1 antibody

CD314 / KLRK1 Mouse IgG1 1D11 Low Endotoxin Hu C, F, FN, IP
0.5 mg / €540.00
  Acris Antibodies GmbH

CD314 / KLRK1 antibody

Staining of human peripheral blood lymphocytes with Mouse Anti Human CD314 (SM2260P/PT) Mouse IgG1 1D11 Purified Hu C, F, IP
0.2 mg / €480.00
  Acris Antibodies GmbH

CD314 / KLRK1 antibody

Staining of human peripheral blood lymphocytes with Mouse Anti Human CD314 (SM2260P/PT) Mouse IgG1 1D11 Purified Hu C, F, IP
25 µg / €180.00
  Acris Antibodies GmbH

CD314 / KLRK1 antibody

CD314 / KLRK1 Mouse IgG1 1D11 PE Hu F
100 Tests / €480.00
  Acris Antibodies GmbH

CD314 / KLRK1 antibody

KLRK1 polyclonal antibody ( Cat # PAB6828 ) staining ( 0.3 µg/ml ) of human spleen lysate ( RIPA buffer, 35 µg total protein per lane ) . Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CD314 / KLRK1 antibody

Western Blot: KLRK1 Antibody [NB100-1891] - NB100-1891 staining (0.3ug/ml) of Human Spleen lysate (RIPA buffer, 30ug total protein per lane).Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

CD314 / KLRK1 antibody

Staining of human peripheral blood lymphocytes with MOUSE ANTI HUMAN CD314:Low Endotoxin. Mouse IgG1 1D11 Purified Hu C, F, FN, IP
0.25 mg / €400.00
  Novus Biologicals Inc.

CD314 / KLRK1 antibody

Flow Cytometry: CD314 Antibody (1D11) [NB100-78033] - Human peripheral blood lymphocytes stained with biotinylated 1D11, followed by Sav-PE Mouse IgG1 1D11 Biotin Hu F
0.1 mg / €300.00
  Novus Biologicals Inc.

CD314 / KLRK1 antibody

CD314 / KLRK1 Hamster IgG2 AP-MAB0840 Purified Ms F
0.5 mg / €380.00
  Novus Biologicals Inc.

CD314 / KLRK1 antibody

CD314 / KLRK1 Rat IgG1 CX5 Aff - Purified Ms F
0.1 mg / €390.00
  Novus Biologicals Inc.

CD314 / KLRK1 antibody

CD314 / KLRK1 Rat IgG1 CX5 Aff - Purified Ms F
50 µg / €260.00
  Novus Biologicals Inc.

CD314 / KLRK1 antibody

CD314 / KLRK1 Rat IgG1 CX5 Aff - Purified Ms F
0.1 mg / €380.00
  Novus Biologicals Inc.

CD314 / KLRK1 antibody

CD314 / KLRK1 Rat IgG1 CX5 Aff - Purified Ms F
50 µg / €260.00
  Novus Biologicals Inc.

CD314 / KLRK1 antibody

CD314 / KLRK1 Rat IgG1 CX5 Aff - Purified Ms F, FN
0.1 mg / €340.00
  Novus Biologicals Inc.

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