CD321 / JAM1 antibody

Principal name

CD321 / JAM1 antibody

Alternative names for CD321 / JAM1 antibody

JAM-A, Platelet F11 receptor, F11R, JCAM, PAM1, Junctional adhesion molecule A, Junctional adhesion molecule 1, Platelet adhesion molecule 1

SwissProt ID

O88792 (Mouse), Q2WGK2 (Felca), Q9JHY1 (Rat), Q9XT56 (Bovin), Q9Y624 (Human)

Gene ID

50848 (F11R), 16456

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Por (Porcine)

Available hosts

Mouse, Rat, Rabbit, Goat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Flow Cytometry (F), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN)

Background of CD321 / JAM1 antibody

JAM-A is a surface glycoprotein duplex (32 and 35 kDa) belongingto the immunoglobulin superfamily found on the surface of human platelets and at intercellular junctions of endothelial cells and epithelial cells. JAM-A belongs together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interactions. It co-distributes with other tight junction components such as ZO-1, 7H6 antigen, cingulin and occludin. Moreover, JAM-A plays a role in platelet aggregation, secretion, adhesion, spreading.
In the platelet, JAM-A is a membrane protein involved in 2 distinct processes initiated on the platelet surface. Namely,, antibody-induced platelet aggregation and secretion both dependent on FcgammaRII and GPIIb/IIIa integrin, a process that may be involved in pathophysiological processes associated with certain thrombocytopenias and secondly, antibody mediated platelet adhesion independent from FcgammaRII or fibrinogen receptor that appears to play a role in physiological processes associated with platelet adhesion and aggregation. A physiological role for the JAM-A protein was demonstrated by its phosphorylation after the stimulation of platelets by thrombin and collagen. A pathophysiological role for the JAM-A was revealed by demonstrating the presence of JAM-A antibodies in patients with thrombocytopenia. Adhesion of platelets through JAM-A resulted in events characteristic of the action of cell adhesion molecules. Recent data suggests a role for JAM-A in the adhesion of platelets to cytokine-inflamed endothelial cells and thus in thrombosis and atherosclerosis induced in non-denuded blood vessels by inflammatory processes.

General readings

1. Ueki T, Iwasawa K, Ishikawa H, Sawa Y.
Expression of junctional adhesion molecules on the human lymphatic endothelium. Microvascular research 2008 Mar 75 (2): 269-78. PMID: 17822725

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD321 / JAM1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-F11R mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506017) Mouse IgG2b OTI3H3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD321 / JAM1 antibody

Immunoperoxidase of monoclonal antibody to F11R on formalin-fixed paraffin-embedded human breast cancer tissue. [antibody concentration 1ug/ml] Mouse IgG1 2E3-1C8 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD321 / JAM1 (C-term) antibody

TA305723 (0.3ug/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD321 / JAM1 antibody

Western blot analysis of HeLa cell lysate using F11R antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD321 / JAM1 antibody

Anti-F11R mouse monoclonal antibody (TA506034) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY F11R(RC200004). Mouse IgG1 OTI6E11 Purified Hu ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD321 / JAM1 antibody

CD321 / JAM1 Rat IgG2a BV12 FITC Ms E, F, ICC/IF, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

CD321 / JAM1 antibody

CD321 / JAM1 Rat IgG2a BV12 Purified Ms E, F, ICC/IF
0.1 mg / €450.00
  Acris Antibodies GmbH

CD321 / JAM1 antibody

Immunohistochemical detection of mouse JAM-A on frozen section of mouse fetal liver megakaryocyte(E14.5) with D268-3.This data was provided from Laboratory of Cell Growth and Differentiation, IMCB, The University of Tokyo. Rat IgG2a 27-9 Purified Ms C
0.1 mg / €410.00
  Acris Antibodies GmbH

CD321 / JAM1 (1st extracell. dom.) antibody

CD321 / JAM1 Rabbit IgG Purified Hu F, P, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

CD321 / JAM1 (2nd extracell. dom.) antibody

CD321 / JAM1 Rabbit IgG Purified Hu F, P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

CD321 / JAM1 (Extracell. Dom.) antibody

CD321 / JAM1 Rat IgG2 1M21 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CD321 / JAM1 antibody

CD321 / JAM1 Mouse IgG1 M.Ab.F11 Purified Hu F, IP, WB
0.2 mg / €570.00
  Acris Antibodies GmbH

CD321 / JAM1 antibody

CD321 / JAM1 Mouse IgG1 M.Ab.F11 Purified Hu E, F, FN, ICC/IF, IP, P, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

CD321 / JAM1 antibody

CD321 / JAM1 Mouse IgG1 M.Ab.F11 Purified Hu F, IP, WB
25 µg / €200.00
  Acris Antibodies GmbH

CD321 / JAM1 antibody

CD321 / JAM1 Mouse IgG1 BV16 FITC Hu C, F, ICC/IF, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

CD321 / JAM1 antibody

CD321 / JAM1 Mouse IgG1 BV16 Purified Hu C, F
0.2 mg / €550.00
  Acris Antibodies GmbH

CD321 / JAM1 antibody

CD321 / JAM1 Mouse IgG1 BV16 Purified Hu C, F, ICC/IF, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

CD321 / JAM1 antibody

CD321 / JAM1 Mouse IgG2b BV16 Purified Hu C, F
25 µg / €210.00
  Acris Antibodies GmbH

CD321 / JAM1 antibody

Staining of mouse peripheral blood platelets with RAT ANTI MOUSE CD321: BIOTIN (SM2256B). Rat IgG1 H202-106 Biotin Ms C, F, IP
0.1 mg / €240.00
  Acris Antibodies GmbH

CD321 / JAM1 antibody

Staining of mouse peripheral blood platelets with Rat anti Mouse CD321 antibody (SM2256P/PS/PT). Rat IgG1 H202-106 Purified Ms C, F, IP
0.25 mg / €400.00
  Acris Antibodies GmbH

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