CD324 / Cadherin-1 antibody

Principal name

CD324 / Cadherin-1 antibody

Alternative names for CD324 / Cadherin-1 antibody

Epithelial cadherin, E-cadherin, Uvomorulin, CAM 120/80, CDH1, CDHE, UVO

SwissProt ID

P08641 (Chick), P09803 (Mouse), P12830 (Human), Q6R8F2 (Bovin), Q9R0T4 (Rat)

Gene ID

999 (CDH1), 12550 (Cdh1), 83502

Available reactivities

Hu (Human), Can (Canine), Bov (Bovine), Chk (Chicken), Fe (Feline), GP (Guinea Pig), Gt (Goat), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep), Xen (Xenopus), Mky (Monkey), Snake, Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Rat, Goat

Available applications

Frozen Sections (C), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Luminex (LMNX)

Background of CD324 / Cadherin-1 antibody

Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4), whereas kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins.  
One of the best characterized cadherins is E-cadherin, a 120 kD transmembrane glycoprotein consisting of an 80 kD extracellular and a 40 kD transmembrane and cytoplasmic part. The extracellular domains of E-cadherin are responsible for calcium binding which allows for homophilic interaction with other E-cadherin molecules on the same cell and neighbouring cells. In addition, E-cadherin can interact heterophilically with integrin αEβ7
The cytoplasmic domain of E-cadherin is linked to the actin cytoskeleton through the associated cytoplasmic catenin proteins, thus establishing a complex localized to adherens junctions. In carcinomas E-cadherin is frequently downregulated, which is consistent with its function of an invasion suppressor in normal epithelia.
One of the epithelial cell adhesion molecules, E-Cadherin, plays an important role in the formation of cell-cell contacts in epithelia irrespective their origin form ecto-, meso- or endodermal tissue. This early adhesion event between epithelial cells is a prerequisite for the assembly of all elements of the junctional complex. Furthermore, ECadherin plays a crucial role in the maintenance of the epithelial junctional complex and is as such an important molecule in maintaining epithelial integrity. Over 90% of the malignant tumors are carcinomas. One of the prerequisites for the release of carcinoma cells from the primary site might be a defect in intercellular adhesion mediated by the absence of E-Cadherin expression. Therefore, the expression of E-Cadherin might be an important parameter for the determination of the invasive potential of epithelial neoplasms, and for the transition of a benign to a malignant neoplasm.

General readings

General / background references:Vestweber D & Kemler R Identification of a putative cell adhesion domain of uvomorulin. EMBO J 4:3393-8 (1985). PubMed PMID: 2419126

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD324 / Cadherin-1 antibody

Immunohistochemistry on Paraffin-Embedded Sections of small intestine. Mouse IgG1 5H9 Purified Hu C, ICC/IF, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD324 / Cadherin-1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-CDH1 Mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800076)(1:200) Mouse IgG1 UMAB184 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD324 / Cadherin-1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-CDH1 Mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800076)(1:200) Mouse IgG1 UMAB184 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD324 / Cadherin-1 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800670) Mouse IgG1 OTI3E2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800671) Mouse IgG1 OTI1F3 Purified Can, Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800691) Mouse IgG1 OTI2F9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800692) Mouse IgG1 OTIF1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800696) Mouse IgG1 OTIG1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800718) Mouse IgG1 OTIB11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA803253) Dilution: 1:150 Mouse IgG1 OTI3C11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

Formalin-Fixed, Paraffin-Embedded Human Lung stained with  CD324 / Cadherin-1 Antibody Cat.-No AM20867PU-N (Clone 3F4) at 3 µg/ml after heat-induced antigen retrieval. Mouse IgG1 3F4 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

CD324 / Cadherin-1 (600-707) antibody

Western Blot analysis of MCF7 cell lysate with E-cadherin antibody Rabbit IgG SP64 Purified Hu P, WB
1 ml / €750.00
  Acris Antibodies GmbH

CD324 / Cadherin-1 (600-707) antibody

Western Blot analysis of MCF7 cell lysate with E-cadherin antibody Rabbit IgG SP64 Purified Hu P, WB
0.1 ml / €290.00
  Acris Antibodies GmbH

CD324 / Cadherin-1 antibody

Human breast stained with anti-cadherin-E/E-cadherin antibody Mouse IgG2b SPM471 Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

CD324 / Cadherin-1 antibody

Human breast stained with anti-cadherin-E/E-cadherin antibody Mouse IgG2b SPM471 Purified Hu P
1 ml / €500.00
  Acris Antibodies GmbH

CD324 / Cadherin-1 antibody

Human breast stained with anti-cadherin-E/E-cadherin antibody Mouse IgG2b SPM471 Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

CD324 / Cadherin-1 antibody

AP15381PU Cadherin E antibody staining of Human Skin. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

CD324 / Cadherin-1 antibody

AP15381PU Cadherin E antibody staining of Human Skin. Rabbit Purified Hu P
1 ml / €440.00
  Acris Antibodies GmbH

CD324 / Cadherin-1 antibody

AP15381PU Cadherin E antibody staining of Human Skin. Rabbit Purified Hu P
0.1 ml / €180.00
  Acris Antibodies GmbH

CD324 / Cadherin-1 (N-term) antibody

Western blot analysis of CDH1 Antibody (N-term) (Cat.#TA302227) in 293 cell line lysates (35ug/lane). CDH1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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