CD324 / Cadherin-1 antibody

Principal name

CD324 / Cadherin-1 antibody

Alternative names for CD324 / Cadherin-1 antibody

Epithelial cadherin, E-cadherin, Uvomorulin, CAM 120/80, CDH1, CDHE, UVO

SwissProt ID

P08641 (Chick), P09803 (Mouse), P12830 (Human), Q6R8F2 (Bovin), Q9R0T4 (Rat)

Gene ID

999 (CDH1), 12550 (Cdh1), 83502

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Por (Porcine), Mky (Monkey), Chk (Chicken), Rb (Rabbit), Snake, Can (Canine), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunoprecipitation (IP), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Luminex (LMNX)

Background of CD324 / Cadherin-1 antibody

Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4), whereas kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins.  
One of the best characterized cadherins is E-cadherin, a 120 kD transmembrane glycoprotein consisting of an 80 kD extracellular and a 40 kD transmembrane and cytoplasmic part. The extracellular domains of E-cadherin are responsible for calcium binding which allows for homophilic interaction with other E-cadherin molecules on the same cell and neighbouring cells. In addition, E-cadherin can interact heterophilically with integrin αEβ7
The cytoplasmic domain of E-cadherin is linked to the actin cytoskeleton through the associated cytoplasmic catenin proteins, thus establishing a complex localized to adherens junctions. In carcinomas E-cadherin is frequently downregulated, which is consistent with its function of an invasion suppressor in normal epithelia.
One of the epithelial cell adhesion molecules, E-Cadherin, plays an important role in the formation of cell-cell contacts in epithelia irrespective their origin form ecto-, meso- or endodermal tissue. This early adhesion event between epithelial cells is a prerequisite for the assembly of all elements of the junctional complex. Furthermore, ECadherin plays a crucial role in the maintenance of the epithelial junctional complex and is as such an important molecule in maintaining epithelial integrity. Over 90% of the malignant tumors are carcinomas. One of the prerequisites for the release of carcinoma cells from the primary site might be a defect in intercellular adhesion mediated by the absence of E-Cadherin expression. Therefore, the expression of E-Cadherin might be an important parameter for the determination of the invasive potential of epithelial neoplasms, and for the transition of a benign to a malignant neoplasm.

General readings

Fulga V., et al. (2015) Anticancer Res. 35:759-765.Zhang L., el al. (2014) Mutat. Res. 770:106-111.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD324 / Cadherin-1 antibody

Immunohistochemistry on Paraffin-Embedded Sections of small intestine. Mouse IgG1 5H9 Purified Hu C, ICC/IF, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CD324 / Cadherin-1 antibody

  CDH1 mouse monoclonal antibody,clone UMAB184  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-CDH1 Mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800076)(1:200) Mouse IgG1 UMAB184 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD324 / Cadherin-1 antibody

  CDH1 mouse monoclonal antibody,clone UMAB184  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-CDH1 Mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800076)(1:200) Mouse IgG1 UMAB184 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD324 / Cadherin-1 antibody

  Mouse Monoclonal anti-Cadherin-E/E-Cadherin Antibody  
Human Breast stained with anti-Cadherin-E_E-Cadherin antibody. Mouse IgG2 SPM471 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD324 / Cadherin-1 antibody

  Rabbit Monoclonal anti-Cadherin-E/E-Cadherin Antibody  
Western Blot analysis of MCF7 cell lysate with E-cadherin antibody Rabbit IgG SP64 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD324 / Cadherin-1 antibody

  CDH1 (E Cadherin) mouse monoclonal antibody, clone OTI3E2 (formerly 3E2)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800670) Mouse IgG1 OTI3E2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

  CDH1 (E Cadherin) mouse monoclonal antibody, clone OTI1F3 (formerly 1F3)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800671) Mouse IgG1 OTI1F3 Purified Can, Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

  CDH1 (E Cadherin) mouse monoclonal antibody, clone OTI2F9 (formerly 2F9)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800691) Mouse IgG1 OTI2F9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

  CDH1 (E Cadherin) mouse monoclonal antibody, Clone , clone OTIF1 (formerly F1)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800692) Mouse IgG1 OTIF1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

  CDH1 (E Cadherin) mouse monoclonal antibody, Clone , clone OTIG1 (formerly G1)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800696) Mouse IgG1 OTIG1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

  CDH1 (E Cadherin) mouse monoclonal antibody, Clone , clone OTIB11 (formerly B11)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800718) Mouse IgG1 OTIB11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

  CDH1 mouse monoclonal antibody, clone OTI3C11 (formerly 3C11)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CDH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA803253) Dilution: 1:150 Mouse IgG1 OTI3C11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD324 / Cadherin-1 antibody

Formalin-Fixed, Paraffin-Embedded Human Lung stained with  CD324 / Cadherin-1 Antibody Cat.-No AM20867PU-N (Clone 3F4) at 3 µg/ml after heat-induced antigen retrieval. Mouse IgG1 3F4 Purified Hu E, P, PLA, WB
50 µg / €530.00
  Acris Antibodies GmbH

CD324 / Cadherin-1 (N-term) antibody

  Rabbit Polyclonal Antibody against CDH1 (N-term)  
Western blot analysis of CDH1 Antibody (N-term) (Cat.#TA302227) in 293 cell line lysates (35ug/lane). CDH1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD324 / Cadherin-1 (C-term) antibody

  Rabbit Polyclonal Antibody against CDH1 (C-term)  
Western blot analysis of CDH1 Antibody (C-term) (Cat.#TA302228) in A375 cell line lysates (35ug/lane). CDH1 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD324 / Cadherin-1 antibody

  Anti-CDH1 Rabbit Polyclonal Antibody  
Predicted band size: 114 kDa . Positive control: Human brain malignant glioma tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/1750 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD324 / Cadherin-1 antibody

  Anti-pan CDH Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human breast and lung cancer. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using pan CDH antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD324 / Cadherin-1 antibody

  Anti-pan CDH Rabbit Polyclonal Antibody  
Predicted cell location: Cell membrane,Cytoplasm. Positive control: Human cervical and lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human cervical cancer tissue using pan CDH antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD324 / Cadherin-1 antibody

  Mouse monoclonal CDH1 Antibody(Ascites)  
CDH1 Antibody(Cat. #TA325007) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the CDH1 antibody detected the CDH1 protein (arrow). Mouse IgG1 813CT11.1.3 Ascites Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD324 / Cadherin-1 antibody

  Mouse monoclonal CDH1 Antibody  
CDH1 Antibody (Cat. #TA325140) western blot analysis in WiDr cell line and mouse stomach tissue lysates (35ug/lane).This demonstrates the CDH1 antibody detected the CDH1 protein (arrow). Mouse IgG1 813CT11.1.3 Purified Hu, Ms WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

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