CD327 / SIGLEC6 antibody

Principal name

CD327 / SIGLEC6 antibody

Alternative names for CD327 / SIGLEC6 antibody

Siglec-6, Obesity-binding protein 1, CDw327, CD33L, CD33L1, OBBP1, OB-BP1, Sialic acid-binding Ig-like lectin 6, CD33 antigen-like 1

SwissProt ID

O43699 (Human), O43699-4

Gene ID

946 (SIGLEC6)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), EPair for Elisa (EPair), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Enzyme Immunoassay (E)

Background of CD327 / SIGLEC6 antibody

SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.

General readings

1. Winn VD, Gormley M, Paquet AC, Kjaer-Sorensen K, Kramer A, Rumer KK, Haimov-Kochman R, Yeh RF, Overgaard MT, Varki A, Oxvig C, Fisher SJ,
Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2.
Endocrinology 2009 Jan 150 (1): 452-62.
PMID: 18818296

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD327 / SIGLEC6 antibody

  Goat Anti-SIGLEC6 Antibody  
(0.5ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD327 / SIGLEC6 antibody

  Rabbit Polyclonal Anti-SIGLEC6 Antibody  
WB Suggested Anti-SIGLEC6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Eq, Hu, Por WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD327 / SIGLEC6 antibody

  Rabbit Polyclonal Anti-SIGLEC6 Antibody  
WB Suggested Anti-SIGLEC6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD327 / SIGLEC6 antibody

  Rabbit Polyclonal Anti-SIGLEC6 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Human placenta tissue, Primary antibody: (SIGLEC6 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD327 / SIGLEC6 (N-term) antibody

Western blot analysis of SIGLEC6 Antibody (N-term) (AP11628PU-N) in NCI-H460 cell line lysates (35 µg/lane). SIGLEC6 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

CD327 / SIGLEC6 (C-term) antibody

Formalin-fixed and paraffin-embedded human breast carcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

SIGLEC6 overexpression lysate

SIGLEC6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SIGLEC6 overexpression lysate

SIGLEC6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SIGLEC6 overexpression lysate

SIGLEC6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SIGLEC6 overexpression lysate

SIGLEC6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

SIGLEC6 overexpression lysate

SIGLEC6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SIGLEC6 (mGFP-tagged) - Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGLEC6 (mGFP-tagged) - Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGLEC6 (mGFP-tagged) - Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGLEC6 (mGFP-tagged) - Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGLEC6 (mGFP-tagged)-Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGLEC6 (mGFP-tagged)-Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €990.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGLEC6 (mGFP-tagged)-Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGLEC6 (mGFP-tagged)-Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €970.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGLEC6 (mGFP-tagged)-Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 6, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGLEC6 (mGFP-tagged)-Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 6, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGLEC6 (Myc-DDK tagged) - Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGLEC6 (Myc-DDK tagged) - Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGLEC6 (Myc-DDK tagged) - Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGLEC6 (Myc-DDK tagged) - Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGLEC6 (Myc-DDK-tagged)-Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGLEC6 (Myc-DDK-tagged)-Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, SIGLEC6 (Myc-DDK-tagged)-Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, SIGLEC6 (Myc-DDK-tagged)-Human sialic acid binding Ig-like lectin 6 (SIGLEC6), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €870.00
  OriGene Technologies, Inc.

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