CD327 / SIGLEC6 antibody

Principal name

CD327 / SIGLEC6 antibody

Alternative names for CD327 / SIGLEC6 antibody

Siglec-6, Obesity-binding protein 1, CDw327, CD33L, CD33L1, OBBP1, OB-BP1, Sialic acid-binding Ig-like lectin 6, CD33 antigen-like 1

SwissProt ID

O43699 (Human), O43699-4

Gene ID

946 (SIGLEC6)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), EPair for Elisa (EPair), Immunoprecipitation (IP)

Background of CD327 / SIGLEC6 antibody

SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.

General readings

1. Winn VD, Gormley M, Paquet AC, Kjaer-Sorensen K, Kramer A, Rumer KK, Haimov-Kochman R, Yeh RF, Overgaard MT, Varki A, Oxvig C, Fisher SJ,
Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2.
Endocrinology 2009 Jan 150 (1): 452-62.
PMID: 18818296

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD327 / SIGLEC6 antibody

(0.5ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD327 / SIGLEC6 (N-term) antibody

Western blot analysis of SIGLEC6 Antibody (N-term) (AP11628PU-N) in NCI-H460 cell line lysates (35 µg/lane). SIGLEC6 (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

CD327 / SIGLEC6 (C-term) antibody

Formalin-fixed and paraffin-embedded human breast carcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD327 / SIGLEC6 antibody

Western Blot analysis of SIGLEC6 expression in transfected 293T cell line (H00000946-T01) by SIGLEC6 MaxPab polyclonal antibody.

Lane 1: SIGLEC6 transfected lysate(48.07 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

CD327 / SIGLEC6 antibody

CD327 / SIGLEC6 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CD327 / SIGLEC6 antibody

SIGLEC6 MaxPab rabbit polyclonal antibody. Western Blot analysis of SIGLEC6 expression in A-431. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

CD327 / SIGLEC6 antibody

Western Blot analysis of SIGLEC6 expression in transfected 293T cell line (H00000946-T01) by SIGLEC6 MaxPab polyclonal antibody.

Lane 1: SIGLEC6 transfected lysate(48.30 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CD327 / SIGLEC6 antibody

Western Blot analysis of SIGLEC6 expression in transfected 293T cell line by SIGLEC6 monoclonal antibody (M02), clone 2G6.

Lane 1: SIGLEC6 transfected lysate(48.3 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2b 2G6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD327 / SIGLEC6 antibody

CD327 / SIGLEC6 Rabbit Hu E
0.4 ml / €390.00
  Abnova Taiwan Corp.

CD327 / SIGLEC6 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with SIGLEC6 polyclonal antibody ( Cat # PAB3637 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

CD327 / SIGLEC6 antibody

Human HepG2; WB Suggested Anti-SIGLEC6 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: HepG2 cell lysate; SIGLEC6 antibody - N-terminal region (ARP41924_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

CD327 / SIGLEC6 antibody

Hum. Fetal Muscle; Host:Rabbit. Target Name:SIGLEC6. Sample Tissue:Human Fetal Muscle. Antibody Dilution: 1.0ug/ml.; SIGLEC6 antibody - N-terminal region (ARP41925_P050) in Hum. Fetal Muscle cells using Western Blot Rabbit Aff - Purified Bov, Hu WB
50 µg / €350.00
  AVIVA Systems Biology

CD327 / SIGLEC6 antibody

Human HepG2; WB Suggested Anti-SIGLEC6 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: HepG2 cell lysate; SIGLEC6 antibody - C-terminal region (ARP41926_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

CD327 / SIGLEC6 antibody

Human Lung; WB Suggested Anti-SIGLEC6 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Human Lung; SIGLEC6 antibody - middle region (ARP42739_P050) in Human Lung cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

CD327 / SIGLEC6 antibody

CD327 / SIGLEC6 Goat Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

CD327 / SIGLEC6 antibody

Immunohistochemistry-Paraffin: SIGLEC6 Antibody [NBP1-85756] - Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

CD327 / SIGLEC6 antibody

Immunohistochemistry-Paraffin: SIGLEC6 Antibody [NBP1-85757] - Immunohistochemical staining of human placenta shows strong membrane and cytoplasmic positivity in trophoblastic cell. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD327 / SIGLEC6

CD327 / SIGLEC6 Human
10 µg / €540.00
  Abnova Taiwan Corp.

CD327 / SIGLEC6

CD327 / SIGLEC6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CD327 / SIGLEC6

CD327 / SIGLEC6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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