CD328 / SIGLEC7 antibody

Principal name

CD328 / SIGLEC7 antibody

Alternative names for CD328 / SIGLEC7 antibody

Siglec-7, QA79 membrane protein, p75, D-siglec, CDw328, AIRM1, Sialic acid-binding Ig-like lectin 7, Adhesion inhibitory receptor molecule 1

SwissProt ID

Q9Y286 (Human)

Gene ID

27036 (SIGLEC7)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Flow Cytometry (F), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD328 / SIGLEC7 antibody

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIM). SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. Sequence analysis predicted that the 697-amino acid SIGLEC10 protein contains a signal peptide, an N-terminal V-set Ig-like domain and four C2-set Ig-like domains, five potential N-linked glycosylation sites, a transmembrane region, and a 126-residue cytoplasmic tail with 3 putative ITIMs. Northern blot analysis detected a major 3.0-kb SIGLEC10 transcript, with highest levels in spleen, lymph node, blood leukocytes, and appendix. Little or no expression was observed in pancreas, thyroid, and testis. Flow cytometric analysis demonstrated eosinophil-specific expression of SIGLEC10, but at a lower level than that of SIGLEC8. Expression was also detected on monocytes and a CD16-positive/CD56-negative natural killer-like lymphocyte population. After sialidase treatment, which is necessary for unmasking the sialic acid-binding site on SIGLECs interacting with cell surface sialic acids, cells expressing SIGLEC10 bound to red blood cells. Immunoprecipitation analysis indicated expression of a 100- to 120-kD monomeric protein, higher than the predicted molecular mass, suggesting that SIGLEC10 is glycosylated.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD328 / SIGLEC7 antibody

WB Suggested Anti-SIGLEC7 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD328 / SIGLEC7 antibody

WB Suggested Anti-SIGLEC7 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: 721_B cell lysate.SIGLEC7 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells Rabbit IgG Purified Bov, Can, Eq, GP, Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD328 / SIGLEC7 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIGLEC7 (RC213691, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SIGLEC7. Mouse IgG1 OTI1A1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD328 / SIGLEC7 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIGLEC7 (RC213691, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SIGLEC7. Mouse IgG1 OTI1A11 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD328 / SIGLEC7 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIGLEC7 (RC213691, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SIGLEC7. Mouse IgG2b OTI1A12 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD328 / SIGLEC7 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIGLEC7 (RC213691, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SIGLEC7. Mouse IgG1 OTI1D11 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD328 / SIGLEC7 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIGLEC7 (RC213691, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SIGLEC7. Mouse IgG1 OTI1E3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD328 / SIGLEC7 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIGLEC7 (RC213691, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SIGLEC7. Mouse IgG2b OTI1G7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD328 / SIGLEC7 antibody

CD328 / SIGLEC7 Mouse IgG1 5-386 FITC Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD328 / SIGLEC7 antibody

CD328 / SIGLEC7 Mouse IgG1 5-386 Purified Hu C, F
0.2 mg / €490.00
  Acris Antibodies GmbH

CD328 / SIGLEC7 antibody

CD328 / SIGLEC7 Mouse IgG1 5-386 Purified Hu C, F
0.1 mg / €290.00
  Acris Antibodies GmbH

CD328 / SIGLEC7 antibody

CD328 / SIGLEC7 Mouse IgG1 5-386 PE Hu F
100 Tests / €470.00
  Acris Antibodies GmbH

CD328 / SIGLEC7 antibody

CD328 / SIGLEC7 Mouse IgG1 6-434 Purified Hu F
0.1 mg / €210.00
  Acris Antibodies GmbH

CD328 / SIGLEC7 antibody

CD328 / SIGLEC7 Mouse IgG1 6-434 PE Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD328 / SIGLEC7 antibody

Formalin-fixed and paraffin-embedded hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD328 / SIGLEC7 antibody

Formalin-fixed and paraffin-embedded human breast carcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD328 / SIGLEC7 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD328 / SIGLEC7 antibody

CD328 / SIGLEC7 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CD328 / SIGLEC7 antibody

CD328 / SIGLEC7 Mouse IgG2a 3H1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD328 / SIGLEC7 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with SIGLEC7 polyclonal antibody ( Cat # PAB3638 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

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