CD333 / FGFR3 antibody

Principal name

CD333 / FGFR3 antibody

Alternative names for CD333 / FGFR3 antibody

FGFR-3, JTK4, Fibroblast growth factor receptor 3

SwissProt ID

P18460 (Chick), P22607 (Human), Q61851 (Mouse)

Gene ID

2261 (FGFR3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Neutralisation (NEUT)

Background of CD333 / FGFR3 antibody

Fibroblast growth factors (FGFs) are members of a large family of structurally related polypeptides (MW 17-38 kD) that are potent physiological regulators of growth and differentiation for a wide variety of cells of mesodermal, ectodermal and endodermal origin. FGFs are substantially involved in normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, and in hematopoiesis as well as in tissue remodelling and maintenance. They have also been implicated in pathological conditions such as tumorigenesis and metastasis. The FGF family consists of at least seventeen members designated FGF1 through FGF17. To date, four genes encoding for high affinity cell surface FGF receptors (FGFRs) have been identified: FGFR1 [flg-1(fms-like gene 1)]; FGFR2 [bek (bacterial expressed kinase gene product)]; FGFR3 (cek-2) and by alternative splicing have been reported. Soluble, secreted or possibly cleaved forms of FGFR-1 and FGFR-2 have also been found in body fluids or were artificially constructed. An example is a soluble FGF-binding protein containing the extracellular region of FGFR3 and the secreted form of placental alkaline phosphatase (FRAP3). FGFRs are members of the tyrosine kinase family of growth factor receptors. They are glycosylated 110-150 kD proteins consiting of an extracellular domain, a single transmembrane region and a cytoplasmic split tyrosine kinase domain, which is activated following ligand binding and receptor dimerization. The extracellular, ligand binding, region is constructed with either two (beta type) or typically three (alpha-type) immunoglobulin (Ig)-like domains, and an eight amino acid "acidic box". The ligand binding site of all FGFRs is confined to the extracellular Ig-like domains 2 and 3. FGFRs exhibit overlapping recognition and redundant specificity. One receptor type may bind several of the FGFs with a similar affinity. Also, one FGF type may bind similarly to several distinct receptors. This accounts for the rather identical effects of different FGF ligands on common cell types. FGFs binding to cellular FGFRs depend on, or is markedly facilitated by the low-affinity interaction of FGFs with the polysaccharide component of cell surface or extracellular matrix heparan sulfate proteoglycans (HSPG). Signal transduction by FGFRs requires dimerization or oligomerization and autophosphorylation of the receptors through their tyrosine kinase domain. Subsequent association with cytoplasmic signalling molecules leads to DNA synthesis or differentiation. The signalling and biological responses elicited by distinct FGFRs substantially differ and are dictated by the intracellular domain. FGFR3 is widely expressed in many fetal and adult human and animal tissues. The FGFR3 expression profile largely correlates with its tissue specific expression at the mRNA level.

General readings

General / background references:Baird A Fibroblast growth factors: activities and significance of non-neurotrophin neurotrophic growth factors. Curr Opin Neurobiol 4:78-86 (1994). PubMed PMID: 8173328
Givol D & Yayon A Complexity of FGF receptors: genetic basis for structural diversity and functional specificity. FASEB J 6:3362-9 (1992). PubMed PMID: 1464370
Burgess WH & Maciag T The heparin-binding (fibroblast) growth factor family of proteins. Annu Rev Biochem 58:575-606 (1989). PubMed PMID: 2549857
Klagsbrun M The fibroblast growth factor family: structural and biological properties. Prog Growth Factor Res 1:207-35 (1989). PubMed PMID: 2491263

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD333 / FGFR3 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-FGFR3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801078) Mouse IgG1 OTI1B10 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD333 / FGFR3 (359-372) antibody

AP15553PU FGFR3 antibody staining of Human Breast. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

CD333 / FGFR3 (359-372) antibody

AP15553PU FGFR3 antibody staining of Human Breast. Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

CD333 / FGFR3 (359-372) antibody

AP15553PU FGFR3 antibody staining of Human Breast. Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

CD333 / FGFR3 antibody

Western blot analysis of extracts from LOVO cells, using FGFR3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD333 / FGFR3 antibody

Western blot analysis of FGFR3 in SK-N-SH cell lysate with FGFR3 antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD333 / FGFR3 antibody

Predicted cell location: Cytoplasm, Cell membrane . Positive control: Human cervical cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using FGFR3 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD333 / FGFR3 antibody

Predicted cell location: Cytoplasm. Positive control: Human liver cancer and tonsil tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer and tonsil tissue using FGFR3 antibody at dilution 1/5, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD333 / FGFR3 antibody

Western blot analysis on LOVO cell lysate using FGFR3 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD333 / FGFR3 antibody

ELISA: FGFR3 Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

CD333 / FGFR3 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FGFR3 (RC215533, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FGFR3. Mouse IgG2a OTI1G10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD333 / FGFR3 antibody

Immunohistochemistry (IHC) analyzes of FGFR3 antibody (Cat.-No.: AP06120PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD333 / FGFR3 (359-372) antibody

Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu P
50 µg / €470.00
  Acris Antibodies GmbH

CD333 / FGFR3 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD333 / FGFR3 antibody

CD333 / FGFR3 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

CD333 / FGFR3 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with FGFR3 polyclonal antibody ( Cat # PAB3043 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

CD333 / FGFR3 antibody

Immunohistochemical staining of FGFR3 on formalin fixed, paraffin embedded breast cancer with FGFR3 polyclonal antibody. Rabbit Hu P
0.1 ml / €390.00
  Abnova Taiwan Corp.

CD333 / FGFR3 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using FGFR3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

CD333 / FGFR3 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using FGFR3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

CD333 / FGFR3 antibody

CD333 / FGFR3 Rabbit IgG Aff - Purified Hu, Rt ICC/IF, P, WB
0.1 mg / €290.00
  Boster Immunoleader

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