CD339 / JAG1 antibody

Principal name

CD339 / JAG1 antibody

Alternative names for CD339 / JAG1 antibody

Jagged-1, hJ1, JAGL1

SwissProt ID

P78504 (Human), Q63722 (Rat), Q9QXX0 (Mouse)

Gene ID

182 (JAG1), 831828 (ATB' ALPHA), 16449 (Jag1)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Chimp (Chimpanzee), Bov (Bovine), Can (Canine), Por (Porcine)

Available hosts

Goat, Mouse, Rabbit, Hamster

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), ELISA (detection) (E(detection)), Neutralisation (NEUT)

Background of CD339 / JAG1 antibody

Jagged 1 is a notch ligand. The Notch signaling system regulates proliferation, differentiation and apoptosis in many tissues, including hematopoietic tissue. Notch is a family of transmembrane receptors activated by ligands such as jagged 1, jagged 2 and delta 1 that are expressed on adjacent cells. Hematopoietic stem cells and early progenitors express notch 1 and notch 2, whereas primary stromal cultures have been shown to express jagged 1, indicating that jagged 1 may play a role in nurturing progenitor cells within the hematopoietic microenvironment. Cells engineered to express high levels of jagged 1 caused a four-fold increase in formation of hematopoietic progenitor cell colonies. However, without the presence of other cytokines that stimulate proliferation and maturation, such as IL3, IL6, SCF and GCSF, jagged 1 actually decreased myeloid colony formation by CD34+ cells, suggesting that jagged 1 modulates cytokine signals and helps preserve CD34+ cells in an immature state.

General readings

Proweller A et al. Notch signaling represses myocardin-induced smooth muscle cell differentiation. J Biol Chem : (2005). PubMed PMID: 15634680
Mancini SJ et al. Jagged1 dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood : (2004). PubMed PMID: 15550486
Stidworthy MF et al. Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination. Brain 127:1928-41 (2004). PubMed PMID: 15289265
Kostyszyn B et al. Distribution of presenilin 1 and 2 and their relation to Notch receptors and ligands in human embryonic/foetal central nervous system. Brain Res Dev Brain Res 151:75-86 (2004). PubMed PMID: 15246694

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD339 / JAG1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-JAG1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807944)(1:150) Mouse IgG2a OTI3A10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD339 / JAG1 antibody

Western blot analysis of Jagged 1 using 3T3 cell lysate. Rabbit Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD339 / JAG1 (110-125) antibody

WB using anti-Jagged-1 antibody shows detection of Jagged-1 protein in various whole cell lysates: human brain (lane 1), human kidney (lane 2), human liver (lane 3), and mouse liver (lane 5).  Lane 4 contained sample buffer only.Each lane contains approximately 20 µg of lysate.  Primary antibody was used at a 1:500 dilution. Predicted molecular weight is 134 kDa. Rabbit IgG Aff - Purified Chimp, Hu, Ms, Rt E, ICC/IF, P, WB
0.5 mg / €325.00
  OriGene Technologies, Inc.

CD339 / JAG1 (C-term) antibody

TA326300 (2µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt P
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD339 / JAG1 antibody

Western blot analysis of JAG1 in HeLa cell lysate with JAG1 antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD339 / JAG1 (110-125) antibody

AP08812PU-N at 5 µg/ml, staining JAG1 in Formalin-Fixed, Paraffin-Embedded Human Kidney tissue by Immunohistochemistry. Rabbit IgG Aff - Purified Chimp, Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD339 / JAG1 (C-term) antibody

Western blot analysis of CD339 / JAG1 Antibody (C-term) Cat.-No AP52261PU-N in K562 cell line lysates (35ug/lane). Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD339 / JAG1 antibody

CD339 / JAG1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CD339 / JAG1 antibody

Western Blot analysis of JAG1 expression in transfected 293T cell line (H00000182-T01) by JAG1 MaxPab polyclonal antibody.

Lane 1: JAG1 transfected lysate(133.98 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CD339 / JAG1 antibody

CD339 / JAG1 Mouse IgG1 1E12 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

CD339 / JAG1 antibody

CD339 / JAG1 Mouse IgG2b 1B7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD339 / JAG1 antibody

CD339 / JAG1 Mouse IgG2b 3C10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD339 / JAG1 antibody

Immunohistochemical staining of human cervical cancer tissue ( 40X magnification ) using JAG1 polyclonal antibody ( Cat # PAB9954 ) . Tissue was fixed with formalin and embedded in paraffin.
Hematoxylin was used to counter-stain cells. A 1 : 100 dilution of primary antibody was used.
Personal Communication. Martin Kast Laboratory. Hu
0.1 mg / €390.00
  Abnova Taiwan Corp.

CD339 / JAG1 antibody

Jagged1 staining of paraffin-embedded human kidney cancer. HRP-DAB reagents (brown color) were used for the detection and counterstained using hematoxylin (blue). Goat Aff - Purified Hu C, E, F, ICC/IF, IP, P, WB
0.1 mg / €450.00
  Neuromics Antibodies

CD339 / JAG1 antibody

Immunofluorescence: Jagged1 Antibody [NB600-1161] - of  human corneal epithelial cells. Primary  antibody was used at a 1:500 dilution.  The Jagged1 (green staining) is localized  to the cytoplasm and is consistent  with reports in the literature. The  nucleus is stained with Bis benzimide  (blue). Rabbit IgG Purified Hu, Ms E, ICC/IF, P, WB
0.5 mg / €510.00
  Novus Biologicals Inc.

CD339 / JAG1 antibody

Immunohistochemistry-Paraffin: Jagged1 Antibody [NBP1-90208] Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in renal tubules with a granular pattern. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

CD339 / JAG1 antibody

Immunohistochemistry-Paraffin: Jagged1 Antibody (EPR4290) [NBP1-95754] - Jagged 1. Rabbit EPR4290 Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD339 / JAG1

CD339 / JAG1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CD339 / JAG1

CD339 / JAG1 Human
10 µg / €540.00
  Abnova Taiwan Corp.

CD339 / JAG1

CD339 / JAG1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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