CD340 / ERBB2 / HER2 antibody

Principal name

CD340 / ERBB2 / HER2 antibody

Alternative names for CD340 / ERBB2 / HER2 antibody

HER-2, NEU, p185erbB2, NGL, c-erbB-2, MNL19, Receptor tyrosine-protein kinase erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2

SwissProt ID

O18735 (Canfa), P04626 (Human), P06494 (Rat), P70424 (Mouse)

Gene ID

2064 (ERBB2), 13866 (Erbb2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Hst (Hamster), Bt (Bat), Bov (Bovine), Eq (Equine), Mky (Monkey), Prim (Primate), Por (Porcine)

Available hosts

Rabbit, Mouse, Rat, Chicken, Sheep, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Radioimmunoassay (R), Flow Cytometry (F), Immunoelectron Microscopy (EM), Dot blot (Dot), Luminex (LMNX)

Background of CD340 / ERBB2 / HER2 antibody

The tyrosine kinase receptor erbB2, also known in humans as Her2, is a member of the epidermal growth factor receptor (EGFR or erbB1) family, which also includes erbB3 and erbB4 that are gene products of proto-oncogenes. Protocogenes play an important role in normal proliferation of cells. The interaction of proto-oncogenes with other tumor suppressor proteins (P53, P14ARF etc.) determine the normal or abnormal course of cell cycle and cell division leading to uncontrolled cell proliferation (1). Her 2 is found on chromosome 17 and codes for a protein that serves as a cell surface receptor. Her protein family of receptor has 4 structurally similar members of membrane receptors that have intrinsic tyrosine kinase activity. These Her receptors working in concert, determine the regulation of cell growth and differentiation in a complex manner. Her-2 receptor is still considered to be an orphan receptor with no identifiable ligand. Her family receptors can form homo or hetero dimers with other compounds. The activation of these homo-heterodimmeric complexes by ligand binding led to an activation of intrinsic tyrosine kinase activity that triggers a cascade of signal transduction activity in cell. Some of these signals are transduced across the cell membranes in to cytoplasm and triggers the gene activation. A better understanding of these receptors and identification of their respective ligands will greatly enhance our understanding of cell cycle and uncontrolled cell division as seen in cancerous tissues. Several steps in these pathways are currently being targeted for therapeutic intervention, including tyrosine kinase inhibitors. There are at least 2 humanized recombinant monoclonal antibodies (Trastuzumab and pertuzumab) that target extra cellular regions of the Her 2 tyrosine kinase receptor and have been used in human trials for the treatment of breast cancer (2).
Herceptin-2 is a 1342 amino acid protein (approximate MW 170-172 kDa) when analyzed on reduced SDS-PAGE gels. Her2 is over expressed in cells of many cancer types. It’s over expression is nicely correlated with a poor prognosis of breast and ovarian cancer in patients. ErbB receptors bind to a family of growth factors, termed neuregulins/heregulin (NRG/HRG), which comprise NRG-1, -2, -3, and -4 and include multiple variants. ErbB2/Her2 is an orphan receptor that does not bind ligand alone but heterodimerizes with the other erbB receptors for NRG signaling. Her 2 is a receptor tyrosine kinase with intrinsic tyrosine kinase domain.

General readings

1. Azios NG, Romero FJ, Denton MC, Doherty JK, Clinton GM. Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF
activation of the EGF receptor.
2. Jhabvala-Romero F, Evans A, Guo S, Denton M, Clinton GM. Herstatin inhibits heregulinmediated breast cancer cell growth and overcomes tamoxifen resistance in breast cancer cells that overexpress HER-2.
3. Doherty JK, Bond C, Jardim A, Adelman JP, Clinton GM. The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-ERBB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503443) Mouse IgG2a OTI4F10 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD340 / ERBB2 / HER2 pTyr1248 antibody

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using CD340 / ERBB2 / HER2 Antibody (pTyr1248) Cat.-No AP02377PU Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

CD340 / ERBB2 / HER2 pTyr1248 antibody

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using CD340 / ERBB2 / HER2 Antibody (pTyr1248) Cat.-No AP02377PU Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of bladder tissue using anti-ERBB2mouse monoclonal antibody. (Clone UMAB33, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB33 Purified Can, Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD340 / ERBB2 / HER2 antibody

CD340 / ERBB2 / HER2 Mouse IgG2b UMAB34 Purified Can, Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of bladder tissue using anti-ERBB2mouse monoclonal antibody. (Clone UMAB35, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2b UMAB35 Purified Can, Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of bladder tissue using anti-ERBB2mouse monoclonal antibody. (Clone UMAB36, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB36 Purified Hu, Mky, Ms, Rt P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of bladder tissue using anti-ERBB2mouse monoclonal antibody. (Clone UMAB33, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2a UMAB33 Purified Can, Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD340 / ERBB2 / HER2 antibody

CD340 / ERBB2 / HER2 Mouse IgG2b UMAB34 Purified Can, Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of bladder tissue using anti-ERBB2mouse monoclonal antibody. (Clone UMAB35, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2b UMAB35 Purified Can, Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of bladder tissue using anti-ERBB2mouse monoclonal antibody. (Clone UMAB36, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB36 Purified Hu, Mky, Ms, Rt P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-ERBB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503503) Mouse IgG2b OTI1D9 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-ERBB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA503504) Mouse IgG1 OTI4G10 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-ERBB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503523) Mouse IgG2a OTI1C5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-ERBB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503524) Mouse IgG2a OTI11A7 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-ERBB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503525) Mouse IgG2b OTI3F11 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-ERBB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503526) Mouse IgG2b OTI9G2 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-ERBB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503527) Mouse IgG2a OTI12G4 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-ERBB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505802) Mouse IgG2a OTI6F3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD340 / ERBB2 / HER2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-ERBB2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505803) Mouse IgG1 OTI5C3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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