CD38 antibody

Principal name

CD38 antibody

Alternative names for CD38 antibody

cADPr hydrolase 1, T10, ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1

SwissProt ID

P28907 (Human), P56528 (Mouse), Q64244 (Rat)

Gene ID

12494 (Cd38), 952 (CD38), 25668

Available reactivities

Ms (Mouse), Hu (Human), Mky (Monkey), Rt (Rat)

Available hosts

Rat, Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Flow Cytometry (F), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Enzyme Immunoassay (E), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD38 antibody

CD38 (T10) is a single chain 42 to 46 kDa type II integral transmembrane glycoprotein with a short N terminal cytoplasmic tail. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages and may be detected on cells from multiple myeloma, ALL (B and T) and some AML. It is expressed by murine, but not human, hematopoietic progenitors. In normal lymph nodes and tonsils the antigen is detected mainly on B cells in germinal centers and in plasma cells. The extracellular domain of the molecule shares a high homology sequence with Aplysia ADP ribosyl cyclase. CD38 functions as a multicatalytic ectoenzyme serving as ADP ribosyl cyclase, ADPR hydrolase and possibly NAD+ glycohydrolase, or as a surface receptor. In mice, CD38 is expressed by follicular B cells, is down regulated on germinal centre B cells, and is not expressed by mature plasma cells. Murine CD38 is also expressed by all Mac1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone marrow derived macrophages. This pattern of expression contrasts strikingly with that seen in the human. Monoclonal antibodies to CD38 have been shown to be useful in subtyping of lymphomas and leukemias, inhibition of B lymphopoiesis, detection of plasma cells, protection of B cells from apoptosis, and as a marker for activated B and T cell proliferation.

General readings

1. Harada, N., L. Santos-Argumedo, R. Chang, J. C. Grimaldi, F. E. Lund, C. I. Brannan, N. G. Copeland, N. A. Jenkins, A. W. Heath, and R. M.
Parkhouse. 1993. J. Immunol. 151:3111.
2. Santos-Argumedo, L., C. Teixeira, G. Preece, P. A. Kirkham, and R. M. E. Parkhouse. 1993. J. Immunol. 151:3119.
3. Howard, M., J. C. Grimaldi, J. F. Bazan, F. E. Lund, L. Santos-Argumedo, R. M. E. Parkhouse, T. F. Walseth, and H. C. Lee. 1993. Science 262:1056.
4. Lund, F., N. Solvason, J. C. Grimaldi, R. M. Parkhouse, and M. Howard. 1995. Immunol. Today 16:469.
5. Kirkham, P. A., L. Santos-Argumedo, M. M. Harnett, and R. M. Parkhouse. 1994. Immunology 83:513.
6. Bean, A. G. D., D. I. Godfrey, W. G. Ferlin, L. Santos-Argumedo, R. M. E. Parkhouse, M. C. Howard, and A. Zlotnik. 1996. Int. Immunol. 7:213.
7. Oliver, A. and J. Kearney. 1996. Personal Communication.
8. Kumagai, M., E. Coustan-Smith, D. J. Murray, O. Silvennoinen, K. G. Murti, W. E. Evans, F. Malavasi, and D. Campana. 1995. J. Exp. Med. 181:1101.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD38 antibody

Western blot analysis of lysate from RPMI 8226 cell line,  using CD38 Antibody (C-term)(Cat.  #TA324750).  TA324750 was diluted at 1:1000.  A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.  Lysate at 35ug. Rabbit IgG Purified Hu, Mky F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CD38 antibody

Surface staining of PHA stimulated human peripheral blood lymphocytes with anti-human CD38 (HIT2) PE. Mouse IgG1 HIT2 APC Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD38 antibody

Surface staining of PHA stimulated human peripheral blood lymphocytes with anti-human CD38 (HIT2) PE. Mouse IgG1 HIT2 Biotin Hu F
0.1 mg / €260.00
  Acris Antibodies GmbH

CD38 antibody

Surface staining of PHA stimulated human peripheral blood lymphocytes with anti-human CD38 (HIT2) PE. Mouse IgG1 HIT2 FITC Hu F
100 Tests / €260.00
  Acris Antibodies GmbH

CD38 antibody

Surface staining of PHA stimulated Human peripheral blood lymphocytes with PE conjugated anti-Human CD38 Antibody Cat.-No SM3083P (Clone HIT2). Mouse IgG1 HIT2 Purified Hu C, F, P, WB
0.1 mg / €220.00
  Acris Antibodies GmbH

CD38 antibody

Surface staining of PHA stimulated human peripheral blood lymphocytes with anti-human CD38 PE (SM3083R). Mouse IgG1 HIT2 PerCP Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD38 antibody

Surface staining of PHA stimulated Human peripheral blood lymphocytes with PE conjugated anti-Human CD38 antibody (HIT2). Mouse IgG1 HIT2 PE Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD38 antibody

Staining of BALB/c splenocytes with 0.06 ug of Rat IgG2a Isotype Control Purified (open histogram) or 0.06 ug Anti-Mouse CD38 Purified (filled histogram) followed by Anti-Rat IgG FITC .  Total viable cells were used for analysis. Rat 90 Purified Ms F
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD38 antibody

CD38 Mouse HIT2 Purified Hu F, P
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD38 (226-237) antibody

TA326737 (2µg/ml) staining of Human Spinal Cord cancer lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD38 antibody

Anti-CD38 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

CD38 antibody

Anti-CD38 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

CD38 antibody

Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-2: A549 cells, Raji cells, Primary antibody: (CD38 Antibody) at dilution 1/520, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD38 antibody

Human peripheral blood lymphocytes stained with purified HIT2, followed by anti-mouse IgGs FITC Mouse HIT2 Purified Hu F, P
0.1 mg / €248.00
  OriGene Technologies, Inc.

CD38 antibody

C57BL/6 splenocytes stained with purified 90, followed by anti-rat IgG FITC Rat 90 Purified Ms F, P
50 µg / €248.00
  OriGene Technologies, Inc.

CD38 antibody

CD38 Rabbit IgG Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD38 antibody

CD38 Rabbit IgG SP149 Purified Hu F, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD38 antibody

CD38 Mouse IgG1 TME-2 FITC Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD38 antibody

CD38 Mouse IgG1 TME-2 Purified Hu F
0.1 mg / €250.00
  Acris Antibodies GmbH

CD38 antibody

CD38 Mouse IgG1 TME-2 PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

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