CD40 antibody

Principal name

CD40 antibody

Alternative names for CD40 antibody

TNFRSF5, CDw40, Bp50, Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, CD40L receptor

SwissProt ID

P25942 (Human), P27512 (Mouse), Q28203 (Bovin), Q3ZTK5 (Horse), Q7YRL5 (Canfa), Q8SQ34 (Pig)

Gene ID

958 (CD40), 21939 (Cd40)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat), Bov (Bovine), Por (Porcine), Mky (Monkey), Rb (Rabbit), Eq (Equine), GP (Guinea Pig)

Available hosts

Mouse, Rat, Rabbit, Goat, Hamster

Available applications

Frozen Sections (C), Functional assay (FN), Flow Cytometry (F), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunohistochemistry (IHC)

Background of CD40 antibody

CD40 is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

General readings

1. Cowan RW  et al. T cells stimulate catabolic gene expression by the stromal cells from giant cell tumor of bone. Biochem Biophys Res Commun 419:719-23 (2012). IHC .
2. Manczak M  et al. Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease. Hum Mol Genet 18:3876-93 (2009). IHC-Fr ; Mouse .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD40 antibody

  CD40 mouse monoclonal antibody,clone UMAB183  
Immunohistochemical staining of paraffin-embedded Human lung tissue using anti-CD40 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 110C for 10 min, UM800075)(1:200) Mouse IgG1 UMAB183 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD40 antibody

  CD40 mouse monoclonal antibody,clone UMAB183  
Immunohistochemical staining of paraffin-embedded Human lung tissue using anti-CD40 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 110C for 10 min, UM800075)(1:200) Mouse IgG1 UMAB183 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD40 antibody

  CD40 mouse monoclonal antibody, clone OTI8B8 (formerly 8B8)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CD40 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA807569) Mouse IgG2a OTI8B8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD40 antibody

  CD40 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CD40 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807575) Mouse IgG1 OTI1F12 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD40 antibody

  CD40 mouse monoclonal antibody, clone OTI9D8 (formerly 9D8)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CD40 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807682) Mouse IgG1 OTI9D8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD40 antibody

  CD40 mouse monoclonal antibody, clone OTI5C9 (formerly 5C9)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CD40 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807683)(1:150) Mouse IgG2b OTI5C9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD40 antibody

  CD40 mouse monoclonal antibody, clone OTI9F4 (formerly 9F4)  
Immunohistochemical staining of paraffin-embedded Human colon tissue using anti-CD40 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807686)(1:150) Mouse IgG2b OTI9F4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD40 antibody

IHC staining on Bouin paraffin lymph node section. Human CD40 stained with mAb 89. Mouse IgG1 mAb89 Purified Hu C, F, FN, P
50 µg / €240.00
  Dendritics SAS

CD40 antibody

IHC staining on Bouin paraffin lymph node section. Human CD40 stained with mAb 89. Mouse IgG1 MAB89 Purified Hu C, F, FN, P
0.1 mg / €310.00
  Dendritics SAS

CD40 (Isoform 1) antibody

AP33488PU-N(1µg/ml) staining of Daudi lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD40 antibody

  Rabbit polyclonal anti-CD40 antibody  
Western blot analysis of extracts from COS7 cells, using CD40 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD40 antibody

  Rabbit polyclonal anti-CD40 antibody  
Western blot analysis of CD40 expression in rat kidney tissue lysate. Rabbit Aff - Purified Hu, Mky, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD40 antibody

  Mouse Anti-Human CD40 Purified (100 ug)  
CD40 Mouse 5C3 Purified Hu F
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD40 antibody

  Hamster Anti-Mouse/Rat CD40 Purified (100 ug)  
Staining of BALB/c splenocytes with 0.5 ug Armenian Hamster IgG Isotype Control Purified (open histogram) or 0.5 ug Anti-Mouse/Rat CD40 Purified (filled histogram) followed by Anti-Armenian Hamster IgG FITC .  Total viable cells were used for analysis. Hamster HM40-3 Purified Ms, Rt F, P
0.1 mg / €150.00
  OriGene Technologies, Inc.

CD40 antibody

  Rabbit Polyclonal Anti-CD40 Antibody  
WB Suggested Anti-CD40 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human Thymus Rabbit IgG Purified Eq, GP, Hu, Rb WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD40 antibody

  Rabbit Polyclonal Anti-CD40 Antibody  
WB Suggested Anti-CD40 Antibody Titration: 0.2-1 ug/ml; Positive Control: Raji cell lysateCD40 is strongly supported by BioGPS gene expression data to be expressed in Human Raji cells Rabbit IgG Purified Hu, Rb WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD40 antibody

  Rabbit Polyclonal Anti-CD40 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (CD40 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD40 antibody

  Mouse Monoclonal anti-CD40 Antibody  
Human peripheral blood lymphocytes stained with purified HB14, followed by anti-mouse IgGs FITC Mouse HB14 Purified Hu F
0.1 mg / €248.00
  OriGene Technologies, Inc.

CD40 antibody

  Hamster Monoclonal anti-CD40 Antibody  
C57BL/6 splenocytes stained with HM40-3 biotin, then detected with Sav-PE Hamster IgM HM40-3 Purified Ms F, P
50 µg / €248.00
  OriGene Technologies, Inc.

CD40 antibody

  Rabbit Polyclonal anti-CD40 Antibody  
CD40 Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

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