CD41 / ITGA2B antibody

Principal name

CD41 / ITGA2B antibody

Alternative names for CD41 / ITGA2B antibody

Integrin alpha-IIb, GP2B, ITGAB, GPalpha IIb, Platelet membrane glycoprotein IIb

SwissProt ID

P08514 (Human), Q9QUM0 (Mouse)

Gene ID

3674 (ITGA2B), 16399 (Itga2b)

Available reactivities

Hu (Human), Prim (Primate), Ms (Mouse), Bab (Baboon), Mky (Monkey), Mink, Por (Porcine), Chk (Chicken), Bov (Bovine), Can (Canine), Gt (Goat), Rb (Rabbit), Sh (Sheep), Rt (Rat)

Available hosts

Mouse, Rat, Rabbit

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Functional assay (FN)

Background of CD41 / ITGA2B antibody

The MWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alphaIIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin betaIII) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin. Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.

General readings

1. Debili N, Robin C, Schiavon V, Letestu R, Pflumio F, Mitjavila-Garcia MT, Coulombel L, Vainchenker W: Different expression of CD41 on human lymphoid and myeloid progenitors
from adults and neonates. Blood. 2001 Apr 1;97(7):2023-30.
3. Mitjavila-Garcia MT, Cailleret M, Godin I, Nogueira MM, Cohen-Solal K, Schiavon V, Lecluse Y, Le Pesteur F, Lagrue AH, Vainchenker W: Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development. 2002 Apr;129(8):2003-13.
4. Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC: CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development. 2003 Sep;130(18):4393-403.
5. Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf T: CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation. Exp Hematol. 2007 Mar;35(3):490-499.
6. Chen Z., Bao ZX., Yu AX. et al. (1987): A group monoclonal antibodies against human platelets with different functions. Chinese Science Bulletin. 24:1902
7. Bao CX., Chen Z., Jin XQ. et al. (1987): HIP2: A new monoclonal antibody with stimulation for human platelet. Chinese J. of Hematology. 8(2):65
8. Wu XW., Chen Z., Bao CX. et al. (1989): Production and application of anti-human platelet GPIIb/IIIa monoclonal antibodies. National Medical J. of China. 69(8):427
9. Leukocyte Typing IV., Knapp W. et al. (Eds.), Oxford University Press (1989).
10. Bao CX., Liu JW., Chen GZ. et al. (1992): Some biological characterization of monoclonal antibody HIP2 receptor on platelet membrane glycoprotein IIB. Chinese J. of Hematology.13(2):66
11. Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).
12. Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD41 / ITGA2B antibody

CD41 / ITGA2B Rat IgG1 MWReg30 Biotin Ms F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

CD41 / ITGA2B Rat IgG1 MWReg30 Biotin Ms F
25 µg / €180.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

CD41 / ITGA2B Rat IgG1 MWReg30 FITC Ms F
0.1 mg / €270.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

CD41 / ITGA2B Rat IgG1 MWReg30 FITC Ms F
25 µg / €190.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

Staining of mouse peripheral blood with rat anti-mouse CD41 Cat.-No. SM2035P. Platelets stain strongly for CD41. Rat IgG1 MWReg30 Aff - Purified Ms C, F, IP
0.25 mg / €390.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

Staining of mouse peripheral blood with rat anti-mouse CD41 Cat.-No. SM2035P. Platelets stain strongly for CD41. Rat IgG1 MWReg30 Aff - Purified Ms C, F, IP
0.1 mg / €240.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

Staining of mouse peripheral blood with rat anti-mouse CD41 Cat.-No. SM2035P. Platelets stain strongly for CD41. Rat IgG1 MWReg30 Aff - Purified Ms C, F, IP
25 µg / €170.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

Sample (30 ug of whole cell lysate). A: A549. 7.5% SDS PAGE. TA308579 diluted at 1:500. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD41 / ITGA2B antibody

Staining of mouse platelets with 0.125 ug of Rat IgG1 Isotype Control  Purified (left) or 0.125 ug of Anti-Mouse CD41  Purified (right) followed by Anti-Rat IgG PE . Rat eBioMWReg30 (MWReg30) Purified Ms E, F, IP
50 µg / €120.00
  OriGene Technologies, Inc.

CD41 / ITGA2B antibody

Western blot analysis of extracts of various cell lines, using ITGA2B antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD41 / ITGA2B antibody

Staining of human peripheral blood platelets with mouse anti human CD41 Mouse IgG2b MM2/356 Purified Hu, Mink, Por F, IP
2 ml / €460.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

Immunohistochemistry on frozen sections: Staining with AM26055PU-N on human placenta Mouse IgG1 96.2C1 Aff - Purified Hu C, F
0.2 mg / €280.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

CD41 / ITGA2B Mouse IgG1 CA3 Ig Fraction Hu C, E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

CD41 / ITGA2B (alpha) antibody

CD41 / ITGA2B Rabbit Purified Hu, Ms C, E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

CD41 / ITGA2B Mouse IgG1 SZ.22 FITC Hu C, F, ICC/IF
100 Tests / €780.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

CD41 / ITGA2B Mouse IgG1 PM6/248 Azide Free Hu F
1 mg / €790.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

Staining of human peripheral blood platelets with Mouse Anti Human CD41-FITC (SM1108F/FT). Mouse IgG1 PM6/248 FITC Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

CD41 / ITGA2B Mouse IgG1 PM6/248 Purified Hu F
0.2 mg / €430.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

CD41 / ITGA2B Mouse IgG1 PM6/248 Purified Hu F
0.1 mg / €270.00
  Acris Antibodies GmbH

CD41 / ITGA2B antibody

CD41 / ITGA2B Mouse IgG1 PM6/248 Purified Hu, Mky F
25 µg / €180.00
  Acris Antibodies GmbH

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