CD42c / GPIbB antibody

Principal name

CD42c / GPIbB antibody

Alternative names for CD42c / GPIbB antibody

Platelet glycoprotein Ib beta chain, GP-Ib beta, GPIb-beta

SwissProt ID

P13224 (Human), P56400 (Mouse), Q9JJM7 (Rat)

Gene ID

2812 (GP1BB), 14724 (Gp1bb), 116727

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F)

Background of CD42c / GPIbB antibody

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane sigling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Berrd-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mR expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mR species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA sigl within a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its own imperfect site, the septin 5 gene uses the consensus polyA sigl of this gene. [provided by RefSeq]

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD42c / GPIbB antibody

  Rabbit polyclonal antibody to CD42c (glycoprotein Ib (platelet), beta polypeptide)  
Sample (30 ug of whole cell lysate). A: Raji. 12% SDS PAGE. TA308259 diluted at 1:1000. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD42c / GPIbB antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Hu P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Gp1bb - mouse gene knockout kit via CRISPR

Gp1bb - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Gp1bb - mouse gene knockout kit via CRISPR

Gp1bb - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gp1bb - mouse gene knockout kit via CRISPR

Gp1bb - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gp1bb - mouse gene knockout kit via CRISPR

Gp1bb - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GP1BB (mGFP-tagged)-Human glycoprotein Ib (platelet), beta polypeptide (GP1BB), 200 uL, >10^7 TU/mL

Lenti ORF particles, GP1BB (mGFP-tagged)-Human glycoprotein Ib (platelet), beta polypeptide (GP1BB), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, GP1BB (Myc-DDK-tagged)-Human glycoprotein Ib (platelet), beta polypeptide (GP1BB), 200 uL, >10^7 TU/mL

Lenti ORF particles, GP1BB (Myc-DDK-tagged)-Human glycoprotein Ib (platelet), beta polypeptide (GP1BB), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Gp1bb (GFP-tagged) - Mouse glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Gp1bb (GFP-tagged) - Mouse glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Gp1bb (GFP-tagged) - Mouse glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Gp1bb (GFP-tagged) - Mouse glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Gp1bb (Myc-DDK-tagged) - Mouse glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Gp1bb (Myc-DDK-tagged) - Mouse glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, Gp1bb (Myc-DDK-tagged) - Mouse glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Gp1bb (Myc-DDK-tagged) - Mouse glycoprotein Ib, beta polypeptide (Gp1bb), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Gp1bb (GFP-tagged ORF) - Rat glycoprotein Ib (platelet), beta polypeptide (Gp1bb), 200 uL, >10^7 TU/mL

Lenti ORF particles, Gp1bb (GFP-tagged ORF) - Rat glycoprotein Ib (platelet), beta polypeptide (Gp1bb), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Gp1bb (Myc-DDK-tagged ORF) - Rat glycoprotein Ib (platelet), beta polypeptide (Gp1bb), 200 uL, >10^7 TU/mL

Lenti ORF particles, Gp1bb (Myc-DDK-tagged ORF) - Rat glycoprotein Ib (platelet), beta polypeptide (Gp1bb), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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