CD42c / GPIbB antibody

Principal name

CD42c / GPIbB antibody

Alternative names for CD42c / GPIbB antibody

Platelet glycoprotein Ib beta chain, GP-Ib beta, GPIb-beta

SwissProt ID

P13224 (Human), P56400 (Mouse), Q9JJM7 (Rat)

Gene ID

2812 (GP1BB)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of CD42c / GPIbB antibody

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal within a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its own imperfect site, the septin 5 gene uses the consensus polyA signal of this gene. [provided by RefSeq]

7 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD42c / GPIbB antibody

Sample (30 ug of whole cell lysate). A: Raji. 12% SDS PAGE. TA308259 diluted at 1:1000. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD42c / GPIbB antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Hu P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CD42c / GPIbB antibody

CD42c / GPIbB Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

CD42c / GPIbB antibody

Western blot analysis of CD42c expression in Raji (A); HL60 (B); SP2/0 (C); rat heart (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CD42c / GPIbB antibody

Western blot analysis of CD42c expression in Raji (A); HL60 (B); SP2/0 (C); rat heart (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CD42c / GPIbB antibody

Western blot analysis of CD42c expression in Raji (A); HL60 (B); SP2/0 (C); rat heart (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CD42c / GPIbB antibody

CD42c / GPIbB Rabbit IgG Hu WB
0.1 ml / €420.00
  Novus Biologicals Inc.

7 Item(s)

per page
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