CD44 antibody

Principal name

CD44 antibody

Alternative names for CD44 antibody

LHR, MDU2, MDU3, MIC4, CDw44, Epican, ECMR-III, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, PGP-1, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, Phagocytic glycoprotein 1

SwissProt ID

P15379 (Mouse), P16070 (Human), P20944 (Crigr), P26051 (Rat), Q05078 (Horse), Q28284 (Canfa), Q29423 (Bovin), Q60522 (Mesau), Q9W6S4 (Chick)

Gene ID

960 (CD44), 12505 (Cd44), 100034221, 9332 (CD163)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Por (Porcine), Mky (Monkey), Eq (Equine), Bov (Bovine), Gt (Goat), Sh (Sheep), Fe (Feline), Chk (Chicken), Rb (Rabbit), Bab (Baboon)

Available hosts

Mouse, Rabbit, Rat, Goat

Available applications

Functional assay (FN), Immunoprecipitation (IP), Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Cytotoxicity Assay (CT), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Neutralisation (NEUT), Luminex (LMNX)

Background of CD44 antibody

The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95kD or hematopoietic variant (CD44s) that is found in mesodermal cells such as hematopoietic, fibroblastic, and glial cells, and in some carcinoma cell lines. Higher molecular weight isoforms have been described in epithelial cells (CD44v) and are thought to function in intercellular adhesion and stromal binding. While the other functions and distributions of the CD44 family have not yet been completely elucidated they are also known to participate in embryonic development and angiogenesis as well as other molecular processes associated with specific adhesions, signal transduction, and cell migration. The recent demonstration of a concordance of the cell proliferation nuclear antigen, Ki-67, and CD44 expression in adenomatous polyps, colonic carcinomas and adjacent mucosa raises the possibility of involvement of CD44 in stimulating cell growth.
It appears that the CD44-hyaluronate interaction is central to tumor invasiveness; the receptor allowing the uptake and subsequent degradation of metrical hyaluronate. While many human tumors express CD44, a positive correlation between increased CD44v expression and tumor progression and/or dedifferentiation has been demonstrated in only some. Such tumors include non-Hodgkin’s lymphoma (Stauder et al, 1995), hepatocellular carcinoma (Matthew et al, 1996), breast carcinoma, renal cell carcinoma (terpe et al, 1993), colonic carcinoma (Abassi et al, 1993; Wielenga et al, 1993; Herrlich et al, 1995) and some soft tissue tumors (Wand et al, 1996). More recent additions to the list include metastatic melanoma (Sviatoha, et al, 2002), prostatic carcinoma (Ekici et al, 2002), and gastric cancer (Yamaguchi et al, 2002). Conversely, CD44v expression is downgraded in other tumors including neuroblastoma (Shtivelman & Bisho, 1991), squamous cell and basal cell carcinomas of the skin (Herold-Mende et al, 1996).
The suggestion that there is a positive association between CD44 isoform expression and progression in human tumors has important implications for diagnosis and prognosis. Unfortunately, the situation is not yet clear-cut. Confusion over the complicated exon boundaries together with the different nomenclature employed by researchers have added to problems of identifying the true metastasis-associated isoforms. Furthermore, stromal cells may contribute to the isoform pattern detected. Probably the most practical application of CD44 immunostaining at present is the discrimination of urothelial transitional call carcinoma-in-situ from non-neoplastic changes in the urothelium (McKenney JK, et al. 2001).

General readings

1. Vigetti D, Viola M, Karousou E, Rizzi M, Moretto P, Genasetti A, Clerici M, Hascall VC, De Luca G, Passi A: Hyaluronan-CD44-ERK1/2 regulate human aortic smooth muscle cell motility during aging. J Biol Chem. 2007 Dec 12
2. Hollingsworth JW, Li Z, Brass DM, Garantziotis S, Timberlake SH, Kim A, Hossain I, Savani RC, Schwartz DA. CD44 regulates macrophage recruitment to the lung in
lipopolysaccharide-induced airway disease. Am J Respir Cell Mol Biol. 2007 Aug;37(2):248-53.
3. Liu J, Bi G, Wen P, Yang W, Ren X, Tang T, Xie C, Dong W, Jiang G. Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
4. Subramaniam V, Gardner H, Jothy S: Soluble CD44 secretion contributes to the acquisition of aggressive tumor phenotype in human colon cancer cells. Exp Mol Pathol. 2007 Dec;83(3):341-6.
5. Subramaniam V, Vincent IR, Gardner H, Chan E, Dhamko H, Jothy S: CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation. Exp Mol
Pathol. 2007 Oct;83(2):207-15.
6. Leukocyte Typing III., McMichael A.J. et al. (Eds.), Oxford University Press (1987).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD44 antibody

CD44 Rat IgG2b IM7.8.1 Biotin Ms F
0.1 mg / €250.00
  Acris Antibodies GmbH

CD44 antibody

CD44 Rat IgG2b IM7.8.1 Biotin Ms F
0.3 mg / €500.00
  Acris Antibodies GmbH

CD44 antibody

Cell Source: Peripheral Blood Leukocytes. Percentage of cells stained above control: 54.8% Rat IgG2b IM7.8.1 FITC Ms F
0.1 mg / €280.00
  Acris Antibodies GmbH

CD44 antibody

Cell Source: Peripheral Blood Leukocytes. Percentage of cells stained above control: 54.8% Rat IgG2b IM7.8.1 FITC Ms F
0.3 mg / €440.00
  Acris Antibodies GmbH

CD44 antibody

CD44 Rat IgG2b IM7.8.1 Purified Ms C, E, F, IP, P, WB
0.2 mg / €340.00
  Acris Antibodies GmbH

CD44 antibody

Cell Source: Spleen. Percentage of cells stained above control: 87.4% Rat IgG2b IM7.8.1 PE Ms F
50 µg / €260.00
  Acris Antibodies GmbH

CD44 antibody

Cell Source: Spleen. Percentage of cells stained above control: 87.4% Rat IgG2b IM7.8.1 PE Ms F
0.3 mg / €780.00
  Acris Antibodies GmbH

CD44 antibody

Staining of equine peripheral blood lymphocytes with CD44 antibody clone CVS18 Cat.-No. SM502F. Mouse IgG1 CVS18 FITC Eq F
0.1 mg / €440.00
  Acris Antibodies GmbH

CD44 antibody

Staining of equine peripheral blood lymphocytes with CD44 antibody clone CSV18 Cat.-No. SM502PS, followed by FITC conjugated goat anti mouse IgG. Mouse IgG1 CVS18 Purified Eq C, F
0.1 mg / €390.00
  Acris Antibodies GmbH

CD44 antibody

CD44 Mouse IgG1 CVS18 PE Eq F
100 Tests / €500.00
  Acris Antibodies GmbH

CD44 antibody

Immunohistochemical staining of paraffin-embedded Human thyroid tissue using anti-CD44 mouse monoclonal antibody. (UM500098; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB133 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD44 antibody

Immunohistochemical staining of paraffin-embedded Human thyroid tissue using anti-CD44 mouse monoclonal antibody. (UM500099; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB134 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD44 antibody

Immunohistochemical staining of paraffin-embedded Human thyroid tissue using anti-CD44 mouse monoclonal antibody. (UM500098; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB133 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD44 antibody

Immunohistochemical staining of paraffin-embedded Human thyroid tissue using anti-CD44 mouse monoclonal antibody. (UM500099; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB134 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD44 antibody

CD44 antibody detects CD44 protein by western blot analysis. A. 30 ug A549 whole cell lysate/extract. B. 30 ug H1299 whole cell lysate/extract. 7.5 % SDS-PAGE. CD44 antibody (TA308864) dilution: 1:5000 Rabbit IgG Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD44 antibody

Western Blot: CD44 Antibody (8E2F3) [TA336769] - Western blot analysis using anti-CD44 mAb against Hela (1) and HUVE-12 (2) cell lysates. Mouse IgG1 8E2F3 Purified Hu, Ms C, E, F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD44 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-CD44 mouse monoclonal antibody. (TA506725; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG1 OTI1E3 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD44 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-CD44 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506726) Mouse IgG1 OTI1D8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD44 antibody

Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-CD44 mouse monoclonal antibody. (TA506727; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG1 OTI1C8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD44 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-CD44 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506732) Mouse IgG2a OTI1G1 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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