CD46 / MCP antibody

Principal name

CD46 / MCP antibody

Alternative names for CD46 / MCP antibody

TLX, MIC10, Membrane cofactor protein, Trophoblast leukocyte common antigen

SwissProt ID

O02839 (Pig), O88174 (Mouse), P15529 (Human), Q6VE48 (Bovin), Q9Z0M4 (Rat)

Gene ID

4179 (CD46), 396922, 854179 (RTS1), 17221 (Cd46), 29333

Available reactivities

Hu (Human), Bov (Bovine), Por (Porcine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Paraffin Sections (P), Functional assay (FN)

Background of CD46 / MCP antibody

CD46, also known as membrane cofactor protein (MCP), was first described as a membrane complement regulator that fu nctions as a cofactor with factor I to cleave complement factors C3b and C4b and thereby protect the cell from co mplement attack. In humans, CD46 is expressed on all nuc leated cells. In the rodent animals, its expression is limited only in testis, indicating that the major function of CD46 among different species lies in fertilization. CD46 and other membrane complement regulatory proteins (CD55 and CD59) are frequently overexpressed on cancer cells, possibly as a mechanism for cancer cells to overcome lysis by complement. Several pathogens, including viruses and bacteria (measles virus, human herpesvirus 6, human group B and D adenoviruses, Streptococcus pyogenes , and pathogenic Neisseria species) have been reported to use CD46 for invasion. Recent evidence also indicates that CD 46 signaling events play an important role in linking innate and acquired immune function.

General readings

Hara T et al. Soluble forms of membrane cofactor protein (CD46, MCP) are present in plasma, tears, and seminal fluid in normal subjects. Clin Exp Immunol 89:490-4 (1992). PubMed: 1516264
Liszewski MK et al. Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annu Rev Immunol 9:431-55 (1991). PubMed: 1910685
Search PubMed (MEDLINE) for references to CD46

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD46 / MCP antibody

Table 1. Tissue distribution of CD46 (Johnstone et al., modified) Mouse IgG1 13/42 Purified Hu C, F, IP, WB
0.2 mg / €370.00
  Acris Antibodies GmbH

CD46 / MCP antibody

Western blot analysis of extracts of various cell lines, using CD46 antibody. Rabbit IgG Purified Hu, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD46 / MCP antibody

Western blot analysis of lysates from Jurkat,SK-BR-3 cell line (from left to right),using CD46 Antibody (C-term)(Cat. #TA324791).TA324791 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane. Rabbit IgG Purified Hu F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CD46 / MCP antibody

CD46 Antibody (Y354) (Cat. #TA328132) western blot analysis in A549,Hela cell line lysates (35ug/lane).This demonstrates the CD46 antibody detected the CD46 protein (arrow). Rabbit Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CD46 / MCP antibody

ELISA: CD46 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD46 / MCP antibody

Staining of porcine peripheral blood granulocytes with Mouse anti Porcine CD46 antibody Cat.-No AM05560PU-N Mouse IgG1 6D8/8 Purified Por F, IP, WB
0.25 mg / €530.00
  Acris Antibodies GmbH

CD46 / MCP antibody

Staining of porcine peripheral blood lymphocytes with Mouse anti Porcine CD46 (Cat.-No AM05945PU-N) Mouse IgG1 JM6C11 Purified Por F
0.25 mg / €530.00
  Acris Antibodies GmbH

CD46 / MCP antibody

Placenta stained in Immunohistochemistry on Paraffin Sections with CD46 antibody Cat.-No AM10193PU-N Mouse IgG1 3F1 Purified Hu E, P, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

CD46 / MCP (SCR2 Dom.) antibody

CD46 / MCP Mouse IgG1 M177 Purified Hu E, FN, IP, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

CD46 / MCP antibody

Flow cytometric analysis of CD46 expression on HPB-ALL. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26547AF-N to the cells. Mouse IgG2a TGP3 Azide Free Hu F, IP
0.1 mg / €340.00
  Acris Antibodies GmbH

CD46 / MCP antibody

Flow cytometric analysis of CD46 expression on human lymphocyte (R1), monocyte (R2) and granulocyte (R3) using AM26547FC-S. Open histograms indicate the reaction of isotypic control to the cells. Shaded histograms indicate the reaction of AM26547FC-S to the cells. Mouse IgG2a TGP3 FITC Hu F
0.1 ml / €390.00
  Acris Antibodies GmbH

CD46 / MCP (SCR2 Dom.) antibody

CD46 / MCP Mouse IgG1 M177 Liquid Hu C, E, FN, IP, P, WB
0.1 mg / €590.00
  Acris Antibodies GmbH

CD46 / MCP antibody

CD46 / MCP Rat IgG2a MM10 Purified Ms, Rt E, F, ICC/IF, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CD46 / MCP antibody

Immunohistochemical staining of Rat Kidney Frozen sections with CD46 antibody Clone MM.1 Mouse IgG1 MM.1 Purified Rt C, E, ICC/IF, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CD46 / MCP antibody

FCM staining of human PBMCs using CD46 Antibody (Clone 122.2). Mouse IgG1 122.2  Purified Hu C, F, FN, ICC/IF, IP, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

CD46 / MCP antibody

FCM staining of human PBMCs using CD46 Antibody (Clone 122.2). Mouse IgG1 122.2  Purified Hu C, F, FN, ICC/IF, IP, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD46 / MCP antibody

FCM staining of human PBMCs using CD46 Antibody (Clone 122.2). Mouse IgG1 122.2  Purified Hu C, F, FN, ICC/IF, IP, WB
20 µg / €160.00
  Acris Antibodies GmbH

CD46 / MCP antibody

The cell lysates of Ramos, HeLa and A549 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CD46 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2a AT2G9 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

CD46 / MCP antibody

The cell lysates of Ramos, HeLa and A549 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CD46 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2a AT2G9 Purified Hu E, WB
50 µl / €220.00
  Acris Antibodies GmbH

CD46 / MCP antibody

Surface staining of human peripheral blood cells with anti-CD46 (MEM-258) PE Mouse IgG1 MEM-258 APC Bov, Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

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