CD49b / ITGA2 antibody

Principal name

CD49b / ITGA2 antibody

Alternative names for CD49b / ITGA2 antibody

Integrin alpha-2, ITGA-2, VLA-2 alpha, VLA2, GPIa, Collagen Receptor, Platelet membrane glycoprotein Ia, CD49 antigen-like family member B

SwissProt ID

P17301 (Human), P53710 (Bovin), Q62469 (Mouse)

Gene ID

3673 (ITGA2), 3674 (ITGA2B), 16398

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Bab (Baboon), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Chk (Chicken)

Available hosts

Mouse, Rabbit, Rat, Hamster, Human

Available applications

Functional assay (FN), Flow Cytometry (F), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), MAIPA Assay (MAIPA)

Background of CD49b / ITGA2 antibody

The monoclonal antibody DX5 reacts with CD49b, also known as very late antigen-2 (VLA-2) and alpha2 integrin. (1) The antibody stains the majority of NK cells and a small subpopulation of T cells in all mouse strains tested (e.g., A/J, AKR, BALB/c, C3H/HeJ, C57BL/6, C57BL/10, C57BR, C58, CBA/Ca, CBA/J, DBA/1, DBA/2, SJL, SWR). (2. 3) Three-color flow cytometry analysis has revealed that most cells that express NK-1.1 (NKR-P1C) also express CD49b. However, small subsets of DX5+NK-1.1- and DX5-NK- 1.1+ cells can be found, especially among the CD3+ population of T lymphocytes. (2) NK cells cultured in the presence of IL-2 progressively lose reactivity with DX5 as a consequence of cellular proliferation. (1) Therefore, DX5 can be used to define functionally distinct subsets of murine NK cells. The monoclonal antibody DX5 has not been demonstrated to have activating or blocking activity. (2)

General readings

General / background references:Owens DM & Watt FM Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion. Cancer Res 61:5248-54 (2001). PubMed PMID: 11431366
Levy L et al. beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms. Mol Biol Cell 11:453-66 (2000). PubMed PMID: 10679006
Alford D et al. Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels. J Cell Sci 111 Pt 4:521-32 (1998). PubMed PMID: 9443900
Sugiyama M et al. Comparison of integrin expression and terminal differentiation capacity in cell lines derived from oral squamous cell carcinomas. Carcinogenesis 14:2171-6 (1993). PubMed PMID: 7693359
Tenchini ML et al. Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes. Cell Adhes Commun 1:55-66 (1993). PubMed PMID: 7521749

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD49b / ITGA2 antibody

Staining of BALB/c splenocytes with 0.25 ug of Armenian Hamster IgG Isotype Control Purified (open histogram) or 0.25 ug of Anti-Mouse CD49b Purified (filled histogram) followed by Anti-Armenian Hamster IgG FITC .  Cells in the lymphocyte gate were used for analysis. Hamster HMa2 Purified Ms F, IP, P
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD49b / ITGA2 antibody

WB Suggested Anti-ITGA2 Antibody; Titration: 1.0 ug/ml; Positive Control: HT1080 Whole Cell ITGA2 is supported by BioGPS gene expression data to be expressed in HT1080 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt ICC/IF, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD49b / ITGA2 antibody

Anti-ITGA2 / CD49b antibody IHC of human colon, surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

CD49b / ITGA2 antibody

Anti-ITGA2 / CD49b antibody IHC of human thymus, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

CD49b / ITGA2 antibody

CD49b / ITGA2 Rat IgM DX5 Biotin Ms F
0.1 mg / €310.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

Splenocytes from a C57BL/6 SCID mouse double stained with RAT ANTI MOUSE 
CD49b-FITC and Mouse Anti Mouse NK1.1-R-PE Cat.-No AM01268FC-N. Rat IgM DX5 FITC Ms F
0.1 mg / €320.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

CD49b / ITGA2 Rat IgM DX5 FITC Ms F
25 µg / €190.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

CD49b / ITGA2 Rat IgM DX5 Purified Ms F
0.25 mg / €390.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

CD49b / ITGA2 Rat IgM DX5 Purified Ms F
25 µg / €170.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

CD49b / ITGA2 Mouse IgG2a HAS-4 Purified Hu F, IP
0.1 mg / €190.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

CD49b / ITGA2 Mouse IgG2a HAS-4 PE Hu F
100 Tests / €330.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

CD49b / ITGA2 Mouse IgG1 CLB-150 Purified Hu C, FN, ICC/IF, MAIPA, WB
1 ml / €480.00
  Acris Antibodies GmbH

CD49b / ITGA2 (C-term) antibody

Western blot analysis of CD49b / ITGA2 Antibody (C-term) Cat.-No AP52250PU-N in MDA-MB231 cell line lysates (35ug/lane). ITGA2 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

CD49b / ITGA2 Mouse IgG1 Gi9 Azide Free Hu F, FN
0.2 mg / €670.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

CD49b / ITGA2 Mouse IgG1 A.1.43 Purified Hu C
0.1 mg / €390.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

CD49b / ITGA2 Mouse IgG1 AK7 Biotin Hu, Mky F
0.1 mg / €420.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

CD49b / ITGA2 Mouse IgG1 AK7 Biotin Hu, Mky F
25 µg / €210.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

Staining of human peripheral blood platelets with Mouse Anti Human CD49b-FITC (SM1125F/FT). Mouse IgG1 AK7 FITC Hu, Mky F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

Staining of human peripheral blood platelets with Mouse Anti Human CD49b-FITC (SM1125F/FT). Mouse IgG1 AK7 FITC Hu, Mky F
25 µg / €190.00
  Acris Antibodies GmbH

CD49b / ITGA2 antibody

CD49b / ITGA2 Mouse IgG1 AK7 Low Endotoxin Hu, Mky C, F, FN
0.5 mg / €560.00
  Acris Antibodies GmbH

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