CD49d / ITGA4 antibody

Principal name

CD49d / ITGA4 antibody

Alternative names for CD49d / ITGA4 antibody

Integrin alpha-4, Integrin alpha-IV, VLA-4, VLA4, CD49 antigen-like family member D

SwissProt ID

P13612 (Human), Q00651 (Mouse)

Gene ID

16401 (Itga4), 3676 (ITGA4)

Available reactivities

Ms (Mouse), Hu (Human), Bov (Bovine), Mky (Monkey), Por (Porcine), Rt (Rat), Bab (Baboon)

Available hosts

Rat, Mouse, Rabbit

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F), Functional assay (FN), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of CD49d / ITGA4 antibody

Integrin α4 (also called CD49d) is a ~150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin α4 forms heterodimers with integrins β1 and β7. Integrin α4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin α4 promotes cell migration and inhibits cell spreading and contractility. Integrin α4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin α4 function has become an important target for drug discovery. Phosphorylation of the serine 988 residue on the integrin α4 cytoplasmic tail inhibits its interaction with the focal adhesion complex-associated protein paxillin, and modulates its effects on cell motility and spreading.

General readings

1. Quackenbush, E.J. and Letarte, J. (1985). Identification of several cell surface proteins of non-T, non-B Acute lymphoblastic Leukaemia by using monoclonal antibodies.
J. Immunol. 134: 1276-1285.
2. Letarte, M., Seehafer, J.G., Greaves, A., Masellis-Smith, A. and Shaw, A.R.E. (1992). Homotypic aggregation of pre-B Leukaemic cell lines by antibodies to VLA Integrins correlates with their expression of CD9.
Leukemia 7(1): 93-103.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD49d / ITGA4 antibody

Western blot analysis using ITGA4 antibody Cat.-No AM06742PU-N against human ITGA4 (AA: 926-978) recombinant protein (Expected MW is 31.7 kDa Mouse IgG1 5C4 Purified Hu E, F, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

CD49d / ITGA4 (C-term) antibody

  Rabbit Polyclonal Integrin alpha 4 Antibody  
Western blot analysis of Integrin alpha 4 in Jurkat cell lysate with Integrin alpha 4 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD49d / ITGA4 (Center) antibody

  Rabbit Polyclonal Integrin alpha 4 Antibody  
Western blot analysis of Integrin alpha 4 using (A) 25 and (B) 100 ng of recombinant Integrin alpha 4 with Integrin alpha 4 antibody at 1 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD49d / ITGA4 (Center) antibody

  Rabbit Polyclonal Integrin alpha 4 Antibody  
Western blot analysis of Integrin alpha 4 in rat spleen tissue lysate with Integrin alpha 4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD49d / ITGA4 antibody

  Rat Anti-Mouse CD49d (Integrin alpha 4) Purified (50 ug)  
Staining of mouse splenocytes with Anti-Mouse CD49d PE.  Appropriate isotype controls were used  (open histogram). Total viable cells were used for analysis. Rat R1-2 Purified Ms F, IP, P
50 µg / €120.00
  OriGene Technologies, Inc.

CD49d / ITGA4 antibody

  Anti-ITGA4 Rabbit Polyclonal Antibody  
Predicted band size: 70; 140; 180 kDa . Positive control: Jurkat and Raji cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1,2 : Jurkat and Raji cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD49d / ITGA4 antibody

  Rabbit Polyclonal Integrin alpha4 Antibody  
Western blot analysis of Integrin alpha4 expression in PMA treated Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD49d / ITGA4 antibody

  Rabbit Polyclonal Anti-ITGA4 Antibody (C-Terminus)  
Anti-ITGA4 / Integrin Alpha 4 antibody IHC of human thymus, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

CD49d / ITGA4 antibody

  Rabbit Polyclonal Anti-ITGA4 Antibody (Internal)  
Anti-VLA-4 / CD49D antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10-20 ug/ml. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

CD49d / ITGA4 antibody

  Rat Monoclonal anti-CD49d Antibody  
CD49d / ITGA4 Rat 9C10(MFR4.B) Purified Ms F, P
50 µg / €248.00
  OriGene Technologies, Inc.

CD49d / ITGA4 antibody

  Mouse Monoclonal anti-CD49d Antibody  
Human peripheral blood lymphocytes stained with purified 9F10, followed by anti-mouse IgGs FITC Mouse 9F10 Purified Bab, Hu F, P
0.1 mg / €248.00
  OriGene Technologies, Inc.

CD49d / ITGA4 antibody

Western blot (WB) analysis of ITGA4 antibody (Cat.-No.: AP01224PU-N) in extracts from Jurkat cells treated with PMA 125ng/ml. Rabbit Aff - Purified Hu, Ms WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD49d / ITGA4 (C-term) antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD49d / ITGA4 antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD49d / ITGA4 (C-term) antibody

Immunohistochemical analysis of paraffin embedded Mammary cancer sections, staining ITGA4 in cytoplasm, DAB chromogenic reaction Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CD49d / ITGA4 antibody

CD49d / ITGA4 Mouse IgG1 BU49 FITC Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD49d / ITGA4 antibody

CD49d / ITGA4 Mouse IgG1 Bu49 FITC Hu F
25 µg / €190.00
  Acris Antibodies GmbH

CD49d / ITGA4 antibody

CD49d / ITGA4 Mouse IgG1 Bu49 Purified Hu C, F, IP
25 µg / €180.00
  Acris Antibodies GmbH

CD49d / ITGA4 antibody

Cell Source: TK1 Cells; 
Percentage of cells stained above control: 99.3% Rat IgG2b R1-2 Ascites Ms C, F, IP
0.5 ml / €500.00
  Acris Antibodies GmbH

CD49d / ITGA4 antibody

Cell Source: TK1 Cells; 
Percentage of cells stained above control: 99.3% Rat IgG2b R1-2 Biotin Ms C, F
0.1 mg / €230.00
  Acris Antibodies GmbH

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