CD49e / ITGA5 antibody

Principal name

CD49e / ITGA5 antibody

Alternative names for CD49e / ITGA5 antibody

Integrin alpha-5, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, VLA5, FNRA, CD49 antigen-like family member E

SwissProt ID

P08648 (Human), P11688 (Mouse), Q27977 (Bovin), Q80YP5

Gene ID

3678 (ITGA5), 16402

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat), Mky (Monkey), Bov (Bovine), Rb (Rabbit)

Available hosts

Mouse, Rat, Hamster, Rabbit

Available applications

Frozen Sections (C), Flow Cytometry (F), Immunoprecipitation (IP), Functional assay (FN), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD49e / ITGA5 antibody

Integrins are transmembrane glycoproteins that belong to the family of adhesion molecules. They promote interactions between cells and their environment, being both other cells or the extra- cellular matrix. Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated subunits, i.e. an α-subunit of 95 kDa that is conserved through the superfamily and a more variable β subunit of 150-170 kDa. More than 18 α and 8 β subunits with numerous splice variant isoforms have been identified in mammals. The integrin α5 chain (160 kDa) (CD49e), undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light (25 kDa) and heavy (135 kDa) chains, which non-covalently associate with the integrin β1 subunit (CD29) (130 kDa), thus forming the heterodimer α5-β1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor (FNr) that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5 mediates binding of T- and B-cells to fibronectin, an extracellular matrix glycoprotein involved in cell adhesion and migration in wound healing, embryonic development and malignant transformation. The VLA-5 or FNr binds only fibronectin recognizing the Arg-Gly-Asp (RGD) sequence in the central region of the molecule.

General readings

Hutton, M.L., et al. Infect. Immun. 78(11):4523-4531(2010)
Fang, Z., et al. J. Cell. Biochem. 110(5):1130-1141(2010)
Lobert, V.H., et al. Dev. Cell 19(1):148-159(2010)
Caicedo-Carvajal, C.E., et al. PLoS ONE 5 (7), E11830 (2010)
Dingemans, A.M., et al. Mol. Cancer 9, 152 (2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD49e / ITGA5 antibody

Human Heart, capillaries: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 10F6 Ascites Hu E, F, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CD49e / ITGA5 antibody

Immunostaining of CTB aggregates that have invaded Matrigel in vitro, with either anti-integrin-a5 or control IgG antibody. Rat IgG2b Purified Bov, Hu, Rb F, ICC/IF, IP, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD49e / ITGA5 antibody

Western blot analysis of extracts from 3T3 cells, treated with etoposide (25uM, 24hours), using ITGA5 (heavy chain, Cleaved-Phe42) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD49e / ITGA5 antibody

Western blot analysis of extracts from 293 cells treated with etoposide (25uM, 1hour) and A549 cells treated with etoposide (25uM, 1hour), using ITGA5 (light chain, Cleaved-Glu895) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD49e / ITGA5 antibody

Staining of C57Bl/6 bone marrow cells with 0.5 ug of Armenian Hamster IgG Isotype Control Purified (left) or 0.5 ug of Anti-Mouse/Rat CD49e (Integrin alpha 5) Purified (right) followed by Anti-Armenian Hamster IgG FITC .  Total viable cells were used for analysis. Hamster eBioHMa5-1 (HMa5-1) Purified Ms, Rt F
50 µg / €120.00
  OriGene Technologies, Inc.

CD49e / ITGA5 antibody

Staining of normal human peripheral blood cells with 0.25 ug of Mouse IgG1 kappa Isotype Control Purified (open histogram) or 0.25 ug  of Anti-Human CD49e (Integrin alpha 5) Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE .  Cells in the lymphocyte gate were used for analysis. Mouse eBioSAM-1 (SAM-1, SAM1) Purified Hu F
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD49e / ITGA5 antibody

Western blot analysis of Integrin a5(CD49e) expression in HeLa cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD49e / ITGA5 antibody

Immunohistochemical analysis of paraffin-embedded human Placenta tissues using ITGA5 mouse mAb Mouse IgG2a 10F6 Ascites Hu E, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

CD49e / ITGA5 antibody

CD49e / ITGA5 Rat IgG2a 5H10-27 Biotin Ms F
0.5 mg / €330.00
  Acris Antibodies GmbH

CD49e / ITGA5 antibody

CD49e / ITGA5 Rat IgG2a 5H10-27 FITC Ms F
0.5 mg / €390.00
  Acris Antibodies GmbH

CD49e / ITGA5 antibody

CD49e / ITGA5 Rat IgG2a 5H10-27 FITC Ms F
0.1 mg / €190.00
  Acris Antibodies GmbH

CD49e / ITGA5 antibody

CD49e / ITGA5 Rat IgG2a 5H10-27 Low Endotoxin Ms C, F, FN
0.5 mg / €360.00
  Acris Antibodies GmbH

CD49e / ITGA5 antibody

CD49e / ITGA5 Rat IgG2a 5H10-27 Purified Ms C, F, FN
0.5 mg / €310.00
  Acris Antibodies GmbH

CD49e / ITGA5 antibody

CD49e / ITGA5 Rat IgG2a 5H10-27 PE Ms F
0.1 mg / €310.00
  Acris Antibodies GmbH

CD49e / ITGA5 antibody

CD49e / ITGA5 Mouse IgG2b CLB-705 Purified Hu FN, ICC/IF
1 ml / €480.00
  Acris Antibodies GmbH

CD49e / ITGA5 antibody

Flow Cytometric analysis of human monocytes showing CD49e positive population Mouse IgG2b NKI-SAM1 Purified Hu C, F
1 ml / €240.00
  Acris Antibodies GmbH

CD49e / ITGA5 (Center) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue reacted with CD49e / ITGA5 Antibody (Center) Cat.-No AP52251PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD49e / ITGA5 antibody

CD49e / ITGA5 Mouse IgG1 X-6 Purified Hu C, F
0.1 mg / €420.00
  Acris Antibodies GmbH

CD49e / ITGA5 antibody

CD49e / ITGA5 Mouse IgG1 X-6 Biotin Hu C, F
0.1 mg / €460.00
  Acris Antibodies GmbH

CD49e / ITGA5 antibody

CD49e / ITGA5 Mouse IgG1 JBS5 Purified Can, Hu C, F, IP
0.2 mg / €480.00
  Acris Antibodies GmbH

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