CD49f / ITGA6 antibody

Principal name

CD49f / ITGA6 antibody

Alternative names for CD49f / ITGA6 antibody

Integrin alpha-6, VLA-6, VLA6, CD49 antigen-like family member F

SwissProt ID

P23229 (Human), P26007 (Chick), Q61739 (Mouse)

Gene ID

3655 (ITGA6)

Available reactivities

Hu (Human), Can (Canine), Mky (Monkey), Ms (Mouse), Por (Porcine), Bov (Bovine), Eq (Equine), Fe (Feline), Rb (Rabbit), Sh (Sheep), Bab (Baboon), Rt (Rat), Hst (Hamster), Bt (Bat)

Available hosts

Rabbit, Rat, Mouse

Available applications

Enzyme Immunoassay (E), Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Functional assay (FN)

Background of CD49f / ITGA6 antibody

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. 
Function: Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. 
Cellular Location: Cell membrane; Single-pass type I membrane protein. 
Tissue Location: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).

General readings

1. Soligo, D. et al. (1989) Immunohistochemical reacitivy on bone marrow and tissues of anti-VLA antibodies in the platelet panel, in Leucocyte Typing IV:White Cell Differentiation Antigens. Edited by Knapp, W. et al. Oxford University Press p1029-1032.
2. Sonnenberg, A. et al. (1986) Development of mouse mammary gland: identification of stages in differentiation of luminal and myoepithelial cells using monoclonal antibodies and polyvalent antiserum against keratin. Histochem. Cytochem 34: 1037-1046.
3. Sonnenberg, A. et al . (1987) A complex platelet glycoprotein Ic and IIa indentified by a rat monoclonal antibody. J. Biol. Chem. 262: 10376-10383.
4. Helmer, M. et al. (1988) Multiple Very Late Antigen (VLA) Heterodimers on platelets. J. Biol. Chem. 263: 7660-
7665.
5. Galkowska, H. et al. (1996) Reactivity of antibodies directed against human antigens with surface markers on
canine leukocytes. Vet. Immunol. Immunpathol. 53: 329 - 334.
6. Sonnenberg, A. et al. (1988) Laminin receptor on platelets is the intergrin VLA-6. Nature. 336: 487 - 489.
7. Sonnenberg, A. et al. (1990) Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragments E8. J. Cell. Biol. 110: 2145 - 2155.
8. Yoshino, N. et al. (2000) Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of Cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp. Anim. 49 (2): 97-110
9. Sonneberg, A. et al. (1990) The alpha 6 beta 1 (VLA-6) and alpha 6 beta 4 protein complexes: tissue distribution and biochemical properties. J. Cell Sci. 96: 207 - 217.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD49f / ITGA6 antibody

Formalin-Fixed, Paraffin-Embedded Human Breast stained with ITGA6 antibody Cat.-No AP22798PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu E, P, WB
0.2 ml / €470.00
  Acris Antibodies GmbH

CD49f / ITGA6 antibody

Sample (20 ug of whole cell lysate). A: human ESC. 5% SDS PAGE. TA308910 diluted at 1:2000. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD49f / ITGA6 antibody

Staining of normal human peripheral blood cells with 0.25 ug of Rat IgG2a Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human/Mouse CD49f (Integrin alpha 6) Purified  (filled histogram) followed by Anti-Rat IgG PE .  Cells in the lymphocyte gate were used for analysis. Rat eBioGoH3 (GoH3) Purified Hu, Ms F, IP, P
50 µg / €120.00
  OriGene Technologies, Inc.

CD49f / ITGA6 (Isoform 2) antibody

Western blot analysis of anti-ITGA6 Antibody (isoform 2 S1064) (Cat.#TA324731) in 293 cell line lysates (35ug/lane). ITGA6(arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CD49f / ITGA6 antibody

Anti-ITGA6 / CD49f antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Can, Eq, Hst, Hu, Ms
50 µg / €379.00
  OriGene Technologies, Inc.

CD49f / ITGA6 antibody

Anti-ITGA6 / CD49f antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

CD49f / ITGA6 antibody

Anti-ITGA6 / CD49f antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Bt, Hu, Mky, Por
50 µg / €379.00
  OriGene Technologies, Inc.

CD49f / ITGA6 antibody

Anti-ITGA6 / CD49f antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

CD49f / ITGA6 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITGA6 (RC221990, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ITGA6. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD49f / ITGA6 antibody

CD49f / ITGA6 Rat IgG2a CLB-701 Purified Hu C, FN, ICC/IF
1 ml / €480.00
  Acris Antibodies GmbH

CD49f / ITGA6 antibody

CD49f / ITGA6 Rat IgG2a NKI-GoH3 Supernatant Can, Hu, Mky, Ms, Por C, F, ICC/IF, WB
1 ml / €400.00
  Acris Antibodies GmbH

CD49f / ITGA6 (6B Isoform specific) antibody

Immunostaining of Human ovarian carcinoma cells (cell line:OVCAR-3) Mouse IgG1 6B4 Purified Hu C, ICC/IF, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD49f / ITGA6 antibody

Staining of human peripheral blood lymphocytes with RAT ANTI HUMAN/MOUSE CD49f:BIOTIN Rat IgG2a NKI-GoH3 Biotin Can, Hu, Mky, Ms, Por F
0.1 mg / €420.00
  Acris Antibodies GmbH

CD49f / ITGA6 antibody

Staining of human peripheral blood lymphocytes with RAT ANTI HUMAN/MOUSE CD49f:BIOTIN Rat IgG2a NKI-GoH3 Biotin Can, Hu, Mky, Ms, Por F
25 µg / €220.00
  Acris Antibodies GmbH

CD49f / ITGA6 antibody

Staining of human peripheral blood lymphocytes with RAT ANTI HUMAN/MOUSE CD49f:FITC Rat IgG2a NKI-GoH3 FITC Can, Hu, Mky, Ms, Por, Sh F
0.1 mg / €390.00
  Acris Antibodies GmbH

CD49f / ITGA6 antibody

Staining of human peripheral blood lymphocytes with RAT ANTI HUMAN/MOUSE CD49f:FITC Rat IgG2a NKI-GoH3 FITC Can, Hu, Mky, Ms, Por F
25 µg / €190.00
  Acris Antibodies GmbH

CD49f / ITGA6 antibody

Staining of human peripheral blood lymphocytes with Rat Anti Human/Mouse CD49f Antibody Cat.-No SM038P Rat IgG2a NKI-GoH3 Purified Can, Hu, Mky, Ms, Por C, F, IP
0.2 mg / €430.00
  Acris Antibodies GmbH

CD49f / ITGA6 antibody

CD49f / ITGA6 Rat IgG2a NKI-GoH3 Purified Can, Hu, Mky, Ms, Por, Sh C, F, IP
0.1 mg / €270.00
  Acris Antibodies GmbH

CD49f / ITGA6 antibody

Staining of human peripheral blood lymphocytes with Rat Anti Human/Mouse CD49f Antibody Cat.-No SM038P Rat IgG2a NKI-GoH3 Purified Can, Hu, Mky, Ms, Por, Sh C, F, IP
25 µg / €180.00
  Acris Antibodies GmbH

CD49f / ITGA6 antibody

Staining of human peripheral blood lymphocytes with RAT ANTI HUMAN/MOUSE CD49f (SM038R). Rat IgG2a NKI-GoH3 PE Can, Hu, Mky, Ms, Por F
0.1 mg / €470.00
  Acris Antibodies GmbH

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