CD5 antibody

Principal name

CD5 antibody

Alternative names for CD5 antibody

CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5

SwissProt ID

F6PYA8, O73906 (Chick), P06127 (Human), P13379 (Mouse), P19238 (Bovin), P51882 (Rat), Q07452 (Sheep), Q9GMA0

Gene ID

12507 (Cd5), 54236, 921 (CD5), 280745, 395757

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human), Bov (Bovine), Gt (Goat), Sh (Sheep), Chk (Chicken), Por (Porcine), Chimp (Chimpanzee), Mky (Monkey), Eq (Equine), Can (Canine), Fe (Feline)

Available hosts

Mouse, Rat, Rabbit

Available applications

Flow Cytometry (F), Cytotoxicity Assay (CT), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Functional assay (FN), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Neutralisation (NEUT), ELISA (capture) (E(capture)), Luminex (LMNX)

Background of CD5 antibody

CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains.
The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.
Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative
disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some
autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of
CD5 expression in the expanded CD8+ human T cells.

General readings

1. Engleman EG, Warnke R, Fox RI, Dilley J, Benike CJ, Levy R: Studies of a human T lymphocyte antigen recognized by a monoclonal antibody. Proc Natl Acad Sci U S A. 1981 Mar;78(3):1791-5.
2. Shuster JJ, Falletta JM, Pullen DJ, Crist WM, Humphrey GB, Dowell BL, Wharam MD, Borowitz M: Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Blood. 1990 Jan 1;75(1):166-73.
3. McAlister MS, Davis B, Pfuhl M, Driscoll PC: NMR analysis of the N-terminal SRCR domain of human CD5: engineering of a glycoprotein for superior characteristics in NMR experiments. Protein Eng. 1998 Oct;11(10):847-53.
4. Gong JZ, Lagoo AS, Peters D, Horvatinovich J, Benz P, Buckley PJ: Value of CD23 determination by flow cytometry in differentiating mantle cell lymphoma from chronic lymphocytic leukemia/small lymphocytic lymphoma. Am J Clin Pathol. 2001 Dec;116(6):893-7.
Dunphy CH, Tang W: The value of CD64 expression in distinguishing acute myeloid leukemia with monocytic differentiation from other subtypes of acute myeloid leukemia: a flow cytometric analysis of 64 cases. Arch Pathol Lab Med. 2007 May;131(5):748-54.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD5 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-CD5 mouse monoclonal antibody. (Clone UMAB9, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB9 Purified Hu F, ICC/IF, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD5 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-CD5 mouse monoclonal antibody. (Clone UMAB9, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB9 Purified Hu F, ICC/IF, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD5 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-CD5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501335, Dilution 1:50) Mouse IgG1 OTI7A7 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD5 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-CD5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501376) Mouse IgG1 OTI2B8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD5 antibody

CD5 ELISA with 2G8 Capture (TA600467) and 9E9 Detection (TA700465) Antibodies. Substrate used: Recombinant Human CD5 (TP306494) Mouse IgG1 OTI2G8 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD5 antibody

CD5 ELISA with 6F7 Capture (TA600468) and 3A9 Detection (TA700468) Antibodies. Substrate used: Recombinant Human CD5 (TP306494) Mouse IgG1 OTI6F7 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD5 antibody

CD5 ELISA with 10H3 Capture (TA600464) and 5D4 Detection (TA700464) Antibodies. Substrate used: Recombinant Human CD5 (TP306494) Mouse IgG1 OTI5D4 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

CD5 antibody

CD5 ELISA with 3A9 Capture (TA600465) and 9E9 Detection (TA700465) Antibodies. Substrate used: Recombinant Human CD5 (TP306494) Mouse IgG1 OTI9E9 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

CD5 antibody

CD5 ELISA with 6F7 Capture (TA600468) and 10H3 Detection (TA700466) Antibodies. Substrate used: Recombinant Human CD5 (TP306494) Mouse IgG1 OTI10H3 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

CD5 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-CD5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802427) Mouse IgG1 OTI10F4 Purified Hu F, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD5 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 µm) stained with CD5 antibody (DB 027) shows positive immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliakova, MD and Lubomír Straka, MD, Ph. D. from Clinical Pathology. Presov, Ltd., Presov, Slovakia. Rabbit IgG A25-G Aff - Purified P
0.1 ml / €310.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD5 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 µm) stained with CD5 antibody (DB 027) shows positive immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliakova, MD and Lubomír Straka, MD, Ph. D. from Clinical Pathology. Presov, Ltd., Presov, Slovakia. Rabbit IgG A25-G Aff - Purified P
0.2 ml / €420.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD5 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 µm) stained with CD5 antibody (DB 027) shows positive immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliakova, MD and Lubomír Straka, MD, Ph. D. from Clinical Pathology. Presov, Ltd., Presov, Slovakia. Rabbit IgG A25-G Aff - Purified P
0.5 ml / €540.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD5 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 µm) stained with CD5 antibody (DB 027) shows positive immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliakova, MD and Lubomír Straka, MD, Ph. D. from Clinical Pathology. Presov, Ltd., Presov, Slovakia. Rabbit IgG A25-G Aff - Purified P
1 ml / €840.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD5 antibody

AM11112PU CD5 antibody staining of Human tonsil. Rabbit SP19 Supernatant Hu P
1 ml / €650.00
  Acris Antibodies GmbH

CD5 antibody

AM11112PU CD5 antibody staining of Human tonsil. Rabbit SP19 Supernatant Hu P

Regular Price: 0.2 ml / €200.00

Special Price: 0.2 ml / €140.00

  Acris Antibodies GmbH

CD5 antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with CD5 Antibody Cat.-No AM32836SU (Clone C5/473) at 1/200 dilution using peroxidase-conjugate and DAB chromogen. Note membrane staining. Mouse IgG1 C5/473 Supernatant Hu C, F, ICC/IF, IP, P, WB
1.0 ml / €360.00
  Acris Antibodies GmbH

CD5 antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with CD5 Antibody Cat.-No AM32836SU (Clone C5/473) at 1/200 dilution using peroxidase-conjugate and DAB chromogen. Note membrane staining. Mouse IgG1 C5/473 Supernatant Hu C, F, ICC/IF, IP, P, WB
0.5 ml / €290.00
  Acris Antibodies GmbH

CD5 antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with CD5 Antibody Cat.-No AM32836SU (Clone C5/473) at 1/200 dilution using peroxidase-conjugate and DAB chromogen. Note membrane staining. Mouse IgG1 C5/473 Supernatant Hu C, F, ICC/IF, IP, P, WB
0.1 ml / €150.00
  Acris Antibodies GmbH

CD5 antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with CD5 Antibody Cat.-No AM50190PU (Clone SPM546). Mouse IgG1 SPM546 Purified Hu F, ICC/IF, P
0.2 mg / €390.00
  Acris Antibodies GmbH

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