CD5 antibody
Principal name
CD5 antibody
Alternative names for CD5 antibody
CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5
SwissProt ID
F6PYA8, O73906 (Chick), P06127 (Human), P13379 (Mouse), P19238 (Bovin), P51882 (Rat), Q07452 (Sheep), Q9GMA0
Ncbi ID
NP_031676.3, NP_055022.2, NP_062168.1, NP_776324.1, NP_990252.1, 9823, 9606, NP_055022, NP_031676, ABM83003.1, NM_014207, NM_007650, NM_019295
Available reactivities
Available hosts
Available applications
Cytotoxicity Assay (CT), Flow Cytometry (F), Frozen Sections (C), Paraffin Sections (P), ELISA (capture) (E(capture)), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Functional assay (FN), Luminex (LMNX)
Background of CD5 antibody
CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains.
The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.
Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative
disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some
autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of
CD5 expression in the expanded CD8+ human T cells.
General readings
1. Freedman AS, Freeman G, Whitman J, Segil J, Daley J, Levine H, Nadler LM: Expression and regulation of CD5 on in vitro activated human B cells. Eur J Immunol. 1989 May;19(5):849-55.
Raman C.: CD5, an important regulator of lymphocyte selection and immune tolerance. Immunol Res. 2002;26(1-3):255-63.
2. Leukocyte Typing III., McMichael A. J. et al. (Eds.), Oxford University Press (1987).
3. Arrizabalaga P, Mirapeix E, Darnell A, Torras A, Revert L.: Cellular immunity analysis using monoclonal antibodies in human glomerulonephritis. Nephron. 1989;53(1):41-9.
3. Alberola-Ila J, Places L, Cantrell DA, Vives J, Lozano F.: Intracellular events involved in CD5-induced human T cell activation and proliferation. J Immunol. 1992 Mar 1;148(5):1287-93.
4. Guarne A, Bravo J, Calvo J, Lozano F, Vives J, Fita I.: Conformation of the hypervariable region L3 without the key proline residue. Protein Sci. 1996 Jan;5(1):167-9.








































































































































- Quick-Filters:
- Highly Validated (10)
Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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UM500009 | CD5 antibody |
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CD5 mouse monoclonal antibody, clone UMAB9 | |||||||
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Mouse | IgG1 | UMAB9 | Purified | Hu | F, ICC/IF, WB |
0.1 ml /
€468.00
|
OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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UM570009 | CD5 antibody |
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CD5 mouse monoclonal antibody, clone UMAB9 | |||||||
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Mouse | IgG1 | UMAB9 | Purified | Hu | F, ICC/IF, WB |
30 µl /
€120.00
|
OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA501335 | CD5 antibody |
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anti-CD5 mouse monoclonal antibody, clone OTI7A7 (formerly 7A7) | |||||||
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Mouse | IgG1 | OTI7A7 | Purified | Hu | F, ICC/IF, P, WB |
0.1 ml /
€350.00
|
OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA501376 | CD5 antibody |
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CD5 mouse monoclonal antibody, clone OTI2B8 (formerly 2B8) | |||||||
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Mouse | IgG1 | OTI2B8 | Purified | Hu | F, ICC/IF, P, WB |
0.1 ml /
€350.00
|
OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA600467 | CD5 antibody |
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Luminex and ELISA validated purified CD5 mouse monoclonal antibody clone (2G8, clone OTI2G8 (formerly 2G8) | |||||||
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Mouse | IgG1 | OTI2G8 | Purified | Hu | E, LMNX |
0.1 mg /
€350.00
|
OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA600468 | CD5 antibody |
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Luminex and ELISA validated purified CD5 mouse monoclonal antibody clone (6F7, clone OTI6F7 (formerly 6F7) | |||||||
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Mouse | IgG1 | OTI6F7 | Purified | Hu | E, LMNX |
0.1 mg /
€350.00
|
OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA700464 | CD5 antibody |
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Luminex and ELISA validated purified biotinylated CD5 mouse monoclonal antibody clone (5D4), clone OTI5D4 (formerly 5D4) | |||||||
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Mouse | IgG1 | OTI5D4 | Purified | Hu | E, LMNX |
50 µg /
€350.00
|
OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA700465 | CD5 antibody |
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Luminex and ELISA validated purified biotinylated CD5 mouse monoclonal antibody clone (9E9), clone OTI9E9 (formerly 9E9) | |||||||
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Mouse | IgG1 | OTI9E9 | Purified | Hu | E, LMNX |
50 µg /
€350.00
|
OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA700466 | CD5 antibody |
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Luminex and ELISA validated purified biotinylated CD5 mouse monoclonal antibody clone (10H3), clone OTI10H3 (formerly 10H3) | |||||||
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Mouse | IgG1 | OTI10H3 | Purified | Hu | E, LMNX |
50 µg /
€350.00
|
OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA802427 | CD5 antibody |
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CD5 mouse monoclonal antibody, clone OTI10F4 (formerly 10F4) | |||||||
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Mouse | IgG1 | OTI10F4 | Purified | Hu | F, P |
0.1 ml /
€350.00
|
OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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DB 027-0.1 | CD5 (C-term) antibody |
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Rabbit | IgG | A25-G | Aff - Purified | P |
0.1 ml /
€310.00
|
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DB Biotech, spol. s r.o. | |||||||
Acris recommends this product for Immunohistochemistry. |
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DB 027-0.2 | CD5 (C-term) antibody |
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Rabbit | IgG | A25-G | Aff - Purified | P |
0.2 ml /
€420.00
|
|
DB Biotech, spol. s r.o. | |||||||
Acris recommends this product for Immunohistochemistry. |
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DB 027-0.5 | CD5 (C-term) antibody |
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Rabbit | IgG | A25-G | Aff - Purified | P |
0.5 ml /
€540.00
|
|
DB Biotech, spol. s r.o. | |||||||
Acris recommends this product for Immunohistochemistry. |
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DB 027-1 | CD5 (C-term) antibody |
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Rabbit | IgG | A25-G | Aff - Purified | P |
1 ml /
€840.00
|
|
DB Biotech, spol. s r.o. | |||||||
Acris recommends this product for Immunohistochemistry. |
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AM50190PU-N | CD5 antibody |
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Mouse | IgG1 | SPM546 | Purified | Hu | F, ICC/IF, P |
0.2 mg /
€410.00
|
Acris Antibodies GmbH | |||||||
Acris recommends this product for Immunohistochemistry. |
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AM50190PU-S | CD5 antibody |
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Mouse | IgG1 | SPM546 | Purified | Hu | F, ICC/IF, P |
0.1 mg /
€320.00
|
Acris Antibodies GmbH | |||||||
Acris recommends this product for Immunohistochemistry. |
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AM50190PU-T | CD5 antibody |
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Mouse | IgG1 | SPM546 | Purified | Hu | F, ICC/IF, P |
20 µg /
€180.00
|
Acris Antibodies GmbH | |||||||
Acris recommends this product for Immunohistochemistry. |
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TA320284 | CD5 antibody |
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Rat Anti-Mouse CD5 Purified (100 ug) | |||||||
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Rat | 53-7.3 | Purified | Ms | F, IP, P |
0.1 mg /
€164.00
|
|
OriGene Technologies, Inc. | |||||||
TA320285 | CD5 antibody |
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Mouse Anti-Human CD5 Purified (100 ug) | |||||||
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Mouse | UCHT2 | Purified | Hu | F, P, WB |
0.1 mg /
€164.00
|
|
OriGene Technologies, Inc. | |||||||
TA327644 | CD5 antibody |
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Mouse Monoclonal CD5 Antibody | |||||||
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Mouse | IgG | 4C7 | Purified | Hu | P |
1 ml /
€860.00
|
OriGene Technologies, Inc. |