CD5 antibody

Principal name

CD5 antibody

Alternative names for CD5 antibody

CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5

SwissProt ID

F6PYA8, O73906 (Chick), P06127 (Human), P13379 (Mouse), P19238 (Bovin), P51882 (Rat), Q07452 (Sheep), Q9GMA0

Gene ID

12507 (Cd5), 921 (CD5), 54236, 280745, 395757

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Bov (Bovine), Gt (Goat), Sh (Sheep), Chk (Chicken), Por (Porcine), Eq (Equine), Mky (Monkey), GP (Guinea Pig), Op (Opossum), Prim (Primate), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Rat

Available applications

Cytotoxicity Assay (CT), Flow Cytometry (F), Frozen Sections (C), Paraffin Sections (P), ELISA (capture) (E(capture)), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Functional assay (FN), Luminex (LMNX)

Background of CD5 antibody

CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains.
The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.
Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative
disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some
autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of
CD5 expression in the expanded CD8+ human T cells.

General readings

1. Freedman AS, Freeman G, Whitman J, Segil J, Daley J, Levine H, Nadler LM: Expression and regulation of CD5 on in vitro activated human B cells. Eur J Immunol. 1989 May;19(5):849-55.
Raman C.: CD5, an important regulator of lymphocyte selection and immune tolerance. Immunol Res. 2002;26(1-3):255-63.
2. Leukocyte Typing III., McMichael A. J. et al. (Eds.), Oxford University Press (1987).
3. Arrizabalaga P, Mirapeix E, Darnell A, Torras A, Revert L.: Cellular immunity analysis using monoclonal antibodies in human glomerulonephritis. Nephron. 1989;53(1):41-9.
3. Alberola-Ila J, Places L, Cantrell DA, Vives J, Lozano F.: Intracellular events involved in CD5-induced human T cell activation and proliferation. J Immunol. 1992 Mar 1;148(5):1287-93.
4. Guarne A, Bravo J, Calvo J, Lozano F, Vives J, Fita I.: Conformation of the hypervariable region L3 without the key proline residue. Protein Sci. 1996 Jan;5(1):167-9.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD5 antibody

  CD5 mouse monoclonal antibody, clone UMAB9  
Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-CD5 mouse monoclonal antibody. (Clone UMAB9, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB9 Purified Hu F, ICC/IF, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD5 antibody

  CD5 mouse monoclonal antibody, clone UMAB9  
Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-CD5 mouse monoclonal antibody. (Clone UMAB9, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB9 Purified Hu F, ICC/IF, WB
30 µl / €120.00
  OriGene Technologies, Inc.

UltraMAB

CD5 antibody

  anti-CD5 mouse monoclonal antibody, clone OTI7A7 (formerly 7A7)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-CD5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501335, Dilution 1:50) Mouse IgG1 OTI7A7 Purified Hu F, ICC/IF, P, WB
0.1 ml / €350.00
  OriGene Technologies, Inc.

TrueMAB

CD5 antibody

  CD5 mouse monoclonal antibody, clone OTI2B8 (formerly 2B8)  
Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-CD5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501376) Mouse IgG1 OTI2B8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €350.00
  OriGene Technologies, Inc.

TrueMAB

CD5 antibody

  Luminex and ELISA validated purified CD5 mouse monoclonal antibody clone (2G8, clone OTI2G8 (formerly 2G8)  
CD5 ELISA with 2G8 Capture (TA600467) and 9E9 Detection (TA700465) Antibodies. Substrate used: Recombinant Human CD5 (TP306494) Mouse IgG1 OTI2G8 Purified Hu E, LMNX
0.1 mg / €350.00
  OriGene Technologies, Inc.

CD5 antibody

  Luminex and ELISA validated purified CD5 mouse monoclonal antibody clone (6F7, clone OTI6F7 (formerly 6F7)  
CD5 ELISA with 6F7 Capture (TA600468) and 3A9 Detection (TA700468) Antibodies. Substrate used: Recombinant Human CD5 (TP306494) Mouse IgG1 OTI6F7 Purified Hu E, LMNX
0.1 mg / €350.00
  OriGene Technologies, Inc.

CD5 antibody

  Luminex and ELISA validated purified biotinylated CD5 mouse monoclonal antibody clone (5D4), clone OTI5D4 (formerly 5D4)  
CD5 ELISA with 10H3 Capture (TA600464) and 5D4 Detection (TA700464) Antibodies. Substrate used: Recombinant Human CD5 (TP306494) Mouse IgG1 OTI5D4 Purified Hu E, LMNX
50 µg / €350.00
  OriGene Technologies, Inc.

CD5 antibody

  Luminex and ELISA validated purified biotinylated CD5 mouse monoclonal antibody clone (9E9), clone OTI9E9 (formerly 9E9)  
CD5 ELISA with 3A9 Capture (TA600465) and 9E9 Detection (TA700465) Antibodies. Substrate used: Recombinant Human CD5 (TP306494) Mouse IgG1 OTI9E9 Purified Hu E, LMNX
50 µg / €350.00
  OriGene Technologies, Inc.

CD5 antibody

  Luminex and ELISA validated purified biotinylated CD5 mouse monoclonal antibody clone (10H3), clone OTI10H3 (formerly 10H3)  
CD5 ELISA with 6F7 Capture (TA600468) and 10H3 Detection (TA700466) Antibodies. Substrate used: Recombinant Human CD5 (TP306494) Mouse IgG1 OTI10H3 Purified Hu E, LMNX
50 µg / €350.00
  OriGene Technologies, Inc.

CD5 antibody

  CD5 mouse monoclonal antibody, clone OTI10F4 (formerly 10F4)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-CD5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802427) Mouse IgG1 OTI10F4 Purified Hu F, P
0.1 ml / €350.00
  OriGene Technologies, Inc.

TrueMAB

CD5 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 µm) stained with CD5 antibody (DB 027) shows positive immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliakova, MD and Lubomír Straka, MD, Ph. D. from Clinical Pathology. Presov, Ltd., Presov, Slovakia. Rabbit IgG A25-G Aff - Purified P
0.1 ml / €310.00
  DB Biotech, spol. s r.o.

CD5 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 µm) stained with CD5 antibody (DB 027) shows positive immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliakova, MD and Lubomír Straka, MD, Ph. D. from Clinical Pathology. Presov, Ltd., Presov, Slovakia. Rabbit IgG A25-G Aff - Purified P
0.2 ml / €420.00
  DB Biotech, spol. s r.o.

CD5 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 µm) stained with CD5 antibody (DB 027) shows positive immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliakova, MD and Lubomír Straka, MD, Ph. D. from Clinical Pathology. Presov, Ltd., Presov, Slovakia. Rabbit IgG A25-G Aff - Purified P
0.5 ml / €540.00
  DB Biotech, spol. s r.o.

CD5 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 µm) stained with CD5 antibody (DB 027) shows positive immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliakova, MD and Lubomír Straka, MD, Ph. D. from Clinical Pathology. Presov, Ltd., Presov, Slovakia. Rabbit IgG A25-G Aff - Purified P
1 ml / €840.00
  DB Biotech, spol. s r.o.

CD5 antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with CD5 Antibody Cat.-No AM50190PU (Clone SPM546). Mouse IgG1 SPM546 Purified Hu F, ICC/IF, P
0.2 mg / €410.00
  Acris Antibodies GmbH

CD5 antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with CD5 Antibody Cat.-No AM50190PU (Clone SPM546). Mouse IgG1 SPM546 Purified Hu F, ICC/IF, P
0.1 mg / €320.00
  Acris Antibodies GmbH

CD5 antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with CD5 Antibody Cat.-No AM50190PU (Clone SPM546). Mouse IgG1 SPM546 Purified Hu F, ICC/IF, P
20 µg / €180.00
  Acris Antibodies GmbH

CD5 antibody

  Rat Anti-Mouse CD5 Purified (100 ug)  
Staining of mouse splenocytes with Anti-Mouse CD5 FITC (left) and PE (right).  Appropriate isotype controls were used  (open histogram).  Total viable cells were used for analysis. Rat 53-7.3 Purified Ms F, IP, P
0.1 mg / €164.00
  OriGene Technologies, Inc.

CD5 antibody

  Mouse Anti-Human CD5 Purified (100 ug)  
Staining of normal human peripheral blood cells with Anti-Human CD5 FITC.  Appropriate isotype controls were used (open histogram).  Cells in the lymphocyte population were used for analysis. Mouse UCHT2 Purified Hu F, P, WB
0.1 mg / €164.00
  OriGene Technologies, Inc.

CD5 antibody

  Mouse Monoclonal CD5 Antibody  
Immunohistochemistry staining of Paraffin Tonsil tissue by CD5 antibody (dilution: 1:10 - 1:50; visualization of staining: Membranous) Mouse IgG 4C7 Purified Hu P
1 ml / €860.00
  OriGene Technologies, Inc.

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