CD51 / ITGAV antibody

Principal name

CD51 / ITGAV antibody

Alternative names for CD51 / ITGAV antibody

Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha

SwissProt ID

P06756 (Human), P26008 (Chick), P43406 (Mouse), P80746 (Bovin)

Gene ID

3685 (ITGAV), 16410 (Itgav)

Available reactivities

Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Gt (Goat), Rb (Rabbit), Sh (Sheep)

Available hosts

Mouse, Rat, Rabbit

Available applications

Immunoprecipitation (IP), Flow Cytometry (F), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Frozen Sections (C), Functional assay (FN), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of CD51 / ITGAV antibody

Integrins are a superfamily of αβ heterodimeric cell-surface adhesion receptors found in many species. They are expressed on a variety of cells and mediate numerous physiological processes, including inflammation, migration, adhesion and proliferation. The β3 family consist of 2 members: αIIbβ3 and αvβ3, which mediate cell-cell and cell-ECM interactions and are important for cellular migration, regulation of gene expression, cell survival, adhesion and differentiation. All processes which are involved in tissue development, angiogenesis and thrombosis. Each subunit consist of an extracellular domain, a single transmembrane segment and a cytoplasmic tail. They connect to the actin cytoskeleton via adaptor proteins that bind theircytoplasmic tails. Cell matrix adhesions also act as signaling units by their capacity to organize the actin cytoskeleton and to accumulate various signaling intermediates. Integrin αvβ3 was originally identified as the vitronectin receptor. Nevertheless, other ligands include fibrinogen, fibronectin, laminin, thrombospondin, Von Willebrand factor, tenascin, osteopontin and several forms of collagen. The interactions of integrin αvβ3 to those ligands is mediated by the RGD (Arg-Gly-Asp) sequence motif present in these proteins. Deregulation of β3 integrins is involved in e.g. autoimmune diseases, cardiovascular disorders, transplant rejection and tumorigenesis. In contribution to the latter, integrin αvβ3 contribute by supporting growth of small (tumor) blood vessels thereby potentiating the metastatic potential. Overexpression of integrin αvβ3 has been demonstrated in various tumors and activated endothelium.

General readings

1. Horton MA, Lewis D, McNulty K, Pringle JA, Chambers TJ. Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. Cancer Res. 1985;45:5563-9. 
2. Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, et al. Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest. 2005;115:339-47.  
3. Adams JC, Watt FM. Expression of β1, β3, β4, and β5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes. J Cell Biol. 1991;115:829-41.
4. Nesbitt S, Nesbit A, Helfrich M, Horton M. Biochemical characterization of human osteoclast integrins. Osteoclasts express αvβ3, α2β1, and αvβ1 integrins. J Biol Chem. 1993;268:16737-45. 
5. Davies J, Warwick J, Totty N, Philip R, Helfrich M, Horton M. The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol. 1989;109:1817-26.
6. Janes SM, Watt FM. Switch from αvβ5 to αvβ6 integrin expression protects squamous cell carcinomas from anoikis. J Cell Biol. 2004;166:419-31. 
7. Pasqualini R, Bodorova J, Ye S, Hemler ME. A study of the structure, function and distribution of β5 integrins using novel anti-β5 monoclonal antibodies. J Cell Sci. 1993;105:101-11.
8. Andreesen R, Brugger W, Scheibenbogen C, Kreutz M, Leser H, Rehm A, et al. Surface phenotype analysis of human monocyte to macrophage maturation. J Leukoc Biol. 1990;47:490-7.
9. Wong DA, Springer TA. Adhesion structure subpanels 7 and 8, β3, β4, β7 integrins and novel functional antigens: CD51, CD61, CD103, and CD104. In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al, editors. Leukocyte Typing V: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1995. p. 1655-9. 
10. Gravelle S, Barnes R, Hawdon N, Shewchuk L, Eibl J, Lam JS, et al. Up-regulation of integrin expression in lung adenocarcinoma cells caused by bacterial infection: in vitro study. Innate Immun. 2010;16:14-26.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD51/CD61 Complex antibody

CD51/CD61 Complex Mouse IgG1 23C6 Purified Chk, Hu F, IP
0.2 mg / €490.00
  Acris Antibodies GmbH

CD51/CD61 Complex antibody

CD51/CD61 Complex Mouse IgG1 23C6 Purified Chk, Hu F, IP
0.1 mg / €270.00
  Acris Antibodies GmbH

CD51/CD61 Complex antibody

CD51/CD61 Complex Mouse IgG1 23C6 Purified Chk, Hu F, IP
25 µg / €180.00
  Acris Antibodies GmbH

CD51 / ITGAV antibody

  Rabbit polyclonal ITGAV (heavy chain, Cleaved-Lys889) antibody  
Western blot analysis of extracts from A549 cells, treated with etoposide (25uM, 1hour), using ITGAV (heavy chain, Cleaved-Lys889) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

  Mouse Anti-Human CD51/CD61 (Integrin alpha v beta 3) Purified (100 ug)  
Staining of platelets with 0.5 ug of Mouse IgG1 Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human CD51/CD61 (Integrin alpha/beta 3) Purified followed by Anti-Mouse IgG FITC (filled histogram). Mouse 23C6 Purified Hu F, P
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

  Rat Anti-Mouse CD51 (Integrin alpha V) Purified (50 ug)  
Staining of C57Bl/6 bone marrow cells with 1 ug of Rat IgG1 Isotype Control Purified (open histogram) or 1 ug of Anti-Mouse CD51 (Integrin alpha V) Purified (filled histogram) followed by Anti-Rat IgG PE .  Cells in the large scatter population were used for analysis. Rat RMV-7 Purified Ms F, IP, WB
50 µg / €120.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

  Anti-ITGAV Rabbit Polyclonal Antibody  
Predicted band size: 115 kDa . Positive control: A549 cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

  ITGAV Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using ITGAV antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

  Rabbit Polyclonal Anti-ITGAV Antibody  
WB Suggested Anti-ITGAV Antibody; Titration: 1.0 ug/ml; Positive Control: PANC1 Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

  Rabbit Polyclonal Anti-Integrin aV Antibody  
Western blot analysis of Integrin alpha-V expression in HeLa cells Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

  Rat Monoclonal anti-CD51 Antibody  
C57BL/6 mouse bone marrow cells were stained with CD51 (clone RMV-7) PE (filled histogram) or Rat IgG1, kappa; PE isotype control (open histogram). Data shown was gated on myeloid  cell population. Rat RMV-7 Purified Ms F, IP
0.5 mg / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

  Mouse Monoclonal anti-CD51 Antibody  
MDA-MB231 breast cancer cell line was stained with anti-human CD51, detected with anti-mouse DyLighttrade; 649, and nuclear counterstained with DAPI. Images were acquired with a TE300 fluorescence microscope with a 20x objective. Data provided by: Er Liu and John Nolan, La Jolla Bioengineering Institute Mouse NKI-M9 Purified Hu E, F, IP, P
0.1 mg / €248.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

  Rat monoclonal Anti-Integrin aVb6 Clone AvB6 53a.2  
CD51 / ITGAV Rat IgG2a AvB6 53a.2 Purified Hu F, ICC/IF
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

  Rat monoclonal Anti-Integrin aVß6 Clone Avß6 62ow.17  
CD51 / ITGAV Rat IgG1 Avß6 62ow.17 Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

  Rat monoclonal Anti-Integrin aVb6 Clone 7k  
CD51 / ITGAV Rat IgG2a 7k Purified Hu E, F, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

  Rabbit Polyclonal Integrin alpha V Antibody  
ELISA: Integrin alpha V Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

CD51 / ITGAV Rat IgG1 RMV-7 Low Endotoxin Ms F, FN, IP
0.5 mg / €540.00
  Acris Antibodies GmbH

CD51 / ITGAV antibody

CD51 / ITGAV Rat IgG1 RMV-7 Purified Ms C, F, IP
0.25 mg / €390.00
  Acris Antibodies GmbH

CD51 / ITGAV antibody

CD51 / ITGAV Rat IgG1 RMV-7 Purified Ms C, F, IP
0.1 mg / €240.00
  Acris Antibodies GmbH

CD51 / ITGAV antibody

CD51 / ITGAV Rat IgG1 RMV-7 Purified Ms C, F, IP
25 µg / €170.00
  Acris Antibodies GmbH

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