CD51 / ITGAV antibody

Principal name

CD51 / ITGAV antibody

Alternative names for CD51 / ITGAV antibody

Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha

SwissProt ID

P06756 (Human), P26008 (Chick), P43406 (Mouse), P80746 (Bovin)

Gene ID

3685 (ITGAV), 16410

Available reactivities

Chk (Chicken), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Por (Porcine), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Gt (Goat), Sh (Sheep)

Available hosts

Mouse, Rat, Rabbit

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Neutralisation (NEUT), Paraffin Sections (P), Functional assay (FN)

Background of CD51 / ITGAV antibody

Integrins are a superfamily of αβ heterodimeric cell-surface adhesion receptors found in many species. They are expressed on a variety of cells and mediate numerous physiological processes, including inflammation, migration, adhesion and proliferation. The β3 family consist of 2 members: αIIbβ3 and αvβ3, which mediate cell-cell and cell-ECM interactions and are important for cellular migration, regulation of gene expression, cell survival, adhesion and differentiation. All processes which are involved in tissue development, angiogenesis and thrombosis. Each subunit consist of an extracellular domain, a single transmembrane segment and a cytoplasmic tail. They connect to the actin cytoskeleton via adaptor proteins that bind theircytoplasmic tails. Cell matrix adhesions also act as signaling units by their capacity to organize the actin cytoskeleton and to accumulate various signaling intermediates. Integrin αvβ3 was originally identified as the vitronectin receptor. Nevertheless, other ligands include fibrinogen, fibronectin, laminin, thrombospondin, Von Willebrand factor, tenascin, osteopontin and several forms of collagen. The interactions of integrin αvβ3 to those ligands is mediated by the RGD (Arg-Gly-Asp) sequence motif present in these proteins. Deregulation of β3 integrins is involved in e.g. autoimmune diseases, cardiovascular disorders, transplant rejection and tumorigenesis. In contribution to the latter, integrin αvβ3 contribute by supporting growth of small (tumor) blood vessels thereby potentiating the metastatic potential. Overexpression of integrin αvβ3 has been demonstrated in various tumors and activated endothelium.

General readings

General / background references:Rajaraman R Avian integrin alpha v subunit associates with multiple beta subunits and shows tissue-specific variation in its association. Exp Cell Res 205:25-31 (1993). PubMed PMID: 7681008
Chan BM et al. Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains. Cell 68:1051-60 (1992). PubMed PMID: 1547502
Bossy B & Reichardt LF Chick integrin alpha V subunit molecular analysis reveals high conservation of structural domains and association with multiple beta subunits in embryo fibroblasts. Biochemistry 29:10191-8 (1990). PubMed PMID: 1703004

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD51/CD61 Complex antibody

CD51/CD61 Complex Mouse IgG1 23C6 Purified Chk, Hu F, IP
0.2 mg / €490.00
  Acris Antibodies GmbH

CD51/CD61 Complex antibody

CD51/CD61 Complex Mouse IgG1 23C6 Purified Chk, Hu F, IP
0.1 mg / €270.00
  Acris Antibodies GmbH

CD51/CD61 Complex antibody

CD51/CD61 Complex Mouse IgG1 23C6 Purified Chk, Hu F, IP
25 µg / €180.00
  Acris Antibodies GmbH

CD51/CD61 Complex antibody

CD51/CD61 Complex Mouse IgG1 23C6 Purified Hu C, F, IP, NEUT, P
0.1 mg / €360.00
  Novus Biologicals Inc.

CD51/CD61 Complex antibody

Human melanoma cell line M21 stained with 23C6 FITC Mouse IgG1 23C6 FITC Chk, Hu, Rb C, F, ICC/IF, IP, NEUT, P
100 Tests / €290.00
  Novus Biologicals Inc.

CD51/CD61 Complex antibody

Human melanoma cell line M21 stained with biotinylated 23C6, followed by Sav-PE Mouse IgG1 23C6 Biotin Chk, Hu, Rb C, F, ICC/IF, IP, P
0.1 mg / €290.00
  Novus Biologicals Inc.

CD51 / ITGAV antibody

Western blot analysis of extracts from A549 cells, treated with etoposide (25uM, 1hour), using ITGAV (heavy chain, Cleaved-Lys889) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

Staining of platelets with 0.5 ug of Mouse IgG1 Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human CD51/CD61 (Integrin alpha/beta 3) Purified followed by Anti-Mouse IgG FITC (filled histogram). Mouse 23C6 Purified Hu F, P
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

Staining of C57Bl/6 bone marrow cells with 1 ug of Rat IgG1 Isotype Control Purified (open histogram) or 1 ug of Anti-Mouse CD51 (Integrin alpha V) Purified (filled histogram) followed by Anti-Rat IgG PE .  Cells in the large scatter population were used for analysis. Rat RMV-7 Purified Ms F, IP, WB
50 µg / €120.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

Predicted band size: 115 kDa . Positive control: A549 cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

Western blot analysis of extracts of various cell lines, using ITGAV antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

WB Suggested Anti-ITGAV Antibody; Titration: 1.0 ug/ml; Positive Control: PANC1 Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

Western blot analysis of Integrin alpha-V expression in HeLa cells Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

ELISA: Integrin alpha V Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD51 / ITGAV antibody

CD51 / ITGAV Rat IgG1 RMV-7 Low Endotoxin Ms F, FN, IP
0.5 mg / €540.00
  Acris Antibodies GmbH

CD51 / ITGAV antibody

CD51 / ITGAV Rat IgG1 RMV-7 Purified Ms C, F, IP
0.25 mg / €390.00
  Acris Antibodies GmbH

CD51 / ITGAV antibody

CD51 / ITGAV Rat IgG1 RMV-7 Purified Ms C, F, IP
0.1 mg / €240.00
  Acris Antibodies GmbH

CD51 / ITGAV antibody

CD51 / ITGAV Rat IgG1 RMV-7 Purified Ms C, F, IP
25 µg / €170.00
  Acris Antibodies GmbH

CD51 / ITGAV antibody

CD51 / ITGAV Rat IgG1 RMV-7 PE Ms F
100 Tests / €530.00
  Acris Antibodies GmbH

CD51 / ITGAV antibody

CD51 / ITGAV Mouse IgG1 13C2 FITC Hu F
100 Tests / €280.00
  Acris Antibodies GmbH

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