CD53 antibody

Principal name

CD53 antibody

Alternative names for CD53 antibody

Cell surface glycoprotein CD53, Tetraspanin-25, MOX44, TSPAN25, Leukocyte surface antigen CD53

SwissProt ID

P19397 (Human), P24485 (Rat), Q58DM3 (Bovin), Q61451 (Mouse)

Gene ID

963 (CD53), 12508 (Cd53), 24251

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rat, Rabbit

Available applications

Frozen Sections (C), Functional assay (FN), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of CD53 antibody

CD53 is a member of the tetraspan family of molecules, and is expressed by all leucocytes, but is absent from red cells and platelets. Most of the tetraspan family of molecules are cell surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2 generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. The antibody reacts with CD53 antigen, a glycoprotein of 32-40 kDa belonging to the tetraspans family (TM4SF). CD53 antigen is exclusivelly expressed on leucocytes (not present on platelets, red blood cells and non-hematopoietic cells). CD53 is important for signal transduction. CD53 cross-linking promotes activation of human B cells and rat macrophages.

General readings

Angelisova P, Vlcek C, Stefanova I, Lipoldova M, Horejsi V.: The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens. Immunogenetics. 1990;32(4):281-5.
Olweus J, Lund-Johansen F, Horejsi V.: CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells. J Immunol. 1993 Jul 15;151(2):707-16.
Mollinedo F, Martín-Martín B, Gajate C, Lazo PA: Physiological activation of human neutrophils down-regulates CD53 cell surface antigen. J Leukoc Biol. 1998 Jun;63(6):699-706.
Puls KL, Hogquist KA, Reilly N, Wright MD: CD53, a thymocyte selection marker whose induction requires a lower affinity TCR-MHC interaction than CD69, but is up-regulated with slower kinetics. Int Immunol. 2002 Mar;14(3):249-58.
Kim TR, Yoon JH, Kim YC, Yook YH, Kim IG, Kim YS, Lee H, Paik SG: LPS-induced CD53 expression: a protection mechanism against oxidative and radiation stress. Mol Cells. 2004 Feb 29;17(1):125-31.
Yunta M, Lazo PA: Apoptosis protection and survival signal by the CD53 tetraspanin antigen. Oncogene. 2003 Feb 27;22 (8):1219-24.
Yunta M, Rodriguez-Barbero A, Arevalo MA, Lopez-Novoa JM, Lazo PA: Induction of DNA synthesis by ligation of the CD53 tetraspanin antigen in primary cultures of mesangial cells. Kidney Int. 2003 Feb;63(2):534-42.
Bazil V, Stefanova I, Hilgert I, Kristofova H, Vanek S, Bukovsky A, Horejsi V.: Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102. Folia Biol (Praha). 1989;35(5):289-97.
Leukocyte Typing IV., Knapp W. et al. (Eds.), Oxford University Press (1989).
Rasmussen AM, Blomhoff HK, Stokke T, Horejsi V, Smeland EB.: Cross-linking of CD53 promotes activation of resting human B lymphocytes. J Immunol. 1994 Dec 1;153(11):4997-5007.
Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).
Szollosi J, Horejsi V, Bene L, Angelisova P, Damjanovich S.: Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. J Immunol. 1996 Oct 1;157 (7):2939-46.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD53 antibody

CD53 Mouse IgG1 OX-44 Purified Rt C, F, IP, P
0.25 mg / €420.00
  Acris Antibodies GmbH

CD53 antibody

CD53 Mouse IgG1 OX-44 Purified Rt C, F, IP, P
0.1 mg / €260.00
  Acris Antibodies GmbH

CD53 antibody

CD53 Mouse IgG1 MEM-53 Azide Free Hu C, F, FN, IP, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

CD53 antibody

Staining of human peripheral blood monocytes with MOUSE ANTI HUMAN CD53:FITC (SM1137F). Mouse IgG1 MEM-53 FITC Hu F
100 Tests / €390.00
  Acris Antibodies GmbH

CD53 antibody

CD53 Mouse IgG1 MEM-53 Low Endotoxin Hu C, F, FN, IP, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

CD53 antibody

Spleen, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 MEM-53 Purified Hu C, F, IP, P, WB
0.2 mg / €430.00
  Acris Antibodies GmbH

CD53 antibody

CD53 Mouse IgG1 MEM-53 Purified Hu C, F, FN, IP, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

CD53 antibody

CD53 Mouse IgG1 MEM-53 PE Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD53 antibody

Western Blot analysis of CD53 expression in transfected 293T cell line (H00000963-T01) by CD53 MaxPab polyclonal antibody.

Lane 1: CD53 transfected lysate(24.09 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

CD53 antibody

CD53 Mouse IgG1 MEM-53 Hu C, F, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CD53 antibody

CD53 Mouse IgG1 MEM-53 Hu F
100 reaction / €390.00
  Abnova Taiwan Corp.

CD53 antibody

CD53 Mouse IgG1 MEM-53 Hu F
100 reaction / €390.00
  Abnova Taiwan Corp.

CD53 antibody

Flow cytometric analysis of human peripheral blood monocytes using Anti-CD53 Antibody-FITC labled. Mouse IgG2a FITC Hu F, ICC/IF
50 Assays / €250.00
  Cohesion Biosciences Ltd.

CD53 antibody

Flow cytometric analysis of human peripheral blood monocytes using Anti-CD53 Antibody-FITC labled. Mouse IgG2a FITC Hu F, ICC/IF
100 Assays / €330.00
  Cohesion Biosciences Ltd.

CD53 antibody

Flow cytometric analysis of human peripheral blood monocytes using Anti-CD53 Antibody-PE labled. Mouse IgG2a PE Hu F, ICC/IF
50 Assays / €280.00
  Cohesion Biosciences Ltd.

CD53 antibody

Flow cytometric analysis of human peripheral blood monocytes using Anti-CD53 Antibody-PE labled. Mouse IgG2a PE Hu F, ICC/IF
100 Assays / €420.00
  Cohesion Biosciences Ltd.

CD53 antibody

Flow cytometric analysis of human peripheral blood monocytes using Anti-CD53 Antibody; followed by anti-mouse IgG PE. Mouse IgG2a Aff - Purified Hu F, ICC/IF
50 µl / €230.00
  Cohesion Biosciences Ltd.

CD53 antibody

Flow cytometric analysis of human peripheral blood monocytes using Anti-CD53 Antibody; followed by anti-mouse IgG PE. Mouse IgG2a Aff - Purified Hu F, ICC/IF
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CD53 antibody

Flow cytometric analysis of human peripheral blood monocytes using Anti-CD53 Antibody; followed by anti-mouse IgG PE. Mouse IgG2a Aff - Purified Hu F, ICC/IF
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CD53 antibody

CD53 Rat IgM OX-80 Supernatant Ms F
1 ml / €340.00
  Novus Biologicals Inc.

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