CD56 antibody

Principal name

CD56 antibody

Alternative names for CD56 antibody

NCAM-1, N-CAM-1, NCAM, Neural cell adhesion molecule 1

SwissProt ID

P13590 (Chick), P13591 (Human), P13595 (Mouse), P13596 (Rat), P31836 (Bovin)

Gene ID

4684 (NCAM1), 17967 (Ncam1), 24586

Available reactivities

Ms (Mouse), Hu (Human), Prim (Primate), Rt (Rat), Por (Porcine), Mky (Monkey), Bov (Bovine), Ze (Zebrafish), Can (Canine)

Available hosts

Rat, Mouse, Rabbit

Available applications

Immunoprecipitation (IP), Functional assay (FN), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Background of CD56 antibody

NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins. 
NCAM can be found in central and peripheral nerve cells, neuroendocrine tissues and at the surface of NK-cells. Also, NCAM is present in malignancies derived from these tissues and cells.

General readings

1. Lanier LL, Chang C, Azuma M, Ruitenberg JJ, Hemperly JJ, Phillips JH: Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule
(N-CAM/CD56). J Immunol. 1991 Jun 15;146(12):4421-6.
Jakovcevski I, Mo Z, Zecevic N: Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain. Neuroscience. 2007 Oct 26;149(2):328-37.
2. Ohishi Y, Kaku T, Oya M, Kobayashi H, Wake N, Tsuneyoshi M: CD56 expression in ovarian granulosa cell tumors, and its diagnostic utility and pitfalls. Gynecol Oncol. 2007 Oct;107(1):30-8.
3. McCluggage WG, McKenna M, McBride HA: CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors. Int J Gynecol Pathol. 2007 Jul;26(3):322-7.
4. Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).
Leukocyte Typing VII., Mason D. et al. (Eds.), Oxford University Press (2002).
5. Brdicka T, Imrich M, Angelisová P, Brdicková N, Horváth O, Spicka J, Hilgert I, Lusková P, Dráber P, Novák P, Engels N, Wienands J, Simeoni L, Osterreicher J, Aguado E, Malissen M, Schraven B, Horejsí V: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J Exp Med. 2002 Dec 16;196(12):1617-26.
6. Olsen I, Tollefsen S, Aagaard C, Reitan LJ, Bannantine JP, Andersen P, Sollid LM, Lundin KE: Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients.
7. Drbal K, Moertelmaier M, Holzhauser C, Muhammad A, Fuertbauer E, Howorka S, Hinterberger M, Stockinger H, Schütz GJ: Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement. Int Immunol. 2007 May;19(5):675-84.
8. Brdicková N, Brdicka T, Angelisová P, Horváth O, Spicka J, Hilgert I, Paces J, Simeoni L, Kliche S, Merten C, Schraven B, Horejsí V: LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. J Exp Med. 2003 Nov 17;198(10):1453-62.
9. Lin CW, Liu TY, Chen SU, Wang KT, Medeiros LJ, Hsu SM: CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features. Blood. 2005 Nov 15;106(10):3567-74.
10. Yates J, Rovis F, Mitchell P, Afzali B, Tsang JY, Garin M, Lechler RI, Lombardi G, Garden OA: The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro. Int Immunol. 2007 Jun;19(6):785-99.

  1. Quick-Filters:
  2. Highly Validated (11)

Items 1 to 20 of 118 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD56 (transcript variant 2) antibody

Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum using anti-NCAM1 mouse monoclonal antibody. (UM500067; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB83 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD56 (transcript variant 2) antibody

Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum using anti-NCAM1 mouse monoclonal antibody. (UM500067; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB83 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD56 antibody

Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum using anti-NCAM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800084)(1:200) Mouse IgG2b UMAB192 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD56 (transcript variant 2) antibody

Immunohistochemical staining of paraffin-embedded Human embryonic brain cortex tissue using anti-NCAM1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 110C for 10 min, UM800086)(1:400) Mouse IgG1 UMAB194 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD56 (transcript variant 2) antibody

Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum using anti-NCAM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800084)(1:200) Mouse IgG2b UMAB192 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD56 (transcript variant 2) antibody

Immunohistochemical staining of paraffin-embedded Human embryonic brain cortex tissue using anti-NCAM1 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 110C for 10 min, UM800086)(1:400) Mouse IgG1 UMAB194 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD56 antibody

Immunohistochemical staining of paraffin-embedded Human adult brain tissue using anti-NCAM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA804951) Mouse IgG1 OTI1A3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD56 antibody

Immunohistochemical staining of paraffin-embedded Human adult brain tissue using anti-NCAM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA804952) Mouse IgG2a OTI1C7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD56 antibody

Immunohistochemical staining of paraffin-embedded Human adult brain tissue using anti-NCAM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA804954) Mouse IgG1 OTI2A2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD56 antibody

Immunohistochemical staining of paraffin-embedded Human adult brain tissue using anti-NCAM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA805182) Mouse IgG1 OTI3H2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD56 antibody

Immunohistochemical staining of paraffin-embedded Human adult heart tissue using anti-NCAM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA805376) Mouse IgG2b OTI1B9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD56 (C-term) antibody

Anti-CD56/NCAM (DB 074)Western blot of CD56/NCAM: lane 1 – 100 ng; lane 2 – 200 ng; lane 3 – 500 ng of partial recombinant human CD56/NCAM. (NCAM1, N-terminal GST-CD56/NCAM, aa 611 – 710; Novus Biologicals, H00004684-Q01). Rabbit IgG A24-I Aff - Purified Hu, Ms, Rt C, E, ICC/IF, IP, P, WB
0.1 ml / €510.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD56 (C-term) antibody

Anti-CD56/NCAM (DB 074)Western blot of CD56/NCAM: lane 1 – 100 ng; lane 2 – 200 ng; lane 3 – 500 ng of partial recombinant human CD56/NCAM. (NCAM1, N-terminal GST-CD56/NCAM, aa 611 – 710; Novus Biologicals, H00004684-Q01). Rabbit IgG A24-I Aff - Purified Hu, Ms, Rt C, E, ICC/IF, IP, P, WB
50 µl / €340.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD56 antibody

Formalin-Paraffin Human colon ganglion stained with CD56 Antibody Cat.-No AM33261PU (Clone SPM128). Mouse IgG1 SPM128 Purified Hu, Rt, Ze C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

CD56 antibody

Formalin-Paraffin Human colon ganglion stained with CD56 Antibody Cat.-No AM33261PU (Clone SPM128). Mouse IgG1 SPM128 Purified Hu, Rt, Ze C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD56 antibody

Formalin-Paraffin Human colon ganglion stained with CD56 Antibody Cat.-No AM33261PU (Clone SPM128). Mouse IgG1 SPM128 Purified Hu, Rt, Ze C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

CD56 antibody

Formalin-Fixed, Paraffin-Embedded Human colon ganglion stained with CD56 Antibody Cat.-No AM50146PU (Clone SPM489). Mouse IgG1 SPM489 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

CD56 antibody

Formalin-Fixed, Paraffin-Embedded Human colon ganglion stained with CD56 Antibody Cat.-No AM50146PU (Clone SPM489). Mouse IgG1 SPM489 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD56 antibody

Formalin-Fixed, Paraffin-Embedded Human colon ganglion stained with CD56 Antibody Cat.-No AM50146PU (Clone SPM489). Mouse IgG1 SPM489 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

CD56 antibody

Predicted band size: 120-220 kDa . Positive control: Rat brain, rat hippocampus and mouse brain lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1,2,3: Rat brain, rat hippocampus and mouse brain Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Items 1 to 20 of 118 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  • LinkedIn