CD58 / LFA3 antibody

Principal name

CD58 / LFA3 antibody

Alternative names for CD58 / LFA3 antibody

Ag3, LFA-3, Lymphocyte function-associated antigen 3

SwissProt ID

P19256 (Human)

Gene ID

965 (CD58)

Available reactivities

Hu (Human), Sh (Sheep), Por (Porcine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Flow Cytometry (F), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Neutralisation (NEUT)

Background of CD58 / LFA3 antibody

CD58, or LFA-3, is a membrane glycoprotein of 55-70kD. It occurs in two forms, one transmembrane with a cytoplasmic domain, the other form anchored in the membrane via a glycosylphosphatidylinositol tail. The complete amino acid sequence of both forms has been deduced from cDNA. It is heavily N-glycosylated. CD58 is a cell adhesion molecule which plays a critical role in facilitation of antigen specific recognition through interaction with CD2 on T lymphocytes[1]. It is a member of the immunoglobulin superfamily of molecules. CD58 has a wide tissue distribution, being present on erythrocytes, platelets, monocytes, a subset of lymphocytes, bone marrow cells, epithelium and endothelial cells[2]. There are approximately 5,000 CD58 molecules on each erythrocyte. There is reduced expression of CD58 on haemopoietic cells in individuals with paroxysmal nocturnal haemoglobinuria. BRIC 5 was produced in response to erythrocytes. The functional affinity of BRIC 5 binding to erythrocytes is 4 x 108 M-1. It reacts by immunoblotting to non-reduced erythrocyte membranes. BRIC 5 is an indirect haemagglutinin. The antigen on erythrocytes is Pronase sensitive. BRIC 5 inhibits T cell rosetting.

General readings

Challa-Malladi,M., et al. (2011) Cancer Cell 20 (6), 728-740Patsopoulos NA, et al. (2011) Ann. Neurol. 70 (6), 897-912

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD58 / LFA3 antibody

Formalin-Fixed, Paraffin-Embedded Human Thymus stained with CD58 Antibody Cat.-No AM31149PU-N (Clone 2D11-B10) at 5 µg/ml after heat-induced antigen retrieval Mouse IgG2a 2D11-B10 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

CD58 / LFA3 antibody

Immunoperoxidase of monoclonal antibody to CD58 on formalin-fixed paraffin-embedded human lymphoma tissue [antibody concentration 2ug/ml] Mouse IgG2a 2D11-B10 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD58 / LFA3 antibody

Western blot analysis of extracts from HuvEc cells, using LFA3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD58 / LFA3 antibody

Western blot analysis of extracts of various cell lines, using CD58 antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD58 / LFA3 antibody

A typical staining pattern with the B-L28 monoclonal antibody of lymphocytes Mouse IgG1 B-L28 Azide Free Hu F
0.2 mg / €270.00
  Acris Antibodies GmbH

CD58 / LFA3 antibody

CD58 / LFA3 Mouse IgG1 B-L28 FITC Hu F
1ml (100 Tests) / €270.00
  Acris Antibodies GmbH

CD58 / LFA3 antibody

A typical staining pattern with the B-L28 monoclonal antibody of lymphocytes Mouse IgG1 B-L28 Purified Hu F
2ml (200 Tests) / €250.00
  Acris Antibodies GmbH

CD58 / LFA3 antibody

A typical staining pattern with the B-L28 monoclonal antibody of lymphocytes Mouse IgG1 B-L28 PE Hu F
1ml (100 Tests) / €290.00
  Acris Antibodies GmbH

CD58 / LFA3 antibody

CD58 / LFA3 Mouse IgG2a BRIC-5 Biotin Hu F
0.1 mg / €730.00
  Acris Antibodies GmbH

CD58 / LFA3 antibody

CD58 / LFA3 Mouse IgG2a BRIC-5 Purified Hu F, WB
0.2 mg / €500.00
  Acris Antibodies GmbH

CD58 / LFA3 antibody

Surface staining of human peripheral blood cells with anti-CD58 FITC 8SM3032F). Mouse IgG1 MEM-63 APC Hu, Por F
100 Tests / €290.00
  Acris Antibodies GmbH

CD58 / LFA3 antibody

Surface staining of human peripheral blood cells with anti-CD58 FITC (SM3032F) Mouse IgG1 MEM-63 Biotin Hu, Por F
0.1 mg / €260.00
  Acris Antibodies GmbH

CD58 / LFA3 antibody

Staining of human peripheral blood platelets with MOUSE ANTI HUMAN CD58:FITC (SM3032F). Mouse IgG1 MEM-63 FITC Hu F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD58 / LFA3 antibody

Staining of human peripheral blood granulocytes with MOUSE ANTI HUMAN CD58:RPE (SM3032R). Mouse IgG1 MEM-63 PE Hu F
100 Tests / €480.00
  Acris Antibodies GmbH

CD58 / LFA3 antibody

Western Blot analysis of CD58 expression in transfected 293T cell line (H00000965-T01) by CD58 MaxPab polyclonal antibody.

Lane 1: CD58 transfected lysate(27.5 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

CD58 / LFA3 antibody

Western Blot analysis of CD58 expression in transfected 293T cell line (H00000965-T01) by CD58 MaxPab polyclonal antibody.

Lane 1: CD58 transfected lysate(28.10 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CD58 / LFA3 antibody

CD58 / LFA3 Mouse IgG2a 3B12-D5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD58 / LFA3 antibody

CD58 / LFA3 Mouse IgG2a 1B6-A11 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

CD58 / LFA3 antibody

CD58 / LFA3 Mouse IgG1 MEM-63 Hu F
0.1 mg / €390.00
  Abnova Taiwan Corp.

CD58 / LFA3 antibody

Surface staining of human peripheral blood cells with CD58 monoclonal antibody, clone MEM-63 (FITC) ( Cat # MAB5006 ). Mouse IgG1 MEM-63 Hu F
100 reaction / €390.00
  Abnova Taiwan Corp.

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