CD61 / ITGB3 antibody

Principal name

CD61 / ITGB3 antibody

Alternative names for CD61 / ITGB3 antibody

Integrin beta-3, GP3A, GPIIIa, Platelet membrane glycoprotein IIIa

SwissProt ID

O54890 (Mouse), P05106 (Human)

Gene ID

3690 (ITGB3), 16416 (Itgb3)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Xen (Xenopus), Bab (Baboon), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine), Prim (Primate), Rb (Rabbit), Sh (Sheep)

Available hosts

Mouse, Hamster, Rabbit, Rat

Available applications

Frozen Sections (C), Paraffin Sections (P), Flow Cytometry (F), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Functional assay (FN), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Neutralisation (NEUT)

Background of CD61 / ITGB3 antibody

Intergins are a family of heterodimeric membrane glycoproteins expressed on diverse cell types which function as the major receptors for extracellular matrix and as cell-cell adhesion molecules. As adhesion molecules they play an important role in numerous biological processes such as platelet aggregation, inflammation, immune function, wound healing, tumour metastasis and tissue migration during embryogenesis. In addition integrins are involved in signaling pathways, transmitting signals both into an out from cells. All integrins consist of two non-covalently associated subunits, alpha and beta. At least 12 different alpha subunits and 8 beta subunits have been identified. The beta subunits all contain 56 conserved cysteines (except beta4 which has 48) which are arranged in four repeating units. The beta3 subunit is a 93kDa protein that contains a large loop in the N-terminus stabilized by intrachain disulphide bonding with the first cysteine-rich repeat.
Platelet glycoprotein GPIIb-IIIa is expressed on platelets and megakaryoblasts. It is constitutively expressed and becomes activated on triggered platelets. Platelet glycoprotein GPIIb-IIIa binds to fibrinogen, fibronectin, vWF, vitronectin and thrombospondin. Next to this it is also a receptor for several soluble adhesive proteins.Vitronectin receptor is expressed on endothelial cells, some B cells, monocytes/macrophages, platelets and tumour cells. Vitronectin receptor binds next to vitronectin to fibrinogen, vWF, thrombospondin, fibronectin, osteopontin and collagen. Defects in human beta3 integrin are a cause of Glanzmann thrombasthenia, which is an autosomal recessive disorder characterized by mucocutaneous bleeding and the inability of this integrin to recognize macromolecular or synthetic peptide ligands.

General readings

Sujoy Bhattacharya, et al. (2006) Biochem J. August 1; 397(Pt 3): 437447
Courter DL, et al. (2005) J Biol Chem Apr 01; 280(13): 12145-12151
Chandhoke SK, et al. (2004) J Cell Sci Mar 15; 117(Pt 8): 1431-1441

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD61 / ITGB3 antibody

Staining of Porcine peripheral blood platelets with Mouse Anti Porcine CD61:FITC (AM05881FC-N). Mouse IgG1 JM2E5 FITC Bov, Can, Eq, Hu, Por F
0.1 mg / €530.00
  Acris Antibodies GmbH

CD61 / ITGB3 antibody

Western blot analysis of extracts from NIH-3T3/A549 cells, using Integrin beta3 (Ab-785) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

Western blot analysis of extracts from 293 cells, using LMTK3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

Staining of C57Bl/6 bone marrow cells with 0.25 ug Armenian Hamster IgG Isotype Control Purified (open histogram) or 0.25 ug of Anti-Mouse/Rat CD61 (Integrin beta 3) Purified (filled histogram) followed byAnti-Armenian Hamster IgG Biotin and Streptavidin PE . Cells in the large scatter population were used for analysis. Hamster 2C9.G3 Purified Ms, Rt F, P
50 µg / €120.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

Staining of normal human peripheral blood platelets with 0.06 ug of Mouse IgG1 kappa Isotype Control Purified (left) or 0.06 ug of Anti-Human CD61 (Integrin beta 3) Purified (right) followed by 'F(ab')2 Anti-Mouse IgG PE followed by Anti-Human CD42b FITC . Mouse VI-PL2 Purified Bab, Can, Hu F, P, WB
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

Western blot analysis of Integrin beta3 expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

Western blot analysis of Integrin beta3 expression in NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

Western blot analysis of extracts from 293 cells using phospho-ITGB3-Y773 antibody and the same antibody preincubated with blocking peptide. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

Immunohistochemistry staining of Paraffin Bone marrow tissue by CD61 antibody (dilution: 1:25 - 1:100; visualization of staining: Cytoplasmic) Mouse IgG1 2F2 Purified Hu P
1 ml / €470.00
  OriGene Technologies, Inc.

CD61 / ITGB3 (N-term) antibody

Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

Western blot detection of Integrin beta 3(N-terminus) in 15ug and 25ug Leukocyte whole cell lysate using Integrin beta 3(N-terminus) mouse mAb (1:1000 diluted).Predicted band size:110KDa.Observed band size:110KDa. Mouse IgG1 3C12-G2-E4-H9 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

Western blot analysis of Integrin a3(CD49c) expression in HepG2 cell Rabbit IgG Purified Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

CD61 / ITGB3 Mouse IgG1 43.PL FITC Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD61 / ITGB3 antibody

CD61 / ITGB3 Mouse IgG1 43.PL Purified Hu F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD61 / ITGB3 antibody

CD61 / ITGB3 Mouse IgG1 43.PL PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

CD61 / ITGB3 antibody

CD61 / ITGB3 Mouse IgG1 JM2E5 Purified Bov, Can, Eq, Hu, Por C, F, IP, P, WB
0.1 mg / €270.00
  Acris Antibodies GmbH

CD61 / ITGB3 antibody

Formalin-Fixed, Paraffin-Embedded Human bone marrow stained with CD61 antibody Cat.-No. AM10070SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic staining of megakaryocytes. Mouse IgG1 2f2 Supernatant Hu P
1 ml / €530.00
  Acris Antibodies GmbH

CD61 / ITGB3 antibody

CD61 / ITGB3 Mouse IgG1 VIPL2 APC Hu, Prim F
100 Tests / €290.00
  Acris Antibodies GmbH

CD61 / ITGB3 antibody

CD61 / ITGB3 Mouse IgG1 VIPL2 Aff - Purified Hu, Prim C, F, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

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