CD61 / ITGB3 antibody

Principal name

CD61 / ITGB3 antibody

Alternative names for CD61 / ITGB3 antibody

Integrin beta-3, GP3A, GPIIIa, Platelet membrane glycoprotein IIIa

SwissProt ID

O54890 (Mouse), P05106 (Human)

Gene ID

3690 (ITGB3), 16416 (Itgb3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine), Prim (Primate), Mky (Monkey), Rb (Rabbit), Sh (Sheep), Bab (Baboon), Chk (Chicken)

Available hosts

Rabbit, Mouse, Hamster, Rat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Frozen Sections (C), Immunoprecipitation (IP), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD61 / ITGB3 antibody

Intergins are a family of heterodimeric membrane glycoproteins expressed on diverse cell types which function as the major receptors for extracellular matrix and as cell-cell adhesion molecules. As adhesion molecules they play an important role in numerous biological processes such as platelet aggregation, inflammation, immune function, wound healing, tumour metastasis and tissue migration during embryogenesis. In addition integrins are involved in signaling pathways, transmitting signals both into an out from cells. All integrins consist of two non-covalently associated subunits, alpha and beta. At least 12 different alpha subunits and 8 beta subunits have been identified. The beta subunits all contain 56 conserved cysteines (except beta4 which has 48) which are arranged in four repeating units. The beta3 subunit is a 93kDa protein that contains a large loop in the N-terminus stabilized by intrachain disulphide bonding with the first cysteine-rich repeat.
Platelet glycoprotein GPIIb-IIIa is expressed on platelets and megakaryoblasts. It is constitutively expressed and becomes activated on triggered platelets. Platelet glycoprotein GPIIb-IIIa binds to fibrinogen, fibronectin, vWF, vitronectin and thrombospondin. Next to this it is also a receptor for several soluble adhesive proteins.Vitronectin receptor is expressed on endothelial cells, some B cells, monocytes/macrophages, platelets and tumour cells. Vitronectin receptor binds next to vitronectin to fibrinogen, vWF, thrombospondin, fibronectin, osteopontin and collagen. Defects in human beta3 integrin are a cause of Glanzmann thrombasthenia, which is an autosomal recessive disorder characterized by mucocutaneous bleeding and the inability of this integrin to recognize macromolecular or synthetic peptide ligands.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD61 / ITGB3 antibody

Staining of Porcine peripheral blood platelets with Mouse Anti Porcine CD61:FITC (AM05881FC-N). Mouse IgG1 JM2E5 FITC Bov, Can, Eq, Hu, Por F
0.1 mg / €530.00
  Acris Antibodies GmbH

CD61 / ITGB3 antibody

  Rabbit polyclonal Integrin beta3 (Ab-785) antibody  
Western blot analysis of extracts from NIH-3T3/A549 cells, using Integrin beta3 (Ab-785) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Rabbit polyclonal Integrin beta3 (Tyr785) antibody(Phospho-specific)  
Western blot analysis of extracts from HeLa cells, HepG2 cells and HuvEc cells, using Integrin ß3 (phospho-Tyr785) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Hamster Anti-Mouse/Rat CD61 (Integrin beta 3) Purified (50 ug)  
Staining of C57Bl/6 bone marrow cells with 0.25 ug Armenian Hamster IgG Isotype Control Purified (open histogram) or 0.25 ug of Anti-Mouse/Rat CD61 (Integrin beta 3) Purified (filled histogram) followed byAnti-Armenian Hamster IgG Biotin and Streptavidin PE . Cells in the large scatter population were used for analysis. Hamster 2C9.G3 Purified Ms, Rt F, P
50 µg / €120.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Mouse Anti-Human CD61 (Integrin beta 3) Purified (100 ug)  
Staining of normal human peripheral blood platelets with 0.06 ug of Mouse IgG1 kappa Isotype Control Purified (left) or 0.06 ug of Anti-Human CD61 (Integrin beta 3) Purified (right) followed by 'F(ab')2 Anti-Mouse IgG PE followed by Anti-Human CD42b FITC . Mouse VI-PL2 Purified Bab, Can, Hu F, P, WB
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Anti-ITGB3 (Phospho-Tyr785) Rabbit Polyclonal Antibody  
Predicted band size: 87 kDa . Positive control: HUVEC cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: Treated with the peptide Lane2: HUVEC cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Rabbit Polyclonal Integrin beta3 Antibody  
Western blot analysis of Integrin beta3 expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Rabbit Polyclonal Integrin beta3 Antibody  
Western blot analysis of Integrin beta3 expression in NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Phospho-ITGB3-Y773 Rabbit Polyclonal Antibody  
Western blot analysis of extracts from 293 cells using phospho-ITGB3-Y773 antibody and the same antibody preincubated with blocking peptide. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Mouse Monoclonal ITGB3 (CD61) Antibody  
Immunohistochemistry staining of Paraffin Bone marrow tissue by CD61 antibody (dilution: 1:25 - 1:100; visualization of staining: Cytoplasmic) Mouse IgG1 2F2 Purified Hu P
1 ml / €600.00
  OriGene Technologies, Inc.

CD61 / ITGB3 (N-term) antibody

  Rabbit Polyclonal Anti-ITGB3 Antibody (N-Terminus)  
Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Rabbit Polyclonal Anti-ITGB3 Antibody (Internal)  
Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Mouse Monoclonal Integrin beta 3(N-terminus) Antibody  
Western blot detection of Integrin beta 3(N-terminus) in 15ug and 25ug Leukocyte whole cell lysate using Integrin beta 3(N-terminus) mouse mAb (1:1000 diluted).Predicted band size:110KDa.Observed band size:110KDa. Mouse IgG1 3C12-G2-E4-H9 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Rabbit Polyclonal Anti-Integrin a3 (CD49c) Antibody  
Western blot analysis of Integrin a3(CD49c) expression in HepG2 cell Rabbit IgG Purified Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Mouse Monoclonal anti-CD51/61 Antibody  
MDA-MB231 breast cancer cell line was stained with anti-human CD51/61, detected with anti-mouse DyLighttrade; 649, and nuclear counterstained with DAPI. Images were acquired with a TE300 fluorescence microscope with a 20x objective. Data provided by: Er Liu and John Nolan, La Jolla Bioengineering Institute Mouse 23C6 Purified Chk, Hu F, P
0.1 mg / €248.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Mouse monoclonal Anti-Integrin aVb3 Clone 23C6  
CD61 / ITGB3 Mouse IgG1 23C6 Purified Hu F, IP, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Mouse monoclonal Anti-Integrin b3 Clone F11  
CD61 / ITGB3 Mouse IgG1 F11 Purified Hu, Rt F, IP, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Mouse monoclonal Anti-Integrin b3 Clone MHF4  
CD61 / ITGB3 Mouse IgG2 MHF4 Purified Hu, Rt F, ICC/IF, IP, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

  Mouse monoclonal Anti-Integrin b3 Clone Y2/51  
CD61 / ITGB3 Mouse IgG1 Y2/51 Purified Hu F, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD61 / ITGB3 antibody

CD61 / ITGB3 Mouse IgG1 43.PL FITC Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

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