CD64 / FCGR1A antibody

Principal name

CD64 / FCGR1A antibody

Alternative names for CD64 / FCGR1A antibody

IgG Fc receptor I, FcgammaRIa, FcRI, Fc-gamma RI, Fc-gamma RIA, High affinity immunoglobulin gamma Fc receptor I

SwissProt ID

P12314 (Human), P26151 (Mouse)

Gene ID

2209 (FCGR1A)

Available reactivities

Hu (Human), Mky (Monkey), Bab (Baboon), Rhesus Mky (Rhesus Monkey), Ms (Mouse), Rt (Rat), Ye (Yeast)

Available hosts

Mouse, Rabbit

Available applications

Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP), Neutralisation (NEUT), Paraffin Sections (P)

Background of CD64 / FCGR1A antibody

CD64 (FcgammaRI) is a cell surface receptor for Fc region of IgG. It is composed of specific ligand binding alpha subunit and promiscuous gamma subunit, which is indispensable for tyrosine-based signaling. However, even the alpha subunit can transduce signals leading to cellular effector functions. The isoform FcgammaRIa1 binds human IgG with high affinity, has limited myeloid cell distribution, and a relatively large intracellular domain. Products of related genes include FcgammaRIb and FcgammaRIc isoforms, but these specify low affinity IgG receptors if functionally expressed at all. Besides a role in antigen clearance, FcgammaRI (a1) can potently enhance MHC class I and II antigen presentation in vitro and in vivo

General readings

1 Akerley WL, Guyre PM, Davis BH (1991) Neutrophil activation through high-affinity Fc gamma receptor using a monomeric antibody with unique properties. Blood 77, 607-615.
2 Pizza F, Davis BH, Hendrickson S, Mitchell J, Pace J, Bigelow NC, DiLauro P, Nagieri T (1996) Adaptation to eccentric exercise: effect on CD64 and CD11b/CD18 expression. J Applied Physiology 80, 47-55.
3 Schiff D, Rae J, Martin T, Davis BH, Curnutte J (1997) Increased phagocyte CD64 expression and improved Fc-receptor mediated phagocytosis following in vivo recombinant human interferon-g treatment of normal human subjects. Blood 90, 2987-94.
4 Pan LY, Mendel DB, Zurlo J, Guyre PM (1990) Regulation of the steady state level of Fc gamma RI mRNA by IFN-gamma and dexamethasone in human monocytes, neutrophils, and U-937 cells. J Immunol 145, 267-75.
5 Petroni KC, Shen L, Guyre PM (1988) Modulation of human polymorphonuclear leukocyte IgG Fc receptors and Fc receptor-mediated functions by IFN-gamma and glucocorticoids. J Immunol 140, 3467-72.
6 Davis, BH, Bigelow, NC, Curnutte JT, Ornvold, K (1995) Neutrophil CD64 expression: Potential diagnostic indicator of acute inflammation and therapeutic monitor of interferon-g therapy. Lab Hematol 1, 3-12.
7 Guyre, PM, Campbell, AS, Kniffin, WD, Fanger, MW (1990) Monocytes and polymorphonuclear neutrophils of patients with streptococcal pharyngitis express increased numbers of type I IgG Fc receptors. J Clin Invest 86, 1892-1986.
8 Davis BH (2005) Improved diagnostic approaches to infection/sepsis detection. Expert Rev Mol Diagn 5:193 – 207.
9 Herra CM, Keane CT, Whelan A (1996) Increased expression of Fc gamma receptors on neutrophils and monocytes may reflect ongoing bacterial infection. Journal of Medical Microbiology 44, 135-40.
10 Leino L, Sorvajarvi K, Katajisto J, Laine M, Lilius E, Pelliniemi T, Rajamaki A, Silvoniemi P, Nikoskelainen J (1997) Febrile infection changes the expression of IgG Fc receptors and complement receptors in human neutrophils in vivo. Clin Exp Immunol 107, 37-43.
11 Davis BH and Bigelow NC (2005) Comparison of neutrophil CD64 expression, manual myeloid immaturity counts, and automated hematology analyzer flags as indicators of infection or sepsis. Lab Hematol 11:137 – 147.
12 US Department of Labor, Occupational Safety and Health Administration. 29 CFR Part 1910. 1030, Occupational Exposure to Bloodborne Pathogens; Final Rule. Federal Register 235:64175-82. 1991
13 US Department of Health and Human Services. Biosafety in Microbiological and Biomedical Laboratories. HHS Publication (NIH) 93-8395. Washington: US Government Printing Office. 1993

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD64 / FCGR1A antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-FCGR1A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506343) Mouse IgG1 OTI3D3 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD64 / FCGR1A antibody

Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-FCGR1A mouse monoclonal antibody. (UM500062; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB74 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD64 / FCGR1A antibody

Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-FCGR1A mouse monoclonal antibody. (UM500062; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB74 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD64 / FCGR1A antibody

Western blot analysis of extracts of various cell lines, using FCGR1A antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD64 / FCGR1A antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-FCGR1A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506331) Mouse IgG1 OTI1A8 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD64 / FCGR1A antibody

Staining of normal human peripheral blood cells with 0.5 ug of  Mouse IgG1 kappa Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human CD64 Purified (filled histogram) followed by  Anti-Mouse IgG FITC .  Cells in the monocyte gate were used for analysis. Mouse 10.1 Purified Hu F, P
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD64 / FCGR1A antibody

WB Suggested Anti-FCGR1A Antibody; Titration: 1.0 ug/ml; Positive Control: NCI-H226 Whole Cell.FCGR1A is strongly supported by BioGPS gene expression data to be expressed in NCI-H226 Rabbit IgG Purified Hu, Ye WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD64 / FCGR1A antibody

Anti-FCGR1A mouse monoclonal antibody (TA506344) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FCGR1A(RC207487). Mouse IgG1 OTI1A9 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD64 / FCGR1A antibody

Anti-FCGR1A mouse monoclonal antibody (TA506345) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FCGR1A(RC207487). Mouse IgG1 OTI3H9 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD64 / FCGR1A antibody

Anti-FCGR1A mouse monoclonal antibody (TA506351) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FCGR1A(RC207487) at 1:100 Mouse IgG1 OTI1D8 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD64 / FCGR1A antibody

CD64 / FCGR1A Mouse IgG1 10.1 PE Hu F
50 Tests / €430.00
  Acris Antibodies GmbH

CD64 / FCGR1A antibody

The cell lysates of Jurkat and U937 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human FCGR1A antibody (1:2000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT37F7 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

CD64 / FCGR1A antibody

The cell lysates of Jurkat and U937 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human FCGR1A antibody (1:2000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT37F7 Purified Hu E, WB
50 µl / €220.00
  Acris Antibodies GmbH

CD64 / FCGR1A antibody

Staining of human peripheral blood monocytes with Mouse anti Human CD64 antibody FITC conjugated (SM1152F) Mouse IgG1 10.1 FITC Hu, Mky F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD64 / FCGR1A antibody

Staining of human peripheral blood monocytes with Mouse anti Human CD64 antibody FITC conjugated (SM1152F) Mouse IgG1 10.1 FITC Hu, Mky, Rhesus Mky F
25 µg / €190.00
  Acris Antibodies GmbH

CD64 / FCGR1A antibody

CD64 / FCGR1A Mouse IgG1 10.1 Low Endotoxin Hu, Mky F, FN
0.5 mg / €540.00
  Acris Antibodies GmbH

CD64 / FCGR1A antibody

SM1152P (Mouse anti Human CD64) staining of peripheral blood monocytes visualised with F(ab’)2 Rabbit anti Mouse IgG-FITC (SP1012F). Mouse IgG1 10.1 Purified Hu, Mky F
0.2 mg / €430.00
  Acris Antibodies GmbH

CD64 / FCGR1A antibody

SM1152P (Mouse anti Human CD64) staining of peripheral blood monocytes visualised with F(ab’)2 Rabbit anti Mouse IgG-FITC (SP1012F). Mouse IgG1 10.1 Purified Hu, Mky F
25 µg / €180.00
  Acris Antibodies GmbH

CD64 / FCGR1A antibody

Staining of human peripheral blood monocytes with Mouse Anti Human CD64-RPE (SM1152R). Mouse IgG1 10.1 PE Hu, Mky F
100 Tests / €440.00
  Acris Antibodies GmbH

CD64 / FCGR1A antibody

Staining of human peripheral blood monocytes with Mouse Anti Human CD64-RPE (SM1152RT). Mouse IgG1 10.1 PE Hu, Mky F
25 Tests / €220.00
  Acris Antibodies GmbH

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