CD66e / CEACAM5 antibody

Principal name

CD66e / CEACAM5 antibody

Alternative names for CD66e / CEACAM5 antibody

CEA, Carcinoembryonic antigen, Carcinoembryonic antigen-related cell adhesion molecule 5, Meconium antigen 100

SwissProt ID

P06731 (Human)

Gene ID

1048 (CEACAM5)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Radioimmunoassay (R), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunoprecipitation (IP), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Luminex (LMNX)

Background of CD66e / CEACAM5 antibody

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family (1). It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immuno-globulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker (2). CEACAM1 expression is down-regulated in many tumors indicating a tumor-suppressive function. The anti-tumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells (3). The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria (1).

General readings

1. Barnett, T.; Goebel, S. J.; Nothdurft, M. A.; Elting, J. J. : Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains. Genomics 3: 59-66, 1988.
2 Gold, P.; Freedman, S. O. : Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J. Exp. Med. 121: 439-462, 1965.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD66a/e (CEACAM1/5) antibody

Figure.3: Specificity testing of 4/3/17. 
BOSC cells were transiently transfected with expression vectors containing either the cDNA of CEACAM1, 3, 5, 6, 8 or are combinant transmembrane-anchored PSG1 fusion protein. Expression of the constructs was confirmed with monoclonal antibodies known to recognise the corresponding proteins (CEACAM1, 3, 5 and 6: D14HD11; CEACAM8: 80H3;PSG: BAP1; Green curves). An irrelevant monoclonal antibody served as a negative control (black curves). For specificity testing, protein G purified 4/3/17 was tested on all CEACAM transfectants. A positive signal was obtained with CEACAM1 and CEACAM5 expressing cells (Red curves). Mouse IgG1 4/3/17 Purified Hu C, E, F, ICC/IF, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Figure 2. FACS analysis of BOSC23 cells using 26/3/13 antibody Cat.-No DM1202. BOSC23 cells were transiently transfected with an expres-sion vector encoding either CEACAM5 (red curve) or an irrelevantprotein (control transfectant). Binding of 26/3/13 was detected witha PE conjugated secondary antibody. A positive signal was obtained only with CEACAM5 transfected cells. Mouse IgG1 26/3/13 Purified Hu C, E, F, ICC/IF, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Figure 2: Immunofluorescence Microscopy of CHO cells using D14HD11 Cat#DM1204. CHO cells were transfected with an expression vector encoding CEACAM1 (A). Untransfected CHO parental cells served as Negative Control (B). Binding of D14HD11 was visualized with a FITC-conjugated secondary antibody. Mouse IgG1 D14HD11 Purified Hu C, E, F, ICC/IF, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

  Luminex and ELISA validated purified CEACAM5 mouse monoclonal antibody clone (2B1, clone OTI2B12 (formerly 2B12)  
CEACAM5 ELISA with 2B12 Capture (TA600492) and 2B12 Detection (TA700500) Antibodies. Substrate used: Recombinant Human CEACAM5 (TP710040) Mouse IgG1 OTI2B12 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD66e / CEACAM5 antibody

  CEACAM5 mouse monoclonal antibody, clone OTI2B12 (formerly 2B12)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-CEACAM5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min, TA803181) Mouse IgG2a OTI2B12 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD66e / CEACAM5 antibody

  CEACAM5 mouse monoclonal antibody, clone OTI3E10 (formerly 3E10)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-CEACAM5 mouse monoclonal antibody. (TA803247) Dilution: 1:150 Mouse IgG1 OTI3E10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD66e / CEACAM5 antibody

  CEACAM5 mouse monoclonal antibody, clone OTI5F2 (formerly 5F2)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-CEACAM5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min, TA803249) Mouse IgG1 OTI5F2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD66e / CEACAM5 antibody

  CEACAM5 mouse monoclonal antibody, clone OTI1D4 (formerly 1D4)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-CEACAM5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA803413) Mouse IgG2b OTI1D4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD66e / CEACAM5 antibody

  CEACAM5 mouse monoclonal antibody, clone OTI1C2 (formerly 1C2)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-CEACAM5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min, TA803415) Mouse IgG2b OTI1C2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD66e / CEACAM5 antibody

  CEACAM5 mouse monoclonal antibody, clone OTI3D8 (formerly 3D8)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-CEACAM5 mouse monoclonal antibody. (TA803456; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG2a OTI3D8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded colon stained with CEA Antibody Cat.-No AM10076PU (Clone CEA31). Mouse IgG1 CEA31 Purified Hu, Mky C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded colon stained with CEA Antibody Cat.-No AM10076PU (Clone CEA31). Mouse IgG1 CEA31 Purified Hu, Mky C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded colon stained with CEA Antibody Cat.-No AM10076PU (Clone CEA31). Mouse IgG1 CEA31 Purified Hu, Mky C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded Human colon cancer stained with CEA Antibody Cat.-No AM32833PU (Clone COL-1). Mouse IgG2a COL-1 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded Human colon cancer stained with CEA Antibody Cat.-No AM32833PU (Clone COL-1). Mouse IgG2a COL-1 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded Human colon cancer stained with CEA Antibody Cat.-No AM32833PU (Clone COL-1). Mouse IgG2a COL-1 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded Human colon carcinoma stained with CEA Antibody Cat.-No AM33274PU (Clone SPM584). Mouse IgG2a SPM584 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded Human colon carcinoma stained with CEA Antibody Cat.-No AM33274PU (Clone SPM584). Mouse IgG2a SPM584 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded Human colon carcinoma stained with CEA Antibody Cat.-No AM33274PU (Clone SPM584). Mouse IgG2a SPM584 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded Human colon stained with CEA Antibody Cat.-No AM33275PU (Clone SPM551). Mouse IgG1 SPM551 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

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