CD66e / CEACAM5 antibody

Principal name

CD66e / CEACAM5 antibody

Alternative names for CD66e / CEACAM5 antibody

CEA, Carcinoembryonic antigen, Carcinoembryonic antigen-related cell adhesion molecule 5, Meconium antigen 100

SwissProt ID

P06731 (Human)

Gene ID

1048 (CEACAM5)

Available reactivities

Hu (Human), Ms (Mouse), Mky (Monkey), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat, Chicken

Available applications

Enzyme Immunoassay (E), Radioimmunoassay (R), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunoprecipitation (IP), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Functional assay (FN), Luminex (LMNX)

Background of CD66e / CEACAM5 antibody

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family (1). It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immuno-globulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker (2). CEACAM1 expression is down-regulated in many tumors indicating a tumor-suppressive function. The anti-tumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells (3). The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria (1).

General readings

This product has been used in:Nap M et al. Cross-reactivity with normal antigens in commercial anti-CEA sera, used for immunohistology. The need for tissue controls and absorptions. Am J Clin Pathol 79:25-31 (1983). PubMed PMID: 6401380
General / background references:Alkushi A et al. Immunoprofile of cervical and endometrial adenocarcinomas using a tissue microarray. Virchows Arch 442:271-7 (2003). PubMed PMID: 12647218
Morrison C et al. A comparison of CD10 to pCEA, MOC-31, and hepatocyte for the distinction of malignant tumors in the liver. Mod Pathol 15:1279-87 (2002). PubMed PMID: 12481008
Beauchemin N et al. Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res 252:243-9 (1999). PubMed PMID: 11501563
Shield PW et al. Immunocytochemical staining of cytologic specimens. How helpful is it? Am J Clin Pathol 105:157-62 (1996). PubMed PMID: 8607438
Sanders DS et al. Classification of CEA-related positivity in primary and metastatic malignant melanoma. J Pathol 172:343-8 (1994). PubMed PMID: 8207615
Sheahan K et al. Differential reactivities of carcinoembryonic antigen (CEA) and CEA-related monoclonal and polyclonal antibodies in common epithelial malignancies. Am J Clin Pathol 94:157-64 (1990). PubMed PMID: 1695478

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD66a/e (CEACAM1/5) antibody

Figure.3: Specificity testing of 4/3/17. 
BOSC cells were transiently transfected with expression vectors containing either the cDNA of CEACAM1, 3, 5, 6, 8 or are combinant transmembrane-anchored PSG1 fusion protein. Expression of the constructs was confirmed with monoclonal antibodies known to recognise the corresponding proteins (CEACAM1, 3, 5 and 6: D14HD11; CEACAM8: 80H3;PSG: BAP1; Green curves). An irrelevant monoclonal antibody served as a negative control (black curves). For specificity testing, protein G purified 4/3/17 was tested on all CEACAM transfectants. A positive signal was obtained with CEACAM1 and CEACAM5 expressing cells (Red curves). Mouse IgG1 4/3/17 Purified Hu C, E, F, ICC/IF, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Figure 2. FACS analysis of BOSC23 cells using 26/3/13 antibody Cat.-No DM1202. BOSC23 cells were transiently transfected with an expres-sion vector encoding either CEACAM5 (red curve) or an irrelevantprotein (control transfectant). Binding of 26/3/13 was detected witha PE conjugated secondary antibody. A positive signal was obtained only with CEACAM5 transfected cells. Mouse IgG1 26/3/13 Purified Hu C, E, F, ICC/IF, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Figure 2: Immunofluorescence Microscopy of CHO cells using D14HD11 Cat#DM1204. CHO cells were transfected with an expression vector encoding CEACAM1 (A). Untransfected CHO parental cells served as Negative Control (B). Binding of D14HD11 was visualized with a FITC-conjugated secondary antibody. Mouse IgG1 D14HD11 Purified Hu C, E, F, ICC/IF, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

CEACAM5 ELISA with 2B12 Capture (TA600492) and 2B12 Detection (TA700500) Antibodies. Substrate used: Recombinant Human CEACAM5 (TP710040) Mouse IgG1 OTI2B12 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD66e / CEACAM5 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-CEACAM5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min, TA803181) Mouse IgG2a OTI2B12 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD66e / CEACAM5 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-CEACAM5 mouse monoclonal antibody. (TA803247) Dilution: 1:150 Mouse IgG1 OTI3E10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD66e / CEACAM5 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-CEACAM5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min, TA803249) Mouse IgG1 OTI5F2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD66e / CEACAM5 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-CEACAM5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA803413) Mouse IgG2b OTI1D4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD66e / CEACAM5 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-CEACAM5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min, TA803415) Mouse IgG2b OTI1C2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD66e / CEACAM5 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-CEACAM5 mouse monoclonal antibody. (TA803456; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG2a OTI3D8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded colon stained with CEA Antibody Cat.-No AM10076PU (Clone CEA31). Mouse IgG1 CEA31 Purified Hu, Mky C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded colon stained with CEA Antibody Cat.-No AM10076PU (Clone CEA31). Mouse IgG1 CEA31 Purified Hu, Mky C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded colon stained with CEA Antibody Cat.-No AM10076PU (Clone CEA31). Mouse IgG1 CEA31 Purified Hu, Mky C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

AM11121PU CEA antibody staining of Human Colon Carcinoma. Mouse IgG1 SPM506 Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

AM11121PU CEA antibody staining of Human Colon Carcinoma. Mouse IgG1 SPM506 Purified Hu P
1 ml / €500.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

AM11121PU CEA antibody staining of Human Colon Carcinoma. Mouse IgG1 SPM506 Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded Human colon cancer stained with CEA Antibody Cat.-No AM32833PU (Clone COL-1). Mouse IgG2a COL-1 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded Human colon cancer stained with CEA Antibody Cat.-No AM32833PU (Clone COL-1). Mouse IgG2a COL-1 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded Human colon cancer stained with CEA Antibody Cat.-No AM32833PU (Clone COL-1). Mouse IgG2a COL-1 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

CD66e / CEACAM5 antibody

Formalin-Fixed, Paraffin-Embedded Human colon carcinoma stained with CEA Antibody Cat.-No AM33274PU (Clone SPM584). Mouse IgG2a SPM584 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

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