CD68 antibody

Principal name

CD68 antibody

Alternative names for CD68 antibody

Gp110, Macrosialin, Macrophage marker

SwissProt ID

P31996 (Mouse), P34810 (Human), Q4FZY1 (Rat)

Gene ID

968 (CD68), 287435 (Cd68), 12514

Available reactivities

Hu (Human), Bov (Bovine), Rt (Rat), Ms (Mouse), GP (Guinea Pig), Mky (Monkey), Fe (Feline), Por (Porcine)

Available hosts

Mouse, Rat, Rabbit

Available applications

Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Radioimmunoassay (R), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Selected product citations ‐ of SM1550P

1. Kirby AC, Beattie L, Maroof A, van Rooijen N, Kaye PM. SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages. Am J Pathol. 2009 Sep;175(3):1107-15. doi: 10.2353/ajpath.2009.090258. Epub 2009 Jul 30. PubMed PMID: 19644016.
2. Zimmermann O, Homann JM, Bangert A, Müller AM, Hristov G, Goeser S, et al. Successful use of mRNA-nucleofection for overexpression of interleukin-10 in murine monocytes/macrophages for anti-inflammatory therapy in a murine model of autoimmune myocarditis. J Am Heart Assoc. 2012 Dec;1(6):e003293. doi: 10.1161/JAHA.112.003293. Epub 2012 Dec 19. PubMed PMID: 23316321. 
3. Jehle, J;Hoyer, FF;Schöne, B;Pfeifer, P;Schild, K;Jenniches, I;Bindila, L;Lutz, B;Lütjohann, D;Zimmer, A;Nickenig, G. Myeloid-Specific Deletion of Diacylglycerol Lipase α Inhibits Atherogenesis in ApoE-Deficient Mice. PLoS ONE 2016, e0146267, 11, 1. PubMed PMID: 26731274.

Background of CD68 antibody

Kinins are important biologically active peptides that mediate cardiovascular homeostasis, inflammation and nociception. Bradykinin, the major effector peptide of the kallikrein-kinin system, is regulated by angiotensin-converting enzyme (ACE), which degrades the peptide. Bradykinin normally exerts its effects through the activation of two seven transmembrane G-protein coupled receptors, named B1 and B2. The B2 receptor is constitutively expressed and preferentially binds full length bradykinin. Deletion of the B2 receptor leads to salt-sensitive hypertension and altered nociception in mice. The B1 receptor binds to derivatives of bradykinin and kallidin, which are produced by carboxypeptidase action to generate the products des-Arg9-bradykinin and des-Arg10-kallidin, respectively. The expression of the B1 receptor is inducible by inflammatory mediators, such as bacterial lipopolysaccharide (LPS) and cytokines. The B1 and B2 receptors represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases.

General readings

This product has been used in:Horny HP et al. Immunoreactivity of normal and neoplastic human tissue mast cells with macrophage-associated antibodies, with special reference to the recently developed monoclonal antibody PG-M1. Hum Pathol 24:355-8 (1993). PubMed PMID: 8491475
Kaiserling E et al. Aberrant expression of macrophage-associated antigens (CD68 and Ki-M1P) by Schwann cells in reactive and neoplastic neural tissue. Light- and electron-microscopic findings. Mod Pathol 6:463-8 (1993). PubMed PMID: 8415593
Thiele J et al. Macrophages in normal human bone marrow and in chronic myeloproliferative disorders: an immunohistochemical and morphometric study by a new monoclonal antibody (PG-M1) on trephine biopsies. Virchows Arch A Pathol Anat Histopathol 421:33-9 (1992). PubMed PMID: 1636247

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD68 antibody

Figure 1. Staining of rat liver, with induced hepatocellular damage, with Mouse anti Rat CD68 antibody Cat.-No BM4000 Mouse IgG1 ED1 Purified Bov, Rt C, F, ICC/IF, IP, P, R, WB
0.25 mg / €620.00
  Acris Antibodies GmbH

CD68 antibody

Figure 1. Staining of rat liver, with induced hepatocellular damage, with Mouse anti Rat CD68 antibody Cat.-No BM4000 Mouse IgG1 ED1 Purified Bov, Rt C, F, ICC/IF, IP, P, R, WB

Regular Price: 0.1 mg / €370.00

Special Price: 0.1 mg / €259.00

  Acris Antibodies GmbH

CD68 antibody

Staining of FFPE Mouse spleen with Rat anti Mouse CD68 Antibody Cat.-No SM1550PS (Clone FA-11) at 2 µg/ml. Antibody positive in cytoplasm of macrophages. Rat IgG2a FA-11 Purified Ms C, F, ICC/IF, IP, P, WB
0.25 mg / €550.00
  Acris Antibodies GmbH

CD68 antibody

Staining of FFPE Mouse spleen with Rat anti Mouse CD68 Antibody Cat.-No SM1550PS (Clone FA-11) at 2 µg/ml. Antibody positive in cytoplasm of macrophages. Rat IgG2a FA-11 Purified Ms C, F, ICC/IF, IP, P, WB
0.1 mg / €250.00
  Acris Antibodies GmbH

CD68 antibody

CD68 Mouse IgG1 ED1 Biotin Bov, Rt C, F
100 Tests / €530.00
  Acris Antibodies GmbH

CD68 antibody

Staining of rat peritoneal macrophages cells with Mouse Permeabilised Anti Rat CD68 antibody FITC conjugated (BM4000F). Mouse IgG1 ED1 FITC Bov, Rt F
0.1 mg / €670.00
  Acris Antibodies GmbH

CD68 antibody

Staining of rat peritoneal macrophages cells with Mouse Anti RAT CD68 antibody RPE conjugated (BM4000R). Mouse IgG1 ED1 PE Bov, Rt F
100 Tests / €670.00
  Acris Antibodies GmbH

CD68 antibody

CD68 Rat IgG2a FA-11 Azide Free Ms C, F, IP, WB

Regular Price: 0.2 mg / €370.00

Special Price: 0.2 mg / €259.00

  Acris Antibodies GmbH

CD68 antibody

Staining of mouse peritoneal macrophages cells with Rat Anti Mouse CD68 antibody -Biotin (Cat.-No SM1550B). Rat IgG2a FA-11 Biotin Ms F
0.1 mg / €530.00
  Acris Antibodies GmbH

CD68 antibody

Staining of permeabilised Mouse peritoneal macrophages cells with CD68 antibody -FITC (Cat.-No SM1550F). Rat IgG2a FA-11 FITC Ms F
0.1 mg / €350.00
  Acris Antibodies GmbH

CD68 antibody

CD68 Rat IgG2a FA-11 FITC Ms F
50 µg / €240.00
  Acris Antibodies GmbH

CD68 antibody

Staining of Mouse peritoneal macrophages with Rat anti Mouse CD68 antibody -RPE (SM1550R) following permeablisation with Leucoperm. Rat IgG2a FA-11 PE Ms F
100 Tests / €410.00
  Acris Antibodies GmbH

CD68 antibody

CD68 Mouse IgG1 UMAB150 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

CD68 antibody

CD68 Mouse IgG1 UMAB150 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

CD68 antibody

Immunohistochemical staining of paraffin-embedded Human bladder tissue within the normal limits using anti-CD68 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802949) Mouse IgG1 OTI3B6 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD68 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CD68 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802952) Mouse IgG1 OTI4G1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD68 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-CD68 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802955) Mouse IgG2b OTI8A4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD68 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-CD68 mouse monoclonal antibody. (TA803041; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG2b OTI7D3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD68 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-CD68 mouse monoclonal antibody. (TA803067) Dilution: 1:150 Mouse IgG1 OTI12C5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD68 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CD68 mouse monoclonal antibody. (TA803288) Dilution: 1:150 Mouse IgG2a OTI1E6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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