CD7 antibody

Principal name

CD7 antibody

Alternative names for CD7 antibody

GP40, TP41, Leu-9, T-cell leukemia antigen

SwissProt ID

P09564 (Human), P50283 (Mouse)

Gene ID

924 (CD7), 3690 (ITGB3), 12516 (Cd7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rat, Rabbit, Goat

Available applications

Flow Cytometry (F), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Microcytotoxicity (MC)

Background of CD7 antibody

The 124-1D1 monoclonal antibody reacts with human CD7, also known as gp40 and Leu9. CD7, a 40 kD receptor, is a member of the immunoglobulin gene superfamily. The N-terminal amino acid sequence (aa1-107) is highly homologous to Ig kappa light chain sequence while the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T lymphocytes, and T cell leukemias. It is also found on natural killer cells, a small suppopulation of normal B cells and on maligant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity, as measured by calcium flux, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3#39-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. A clonogenic subpopulation of human CD34(+) CD38(-) cord blood cells that express CD45RA and HLA-DR and high levels of the CD7 has been reported. These cells possess the capacity for lymphopoiesis. They can generate B-cells, natural killer cells, and dendritic cells but do not possess the capacity to develop into myeloid cells or erythroid cells. The CD7(+) phenotype distinguishes primitive human lymphoid progenitors from pluripotent stem cells. Furthermore, it has been suggested that CD7 co-operates with CD28 during Treg function, as mice deficient in both CD28 and CD7 have reduced total numbers of Tregs and these Tregs have reduced suppressive activity.

General readings

1. Alaibac M, Pigozzi B, Belloni-Fortina A, Michelotto A, Saponeri A, Peserico A. CD7 expression in reactive and malignant human skin T-lymphocytes. Anticancer Res. 2003
May-Jun;23(3B):2707-10.
2. Lam GK, Liao HX, Xue Y, Alam SM, Scearce RM, Kaufman RE, Sempowski GD, Haynes BF. Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma. J Clin Immunol. 2005 Jan;25(1):41-9.
3. Nishimura M, Takanashi M, Okazaki H, Satake M, Nakajima K.: Role of CD7 expressed in lung microvascular endothelial cells as Fc receptor for immunoglobulin M. Endothelium. 2006 Jul-Aug;13(4):287-92.
4. Chang H, Yeung J, Brandwein J, Yi QL.: CD7 expression predicts poor disease free survival and post-remission survival in patients with acute myeloid leukemia and normal
karyotype. Leuk Res. 2007 Feb;31(2):157-62. Epub 2006 Jul 11.
5. Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD7 antibody

Staining of Human peripheral blood lymphocytes with Mouse anti Human CD7 antibody, clone CT7 (Cat.-No SM1074P). Mouse IgG2a LT7 Purified Hu C, F, IP
0.2 mg / €440.00
  Acris Antibodies GmbH

CD7 antibody

Staining of Human peripheral blood lymphocytes with Mouse anti Human CD7 antibody, clone CT7 (Cat.-No SM1074P). Mouse IgG2a LT7 Purified Hu C, F, IP
0.1 mg / €280.00
  Acris Antibodies GmbH

CD7 antibody

Staining of Human peripheral blood lymphocytes with Mouse anti Human CD7 antibody, clone CT7 (Cat.-No SM1074P). Mouse IgG2a LT7 Purified Hu C, F, IP
25 µg / €180.00
  Acris Antibodies GmbH

CD7 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 μm) stained with anti-CD7 antibody (DB 114) shows strong immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG C21-Q Aff - Purified Hu C, P
0.1 ml / €320.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD7 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 μm) stained with anti-CD7 antibody (DB 114) shows strong immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG C21-Q Aff - Purified Hu C, P
0.2 ml / €440.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD7 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 μm) stained with anti-CD7 antibody (DB 114) shows strong immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG C21-Q Aff - Purified Hu C, P
0.5 ml / €550.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD7 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 μm) stained with anti-CD7 antibody (DB 114) shows strong immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG C21-Q Aff - Purified Hu C, P
1 ml / €870.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD7 antibody

Human tonsil stained with anti-CD7 antibody (AP09592PU) Rabbit IgG Aff - Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

CD7 antibody

Human tonsil stained with anti-CD7 antibody (AP09592PU) Rabbit IgG Aff - Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

CD7 antibody

Human tonsil stained with anti-CD7 antibody (AP09592PU) Rabbit IgG Aff - Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

CD7 (132-146) antibody

(0.5ug/ml) staining of Human Thymus lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD7 antibody

Staining of normal human peripheral blood cells with 0.5 ug of  Mouse IgG1 K Isotype Control Purified (open histogram) or 0.5 ug of Anti-human CD7 Purified (filled histogram) followed by F(ab')2 Anti-Mouse IgG PE .  Cells in the lymphocyte gate were used for analysis. Mouse eBio124-1D1 (124-1D1) Purified Hu F
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD7 antibody

Immunohistochemistry staining of Paraffin Tonsil, Lymph node, Peripheral T-cell lymphoma tissue by CD7 antibody (dilution: 1:100 - 1:500; visualization of staining: Membranous) Mouse IgG1 MRQ-56 Purified Hu P
1 ml / €480.00
  OriGene Technologies, Inc.

CD7 antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-CD7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506337) Mouse IgG1 OTI1A6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD7 antibody

CD7 Mouse IgG2a MG34 Biotin Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD7 antibody

CD7 Mouse IgG2a MG34 FITC Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD7 antibody

CD7 Mouse IgG2a MG34 Purified Hu F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD7 antibody

Figure 1. Peripheral Blood Lymphocytes Stained with AM05172RP-N antibody. Mouse IgG2a MG34 PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

CD7 antibody

Spleen: Formalin-Fixed Paraffin-Embedded (FFPE) Mouse IgG MEM-186 Purified Hu F, IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD7 antibody

Immunohistochemistry on frozen sections: Stainig with AM26054PU-N on human tonsil Mouse IgG1 142.9 Aff - Purified Hu C, F
0.1 mg / €280.00
  Acris Antibodies GmbH

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