CD71 / TFRC antibody

Principal name

CD71 / TFRC antibody

Alternative names for CD71 / TFRC antibody

TfR1, p90, Transferrin receptor protein 1

SwissProt ID

P02786 (Human), Q2V905 (Horse), Q62351 (Mouse), Q8HZV3 (Pig), Q90997 (Chick), Q99376 (Rat), Q9GLD3 (Canfa), Q9MYZ3 (Felca)

Gene ID

7037 (TFRC), 22042 (Tfrc), 7036 (TFR2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Can (Canine), Fe (Feline), Por (Porcine), Bov (Bovine), Rhesus Mky (Rhesus Monkey), Md (Mustelid), Chk (Chicken)

Available hosts

Mouse, Rat, Rabbit, Goat

Available applications

Frozen Sections (C), Flow Cytometry (F), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunoelectron Microscopy (EM), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Paraffin Sections (P), Functional assay (FN)

Background of CD71 / TFRC antibody

Cellular uptake of iron occurs via receptor mediated endocytosis of ligand occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Useful in studies of dividing haematopoietic and tumour cell populations, and metabolic activity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C terminal binding site. The antigen is present on most dividing cells, including normally cycling in vivo hematopoietic progenitor cells, mitogenically stimulated cells in vitro, some primary tumor cells and most proliferating cells in vitro.
The transferrin Receptor has been structurally characterized as a sulfide bound dimer of identical glycoprotein subunits of 95 kDa. The transferrin receptor is not present on resting blood lymphocytes. On PBL, the receptor appears after activation. The expression of transferrin receptor is coordinately regulated with cell growth. Present on T and B cell lines. The soluble (or serum) transferrin receptor (sTfR) is a circulating truncated form of the membrane receptor protein; it is an 85 kDa glycoprotein forming in serum a 320 kDa complex with diferric transferrin.The most important clinical use of the sTfR determination is in the differential diagnosis between iron deficiency anaemia and the anaemia of chronic disease.

General readings

1. Rouault TA: How mammals acquire and distribute iron needed for oxygen-based metabolism. PLoS Biol. 2003 Dec;1(3):E79.
2. Taketani S: Aquisition, mobilization and utilization of cellular iron and heme: endless findings and growing evidence of tight regulation. Tohoku J Exp Med. 2005
Apr;205(4):297-318.
3. Graham RM, Chua AC, Herbison CE, Olynyk JK, Trinder D: Liver iron transport. World J Gastroenterol. 2007 Sep 21;13(35):4725-36.
4. Graham RM, Reutens GM, Herbison CE, Delima RD, Chua AC, Olynyk JK, Trinder D: Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron.
J Hepatol. 2008 Feb;48(2):327-34.
5. Leukocyte Typing IV., Knapp W. et al. (Eds.), Oxford University Press (1989).
6. Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD71 / TFRC (N-term) antibody

Staining of Human Breast lysate using CD71 / TFRC antibody Cat.-No AP32133PU-N at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

Surface staining of mouse bone marrow with Anti-Mouse CD71 PE and Anti-Human/Mouse CD45R (B220) FITC .  Cells in the lymphoid population were used for analysis. Rat R17217 (RI7 217.1.4) Purified Ms F
0.1 mg / €130.00
  OriGene Technologies, Inc.

CD71 / TFRC antibody

Western blot analysis of CD71 Antibody (C-term) (Cat. #TA324761) in Hela cell line lysates (35ug/lane). CD71 (arrow) was detected using the purified Pab. Rabbit IgG Purified Hu F, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CD71 / TFRC antibody

Immunohistochemistry staining of Paraffin Bone marrow tissue by CD71 antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic, membranous) Mouse IgG1 MRQ-48 Purified Hu P
1 ml / €480.00
  OriGene Technologies, Inc.

CD71 / TFRC antibody

Western blot analysis of extracts of various cell lines, using TFRC antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD71 / TFRC antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TFRC (RC200980, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TFRC. Rabbit IgG Purified Hu, Mky E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD71 / TFRC antibody

CD71 / TFRC Rat IgG2a R17217.1.4 Biotin Ms F
0.3 mg / €500.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Rat IgG2a R17217.1.4 Biotin Ms F
0.1 mg / €250.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Rat IgG2a R17217.1.4 FITC Ms C, F, IP
0.5 mg / €600.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Rat IgG2a R17217.1.4 FITC Ms F
0.1 mg / €250.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Rat IgG2a R17217.1.4 Purified Ms F
0.2 mg / €380.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Rat IgG2a R17217.1.4 PE Ms C, F, IP
0.3 mg / €780.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Rat IgG2a R17217.1.4 PE Ms C, F, IP
50 µg / €280.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Mouse IgG1 BGX.24 FITC Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Mouse IgG1 BGX.24 Purified Hu F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Mouse IgG1 BGX.24 PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Rat IgG2a 8D3 Biotin Ms F
25 µg / €180.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Rat IgG2a 8D3 Low Endotoxin Ms C, F, FN
0.5 mg / €540.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Rat IgG2a RI7217 Biotin Ms F
0.5 mg / €380.00
  Acris Antibodies GmbH

CD71 / TFRC antibody

CD71 / TFRC Rat IgG2a RI7217 FITC Ms F
0.5 mg / €360.00
  Acris Antibodies GmbH

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