CD74 antibody

Principal name

CD74 antibody

Alternative names for CD74 antibody

p33, DHLAG, HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain

SwissProt ID

P04233 (Human), P04441 (Mouse), P10247 (Rat)

Gene ID

972 (CD74), 16149 (Cd74), 25599

Available reactivities

Hu (Human), Ms (Mouse), Bab (Baboon), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Immunoprecipitation (IP), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E)

Background of CD74 antibody

CD74 is a non-polymorphic type II integral membrane protein. It has a short N-terminal cytoplasmic tail of 28 amino acids, followed by a single 24-aa transmembrane region and an approximately 150-aa lumenal domain (1). The CD74 chain is thought to function mainly as an MHC class II chaperone, which promotes ER exit of MHC class II molecules, directs them to endocytic compartments, prevents peptide binding in the ER, and contributes to peptide editing in the MHC class II compartment. Class II MHC and Ii expression was believed to be restricted to classical antigen-presenting cells (APC); however, during inflammation, other cell types, including mucosal epithelial cells, have also been reported to express class II MHC molecules (2). Experiments that investigate cell-surface CD74 are complicated by the fact that CD74 remains on the cell surface for a very short time. The surface half-life of CD74 was calculated to be fewer than 10 minutes (3). CD74 however has also recently been shown to have a role as an accessory-signaling molecule because of its high-affinity binding to the pro-inflammatory cytokine, macrophage migration-inhibitory factor (MIF) (3). The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases (4).

General readings

Claesson L. et al. (1983) Proc Natl Acad Sci U S A. 80(24):7395-9.Bakke O. et al. (1990) Cell. 63(4):707-16.Strubin M. et al. (1984) EMBO J. 3(4):869-72.

  1. Quick-Filters:
  2. Cited (3)
  3. Highly Validated (3)

Items 1 to 20 of 43 total

per page
Page:
  1. 1
  2. 2
  3. 3

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD74 antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with CD74 Antibody Cat.-No AM32811PU (Clone LN2). Mouse IgG1 LN2 Purified Hu, Ms C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

CD74 antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with CD74 Antibody Cat.-No AM32811PU (Clone LN2). Mouse IgG1 LN2 Purified Bab, Hu, Ms C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD74 antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with CD74 Antibody Cat.-No AM32811PU (Clone LN2). Mouse IgG1 LN2 Purified Bab, Hu, Ms C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

CD74 antibody

  Rabbit polyclonal antibody to CD74 (CD74 molecule, major histocompatibility complex, class II invariant chain)  
CD74 antibody [N1N2], N-term detects CD74 protein by Western blot analysis. A. 30 ug GL261 whole cell lysate/extract. 12 % SDS-PAGE. CD74 antibody [N1N2], N-term (TA308865) dilution: 1:1000 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD74 antibody

  CD74 mouse monoclonal antibody, clone OTI1G10 (formerly 1G10)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-CD74 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA507336) Mouse IgG1 OTI1G10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD74 antibody

  CD74 mouse monoclonal antibody, clone OTI1H3 (formerly 1H3)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-CD74 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA507339) Mouse IgG1 OTI1H3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD74 antibody

Formalin Fixed, Formalin-Paraffin Human tonsil stained with CD74 Antibody Cat.-No AM33264PU (Clone SPM523). Note membrane staining. Mouse IgG1 SPM523 Purified Hu, Ms C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

CD74 antibody

Formalin Fixed, Formalin-Paraffin Human tonsil stained with CD74 Antibody Cat.-No AM33264PU (Clone SPM523). Note membrane staining. Mouse IgG1 SPM523 Purified Hu, Ms C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD74 antibody

Formalin Fixed, Formalin-Paraffin Human tonsil stained with CD74 Antibody Cat.-No AM33264PU (Clone SPM523). Note membrane staining. Mouse IgG1 SPM523 Purified Hu, Ms C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

CD74 antibody

  Mouse Monoclonal anti-CD74 Antibody  
Western blot of CD74 from IP N87 lysates mixed with macrophage migration inhibitory factor (MIF). Mouse IgG1 PIN.1 Purified Hu C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD74 antibody

  Mouse Monoclonal CD74 Antibody  
Immunohistochemistry staining of Paraffin Tonsil tissue by CD74 antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic, membranous) Mouse IgG1 LN2 Purified Hu P
1 ml / €560.00
  OriGene Technologies, Inc.

CD74 antibody

  Rabbit anti-CD74 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using CD74 antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD74 (alpha+beta) antibody

  Goat Anti-CD74 Antibody  
TA334191 (0.03µg/ml) staining of Human Tonsil lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD74 (159-171) antibody

  Goat Anti-CD74 (aa159-171) Antibody  
TA334192 (0.01µg/ml) staining of Human Tonsil lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD74 antibody

  Mouse monoclonal Anti-HLADRCD74 Clone By2  
CD74 Mouse IgG1 By2 Purified Hu F, ICC/IF, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD74 antibody

  Mouse monoclonal Anti-HLADRCD74 Clone BU43  
CD74 Mouse IgM BU43 Purified Hu F, IP, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD74 antibody

  Mouse Monoclonal anti-CD74 Antibody  
Western Blot analysis of Ramos cell lysate with CD74 antibody Mouse IgG1 SPM523 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD74 antibody

CD74 Mouse IgG1 Bu45 FITC Hu F
0.1 mg / €390.00
  Acris Antibodies GmbH

CD74 antibody

CD74 Mouse IgG1 Bu45 FITC Hu F
25 µg / €190.00
  Acris Antibodies GmbH

CD74 antibody

CD74 Mouse IgG1 Bu45 Purified Hu C, F, FN, ICC/IF, IP
0.2 mg / €430.00
  Acris Antibodies GmbH

Items 1 to 20 of 43 total

per page
Page:
  1. 1
  2. 2
  3. 3
  • LinkedIn