CD74 antibody

Principal name

CD74 antibody

Alternative names for CD74 antibody

p33, DHLAG, HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain

SwissProt ID

P04233 (Human), P04441 (Mouse), P10247 (Rat)

Gene ID

972 (CD74), 16149 (Cd74), 25599

Available reactivities

Hu (Human), Ms (Mouse), Bab (Baboon), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Immunoprecipitation (IP), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E)

Background of CD74 antibody

CD74 is a non-polymorphic type II integral membrane protein. It has a short N-terminal cytoplasmic tail of 28 amino acids, followed by a single 24-aa transmembrane region and an approximately 150-aa lumenal domain (1). The CD74 chain is thought to function mainly as an MHC class II chaperone, which promotes ER exit of MHC class II molecules, directs them to endocytic compartments, prevents peptide binding in the ER, and contributes to peptide editing in the MHC class II compartment. Class II MHC and Ii expression was believed to be restricted to classical antigen-presenting cells (APC); however, during inflammation, other cell types, including mucosal epithelial cells, have also been reported to express class II MHC molecules (2). Experiments that investigate cell-surface CD74 are complicated by the fact that CD74 remains on the cell surface for a very short time. The surface half-life of CD74 was calculated to be fewer than 10 minutes (3). CD74 however has also recently been shown to have a role as an accessory-signaling molecule because of its high-affinity binding to the pro-inflammatory cytokine, macrophage migration-inhibitory factor (MIF) (3). The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases (4).

General readings

Claesson L. et al. (1983) Proc Natl Acad Sci U S A. 80(24):7395-9.Bakke O. et al. (1990) Cell. 63(4):707-16.Strubin M. et al. (1984) EMBO J. 3(4):869-72.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD74 antibody

CD74 Mouse IgG1 Bu45 Purified Hu C, F, FN, ICC/IF, IP
0.2 mg / €440.00
  OriGene Technologies GmbH

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