CD79a antibody

Principal name

CD79a antibody

Alternative names for CD79a antibody

IGA, MB1, B-Cell marker, B-cell antigen receptor complex-associated protein alpha-chain, MB-1 membrane glycoprotein, Surface IgM-associated protein, Membrane-bound immunoglobulin-associated protein

SwissProt ID

P11911 (Mouse), P11912 (Human), P40293 (Bovin)

Gene ID

973 (CD79A)

Available reactivities

Hu (Human), Bov (Bovine), Chk (Chicken), Eq (Equine), GP (Guinea Pig), Ms (Mouse), Por (Porcine), Rb (Rabbit), Mky (Monkey), Can (Canine), Rt (Rat), Bison, Deer, Op (Opossum), Prim (Primate), Ye (Yeast)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Paraffin Sections (P), Flow Cytometry (F), Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of CD79a antibody

CD79 is a signaling unit of the B-cell receptor complex, which transmits signals of activation, growth, and differentiation (Huang, 2011). It is composed of CD79a and CD79b components expressed almost exclusively on B cells and their neoplasm (Chu, 2001). These membrane proteins are expressed as a disulphide-linked heterodimer that associates non-covalently with membrane Ig (mIg) to form the BCR complex, a multiprotein structure that is pivotal to antigen recognition and signal transduction. Whilst the mIg component is responsible for binding antigen, the cytoplasmic tail of the mIg heavy chain is very short and therefore incapable of transmitting activating signals to the inside. Thus, it is the CD79a-b subunits of the BCR that mediate these intracellular signaling events (Duncan, 2010).
CD79a and CD79b antibodies are useful in the differential diagnosis of B-cell neoplasms from T-cell or myeloid neoplasms, or L and H lymphocyte predominance Hodgkin's lymphoma from classic Hodgkin's lymphoma. In addition, antibody to CD79a and CD79b is useful as a marker in the diagnosis of precursor B-acute lymphoblastic leukemia (pre-B-ALL) because many of these tumors are negative for other B-cell markers, such as CD20 and CD45RA (Chu, 2001). CD79a-b antibody has been effective at targeting B cell lymphomas and depleting B cells in animal models. Antibody against human CD79, as well as those coupled to potent cytotoxic agents, are effective at killing human B cell lymphoma cells both in vitro and in mouse chimeras. Mouse CD79 antibody has been shown to be effective in depleting B cells and at ameliorating autoimmune disease in MRL/lpr mice (Haggart, 2013). CD79a and CD79b are attractive targets for the use of ADCs (antibody–drug conjugates) because they are B-cell–specific, expressed in non-Hodgkin lymphomas (NHL), and are trafficked to a lysosomal-like compartment as part of antigen presentation (Polson, 2007).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD79a antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-CD79A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800688) Mouse IgG1 OTI5E2 Purified Hu P
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD79a (202-216) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil (20X) stained with CD79a Antibody (Clone HM47/A9). Mouse IgG1 HM47/A9 Supernatant Bov, Hu, Mky, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
1.0 ml / €360.00
  Acris Antibodies GmbH

CD79a (202-216) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil (20X) stained with CD79a Antibody (Clone HM47/A9). Mouse IgG1 HM47/A9 Supernatant Bov, Hu, Mky, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.5 ml / €290.00
  Acris Antibodies GmbH

CD79a (202-216) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil (20X) stained with CD79a Antibody (Clone HM47/A9). Mouse IgG1 HM47/A9 Supernatant Bov, Hu, Mky, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.1 ml / €150.00
  Acris Antibodies GmbH

CD79a (N-term) antibody

AM11117PU CD79a antibody staining of Human B cell lymphoma. Rabbit SP18 Supernatant Bov, Chk, Eq, GP, Hu, Mky, Por, Rb, Rt F, P
1 ml / €590.00
  Acris Antibodies GmbH

CD79a (N-term) antibody

AM11117PU CD79a antibody staining of Human B cell lymphoma. Rabbit SP18 Supernatant Bov, Chk, Eq, GP, Hu, Mky, Por, Rb, Rt F, P

Regular Price: 0.1 ml / €160.00

Special Price: 0.1 ml / €112.00

  Acris Antibodies GmbH

CD79a (N-term) antibody

AM11117PU CD79a antibody staining of Human B cell lymphoma. Rabbit SP18 Supernatant Bov, Chk, Eq, GP, Hu, Mky, Por, Rb, Rt F, P

Regular Price: 25 µl / €80.00

Special Price: 25 µl / €56.00

  Acris Antibodies GmbH

CD79a antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil (20X) stained with CD79a Antibody Cat.-No AM50196PU (Clone SPM549). Mouse IgG1 SPM549 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

CD79a antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil (20X) stained with CD79a Antibody Cat.-No AM50196PU (Clone SPM549). Mouse IgG1 SPM549 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD79a antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil (20X) stained with CD79a Antibody Cat.-No AM50196PU (Clone SPM549). Mouse IgG1 SPM549 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

CD79a antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil (20X) stained with CD79a Antibody Cat.-No AM50197PU (Clone SPM550). Mouse IgG1 SPM550 Purified Bov, Hu, Mky, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

CD79a antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil (20X) stained with CD79a Antibody Cat.-No AM50197PU (Clone SPM550). Mouse IgG1 SPM550 Purified Bov, Hu, Mky, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD79a antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil (20X) stained with CD79a Antibody Cat.-No AM50197PU (Clone SPM550). Mouse IgG1 SPM550 Purified Bov, Hu, Mky, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

CD79a (N-term) antibody

Human tonsil stained with Anti-CD79a antibody Rabbit Purified Hu P, WB
0.5 ml / €300.00
  Acris Antibodies GmbH

CD79a (N-term) antibody

Human tonsil stained with Anti-CD79a antibody Rabbit Purified Hu P, WB
1 ml / €410.00
  Acris Antibodies GmbH

CD79a (N-term) antibody

Human tonsil stained with Anti-CD79a antibody Rabbit Purified Hu P, WB
0.1 ml / €170.00
  Acris Antibodies GmbH

CD79a antibody

Western blot analysis of extracts from HuvEc cells, using CD79A antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD79a antibody

Immunohistochemistry staining of Paraffin Tonsil tissue by CD79a antibody (dilution: 1:100 - 1:500; visualization of staining: Membranous) Mouse IgG1 JCB117 Purified Hu P
1 ml / €390.00
  OriGene Technologies, Inc.

CD79a antibody

Host: Rabbit; Target Name: CD79A; Sample Tissue: HT1080 Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu, Rt, Ye WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD79a antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-CD79A mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA803156) Mouse IgG1 OTI3D3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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