CD8 antibody

Principal name

CD8 antibody

Alternative names for CD8 antibody

CD8 alpha chain, CD8A, MAL, T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain

SwissProt ID

P01731 (Mouse), P01732 (Human), P07725 (Rat), P31783 (Bovin), P33706 (Canfa), P41688 (Felca), Q0R4I4 (Chick), Q6R2U9 (Pig)

Gene ID

24930 (Cd8a), 12525, 925 (CD8A), 281060, 493799, 403157, 396627

Available reactivities

Rt (Rat), Ms (Mouse), Hu (Human), Mky (Monkey), GP (Guinea Pig), Sh (Sheep), Can (Canine), Fe (Feline), Av (Birds), Por (Porcine), Bov (Bovine), Gt (Goat), Chk (Chicken), Dky (Donkey), Eq (Equine)

Available hosts

Mouse, Rat, Rabbit

Available applications

Frozen Sections (C), Flow Cytometry (F), Cytotoxicity Assay (CT), Paraffin Sections (P), Immunoprecipitation (IP), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Neutralisation (NEUT), ELISA (detection) (E(detection)), Functional assay (FN), Microcytotoxicity (MC)

Background of CD8 antibody

The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. TCR is a heterodimer composed of either α and β or γ and δ chains. The vast majority of circulating T cells (95%) express the α/β heterodimer while roughly 2-5% express the γ/δ heterodimer.  
CD3 chains and the CD4 or CD8 coreceptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8. T helper cells express CD4 proteins and T cytotoxic cells display CD8. CD4 is also expressed on cortical cells, mature medullary thymocytes, microglial cells and dendritic cells. CD4, also designated T4 and Leu 3, is a 55 kDa membrane glycoprotein that contains four extracellular immunoglobinlike domains. The TCR, in association with CD4, can bind class II MHC molecules presented by the antigen-presenting cells. The CD4 protein functions by increasing the avidity of the interaction between the TCR and an antigen-class II MHC complex.

General readings

1. Zarkesh-Esfahani, H. et al. (2001) High-dose Leptin activates human leukocytes via receptor expression on monocytes. J. Immunol. 167: 4593 - 4599.
2. Manninen, A. et al. (2002) HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells. J. Exp.Med. 195 (8): 1023 -1032.
3. Parnes, J.R. (1989) Molecular biology and function of CD4 and CD8. Adv. Immunol. 44: 265-311.
4. Kap, Y.S. et al. (2009) A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. J Histochem Cytochem. 57: 1159-67.
5. Hovden, A.O. et al. (2011) Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. BMC Immunol. 12: 2.
6. Nelson, M. et al. (2010) Characterization of lethal inhalational infection with Francisella tularensis in the common marmoset (Callithrix jacchus). J Med Microbiol. 59: 1107-13.
7. Gibbings, D.J. et al. (2007) CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses.
BMC Immunol. 8: 12.
8. Junker, A. et al. (2007) Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain. 130: 2789-99.
9. Held, K. et al. (2011) Expression of HSV-1 encoded miRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates. J Virol. Jul 27. [Epub ahead of print]

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD8 antibody

CD8 Mouse IgG1 17D8 Purified Hu F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD8 antibody

Figure 1. Peripheral blood lymphocytes stained with AM05173RP-N antibody. Mouse IgG1 17D8 PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

CD8 antibody


Bovine lymph node stained with Mouse anti Bovine CD8 Antibody Cat.-No AM05901PU-S (Clone CC63). 10x. Image courtesy of Dr. J.B. Silvan, Moredun Research Institute, Roslin, UK
Mouse IgG2a CC63 Purified Bov, Gt, Sh C, F, ICC/IF, IP, P
0.1 mg / €330.00
  Acris Antibodies GmbH

CD8 antibody

Surface staining of human peripheral blood lymphocytes using anti-human CD8 PE (SM3102R). Mouse IgG2a MEM-31 PerCP Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD8 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-CD8A Rabbit Polyclonal antibody. (TA590306) Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD8 (C-term) antibody

Human Spleen stained with anti-CD8 antibody Rabbit IgG SP16 Supernatant Hu P
1 ml / €630.00
  Acris Antibodies GmbH

CD8 (C-term) antibody

Human Spleen stained with anti-CD8 antibody Rabbit IgG SP16 Supernatant Hu P
0.1 ml / €290.00
  Acris Antibodies GmbH

CD8 antibody

Immunoperoxidase staining of a mouse lymph node cryosection with Rat anti Mouse CD8 antibody, clone YTS169.4 Cat.-No CL007P) followed by horseradish peroxidase conjugated Goat anti Rat IgG antibody. Medium power. Rat IgG2b YTS169.4 Purified Ms C, F
0.25 mg / €350.00
  Acris Antibodies GmbH

CD8 antibody

Surface staining of human peripheral blood lymphocytes using anti-human CD8 (clone MEM-31) PE Mouse IgG2a MEM-31 APC Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD8 antibody

Surface staining of human peripheral blood lymphocytes using anti-human CD8 (clone MEM-31) PE Mouse IgG2a MEM-31 Biotin Hu F
0.1 mg / €260.00
  Acris Antibodies GmbH

CD8 antibody

Surface staining of human peripheral blood cells with anti-human CD8 (MEM-31) FITC. Mouse IgG2a MEM-31 FITC Hu F
100 Tests / €260.00
  Acris Antibodies GmbH

CD8 antibody

Surface staining of human peripheral blood lymphocytes using anti-human CD8 (clone MEM-31) PE Mouse IgG2a MEM-31 Purified Hu F, IP
0.1 mg / €210.00
  Acris Antibodies GmbH

CD8 antibody

Surface staining of human peripheral blood lymphocytes using anti-human CD8 (clone MEM-31) PE Mouse IgG2a MEM-31 PE Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD8 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 μm) stained with anti-CD8 antibody (DB 085) shows strong membranous immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P17-V Aff - Purified Hu C, P
0.1 ml / €310.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD8 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 μm) stained with anti-CD8 antibody (DB 085) shows strong membranous immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P17-V Aff - Purified Hu C, P
0.2 ml / €420.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD8 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 μm) stained with anti-CD8 antibody (DB 085) shows strong membranous immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P17-V Aff - Purified Hu C, P
0.5 ml / €540.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD8 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil tissue (4 μm) stained with anti-CD8 antibody (DB 085) shows strong membranous immunostaining of T-lymphocytes. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P17-V Aff - Purified Hu C, P
1 ml / €840.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD8 (N-term) antibody

Anti-CD8 (DB 086) Western blot of CD8: lane 1 – 100 ng; lane 2 – 200 ng; lane 3 – 500 ng of recombinant human CD8 (N-term GST human CD8, aa 1 – 236; Novus Biologicals, H00000925-P01). Rabbit IgG S23-D Aff - Purified Hu C, E, ICC/IF, IP, P, WB
0.1 ml / €510.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD8 (N-term) antibody

Anti-CD8 (DB 086) Western blot of CD8: lane 1 – 100 ng; lane 2 – 200 ng; lane 3 – 500 ng of recombinant human CD8 (N-term GST human CD8, aa 1 – 236; Novus Biologicals, H00000925-P01). Rabbit IgG S23-D Aff - Purified Hu C, E, ICC/IF, IP, P, WB
50 µl / €340.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD8 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with CD8 Antibody Cat.-No AM10073PU (Clone C8/144B). Note Cell surface staining. Mouse IgG1 C8/144B Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

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