CD8 beta antibody

Principal name

CD8 beta antibody

Alternative names for CD8 beta antibody

CD8B, CD8B1, T-cell surface glycoprotein CD8 beta chain

SwissProt ID

P05541 (Rat), P10300 (Mouse), P10966 (Human), P79336 (Felca), Q90769 (Chick)

Gene ID

24931 (Cd8b), 493948 (CD8B), 12526 (Cd8b1), 926, 396175

Available reactivities

Rt (Rat), Fe (Feline), Mky (Monkey), Ms (Mouse), Hu (Human), Can (Canine), Bov (Bovine), Gt (Goat), Sh (Sheep), Chk (Chicken), Av (Birds), Duck

Available hosts

Mouse, Rat, Rabbit

Available applications

Flow Cytometry (F), Enzyme Immunoassay (E), Cytotoxicity Assay (CT), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Frozen Sections (C), Functional assay (FN), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD8 beta antibody

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8B is the CD8 beta chain isoforms.The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.

General readings

1. Terry, L.A. et al. (1990) Differential expression and regulation of the human CD8 alpha and CD8 beta chains. Tissue Antigens 35: 82-91.
2. DiSanto, J.P. et al. (1991) Generation of anti-human CD8 beta specific antibodies using transfectants expressing mixed species CD8 heterodimers. J. Immunol. Methods 141: 123-131.
3. Yoshino, N. et al. (2000) Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of Cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp. Anim. 49: 97-110.
4. Fry, T.J. et al. (2002) IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates.
Blood. 101: 2294-9.
5. Schmitz, J.E. et al (1998) Expression of the CD8alpha beta-heterodimer on CD8(+) T lymphocytes in peripheral blood lymphocytes of human immunodeficiency virus- and human immunodeficiency virus+ individuals.
Blood. 92: 198-206.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD8 beta antibody

CD8 beta Mouse IgG2a 2ST8.5H7 Purified Hu, Mky F, IP, WB
0.2 mg / €430.00
  Acris Antibodies GmbH

CD8 beta antibody

Western blot analysis of CD8B expression in Jurkat cells Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD8 beta antibody

CD8 beta Rat IgG2b YTS156.7.7 PE Ms F
0.5 ml / €310.00
  Acris Antibodies GmbH

CD8 beta antibody

CD8 beta Mouse IgG2a EP42 Biotin Chk F
0.5 mg / €410.00
  Acris Antibodies GmbH

CD8 beta antibody

Immunofluorescent Staining: Chicken IEL were double stained with Mouse anti-Chicken CD8b-FITC and Mouse anti-Chicken CD8b-RPE. Small lymphocytes were then gated and analyzed on a FACScan(TM) flow cytometer (BDIS, San Jose, CA). Amount Used: 1 µg/10e6 cells. Mouse IgG2a EP42 FITC Chk F
0.5 mg / €450.00
  Acris Antibodies GmbH

CD8 beta antibody

CD8 beta Mouse IgG2a EP42 Purified Chk C, F, IP
0.5 mg / €340.00
  Acris Antibodies GmbH

CD8 beta antibody

CD8 beta Mouse IgG2a EP42 PE Chk F
0.1 mg / €320.00
  Acris Antibodies GmbH

CD8 beta (N-term) antibody

Western blot analysis of anti-CD8B1 Pab (AP11413PU-N) in K562 cell line lysates (35 µg/lane). CD8B1 (arrow) was detected using the purified Pab (1:60 dilution). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD8 beta antibody

Tissue Distribution by Cytotoxicity Analysis Mouse IgM F9(1) Ascites Ms CT
0.5 ml / €500.00
  Acris Antibodies GmbH

CD8 beta antibody

CD8 beta Mouse IgM F9(1) Supernatant Ms CT
1 ml / €210.00
  Acris Antibodies GmbH

CD8 beta antibody

Flow Cytometry - Representative histogram - Cell Source: Spleen - Percentage of cells stained above control: 9.2% Rat IgG2a CT-CD8b Biotin Ms F
0.1 mg / €310.00
  Acris Antibodies GmbH

CD8 beta antibody

Flow Cytometry - Cell Source: Spleen - Percentage of cells stained above control: 9.2% Rat IgG2a CT-CD8b Biotin Ms F
0.3 mg / €550.00
  Acris Antibodies GmbH

CD8 beta antibody

CD8 beta Rat IgG2a CT-CD8b FITC Ms F
0.1 mg / €310.00
  Acris Antibodies GmbH

CD8 beta antibody

CD8 beta Rat IgG2a CT-CD8b FITC Ms F
0.3 mg / €550.00
  Acris Antibodies GmbH

CD8 beta antibody

Cell Source: Balb/c thymus labelled with CL012P including isotypic control. Percentage of cells stained above control: 90.9% Rat IgG2a CT-CD8b Purified Ms F
0.2 mg / €380.00
  Acris Antibodies GmbH

CD8 beta antibody

CD8 beta Rat IgG2a CT-CD8b PE Ms F
50 µg / €330.00
  Acris Antibodies GmbH

CD8 beta antibody

CD8 beta Rat IgG2a CT-CD8b PE Ms F
0.3 mg / €820.00
  Acris Antibodies GmbH

CD8 beta antibody

Cell Source: Thymus. 
Percentage of cells stained above control: 90.0%. 
Representative Histogram Mouse IgG1 3.4.1 Biotin Rt F
0.1 mg / €280.00
  Acris Antibodies GmbH

CD8 beta antibody

Cell Source: Thymus. 
Percentage of cells stained above control: 90.0%. 
Representative Histogram Mouse IgG1 3.4.1 Biotin Rt F
0.5 mg / €470.00
  Acris Antibodies GmbH

CD8 beta antibody

CD8 beta Mouse IgG1 341 FITC Rt F
0.1 mg / €430.00
  Acris Antibodies GmbH

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