CD88 / C5R1 antibody

Principal name

CD88 / C5R1 antibody

Alternative names for CD88 / C5R1 antibody

C5a-R, C5aR, C5AR1, Complement Component 5a Receptor 1, C5a anaphylatoxin chemotactic receptor

SwissProt ID

O70129 (Cavpo), P21730 (Human), P30992 (Canfa), P30993 (Mouse), P97520 (Rat), Q9TUE1 (Rabit)

Gene ID

728 (C5AR1), 113959 (C5ar1), 12273

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human), Mky (Monkey), Prim (Primate), Bov (Bovine), Rb (Rabbit), Ft (Ferret), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Sh (Sheep)

Available hosts

Chicken, Rabbit, Mouse, Rat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), Functional assay (FN), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Neutralisation (NEUT)

Background of CD88 / C5R1 antibody

The inte immune system identifies pathogens by recognizing known elements. This response ultimately leads to the production of proinflammatory substances and the activation of phagocytic neutrophils and macrophages. Activation of the complement system is an important initial even in the response against pathogens. This system includes some thirty different proteins that act together to form a complex. C5a is one of the most potent inflammatory peptides generated by complement activation. This peptide has many functions such as acting as a chemoattractant for neutrophils. C5a acts as a vasodilator and activates the coagulation pathway just to me a few. C5a exerts its numerous actions by binding to C5aR and C5L2. C5aR belongs to the superfamily of G-protein coupled receptors (GPCRs). Like all members, C5aR has seven transmembrane domains, an extracellular N-terminus and an intracellular C-termil tail. C5aR can form homodimers or heteromer with CCR5, chemokine receptor, for example. Activation of C5aR by C5a binding causes Ca2+ mobilization. C5aR expression is detected in neutrophils, eisinophils, basophils and monocytes. The receptor is also expressed in lung and liver. Blocking C5aR by peptides or organic small molecules is in the pipeline for treating chronic inflammatory disorders/diseases like arthritis, inflammatory bowel disease and lung/liver injuries.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD88 / C5R1 antibody

Western blot analysis of K562 (lanes 1 and 4), MEG-01 (lanes 2 and 5) and THP-1 (lanes 3 and 6) cell lysates: 1-3. Anti-C5a Anaphylatoxin Receptor (extracellular) antibody , (1:200). 4-6. Anti-C5a Anaphylatoxin Receptor (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CD88 / C5R1 (Internal) antibody

Anti-C5AR1 / CD88 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Hu, Mky, Prim P
50 µg / €379.00
  OriGene Technologies, Inc.

CD88 / C5R1 antibody

WB Suggested Anti-C5AR1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD88 / C5R1 antibody

CD88 / C5R1 Mouse IgG1 32-G1 Purified Hu E, ICC/IF, WB
0.1 mg / €480.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

CD88 / C5R1 Rat IgG2a 10/92 Biotin Ms F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

Staining of mouse peripheral blood granulocytes with Rat anti Mouse CD88 Cat.-No AM01269PU (Clone 10/92). Rat IgG2a 10/92 Purified Ms C, F
0.25 mg / €390.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

Staining of mouse peripheral blood granulocytes with Rat anti Mouse CD88 Cat.-No AM01269PU (Clone 10/92). Rat IgG2a 10/92 Purified Ms C, F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

CD88 / C5R1 Rat IgG2a 10/92 PE Ms F
25 Tests / €210.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

CD88 / C5R1 Rat IgG2b 20/70 Low Endotoxin Ms F
0.5 mg / €540.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

CD88 / C5R1 Rat IgG2b 20/70 Purified Ms F
0.25 mg / €400.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

CD88 / C5R1 Rat IgG2b 20/70 Purified Ms F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

CD88 / C5R1 Rat IgG2b 20/70 Purified Ms F
25 µg / €170.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

CD88 / C5R1 Rat IgG2b 20/70 PE Ms F
100 Tests / €290.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

CD88 / C5R1 Rat IgG2b 20/70 PE Ms F
25 Tests / €210.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

AM20489PU-N C5AR1 Antibody staining of Formalin-Fixed, Paraffin-Embedded Human Placenta at 10 µg/ml after heat-induced antigen retrieval. Mouse IgG2a 3H1738 Purified Hu, Rb E, F, FN, NEUT, P
50 µg / €470.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

Human placenta paraffin sections stained with AM26723PU-N. Mouse IgG2a 3C6 Purified Hu P
0.2 mg / €390.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

CD88 / C5R1 Rat IgG2a 8D6 Biotin Hu F
0.1 mg / €290.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

CD88 / C5R1 Rat IgG2a 8D6 FITC Hu F
0.1 mg / €300.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

CD88 / C5R1 Rat IgG2a 8D6 Purified Hu F
0.25 mg / €410.00
  Acris Antibodies GmbH

CD88 / C5R1 antibody

CD88 / C5R1 Rat IgG2a 8D6 PE Hu F
50 µg / €270.00
  Acris Antibodies GmbH

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