CD98 / SLC3A2 antibody

Principal name

CD98 / SLC3A2 antibody

Alternative names for CD98 / SLC3A2 antibody

4F2hc, MDU1, 4F2 cell-surface antigen heavy chain, Lymphocyte activation antigen 4F2 large subunit, 4F2 heavy chain antigen

SwissProt ID

P08195 (Human), P10852 (Mouse), Q794F9 (Rat), Q7YQK3 (Rabit)

Gene ID

6520 (SLC3A2), 17254 (Slc3a2), 50567

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse, Rat, Hamster

Available applications

Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), EPair for Elisa (EPair), ELISA (detection) (E(detection)), Immunohistochemistry (IHC)

Background of CD98 / SLC3A2 antibody

CD98 is a type II transmembrane glycoprotein which associates with members of the L type amino transporter family to form a heterodimeric complex CD98 constitutes the heavy chain of the complex and is required for the surface expression and basolateral localization of the amino acid transporter complex in polarized epithelial cells. The CD98 heavy chain also interacts with beta 1 integrins and regulates their activation through the cytoplasmic domains and transmembrane regions. Studies suggest that overexpression of CD98 may contribute to cell growth and survival by regulating integrin signalling, and therefore may play an important role in tumorigenesis. The tissue distribution of this antigen is broad. Monocytes express high levels of CD98 antigen. Peripheral blood T and B cells, as well as NK cells and granulocytes express low levels of CD98 antigen. Activation of T cells and NK cells leads to upregulation of this antigen.

General readings

Liu X, Charrier L, Gewirtz A, Sitaraman S, Merlin D: CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia. J Biol Chem. 2003 Jun 27;278(26):23672-7.
Cho JY, Skubitz KM, Katz DR, Chain BM: CD98-dependent homotypic aggregation is associated with translocation of protein kinase Cdelta and activation of mitogen-activated protein kinases. Exp Cell Res. 2003 May 15;286(1):1-11.
Cai S, Bulus N, Fonseca-Siesser PM, Chen D, Hanks SK, Pozzi A, Zent R: CD98 modulates integrin beta1 function in polarized epithelial cells. J Cell Sci. 2005 Mar 1;118(Pt 5):889-99.
Dalton P, Christian HC, Redman CW, Sargent IL, Boyd CA: Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line. Biochim Biophys Acta. 2007 Mar;1768(3):401-10.
Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD98 / SLC3A2 antibody

Immunohistochemistry: SM1173P/PT CD98 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Adrenal at 15 µg/ml followed by biotinylated anti-Mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 44D7 Purified Hu C, F, IP, P
0.2 mg / €430.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

Immunohistochemistry: SM1173P/PT CD98 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Adrenal at 15 µg/ml followed by biotinylated anti-Mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 44D7 Purified Hu C, F, IP, P
25 µg / €180.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

Sample (30 ug of whole cell lysate). A: Molt-4 . 7.5% SDS PAGE. TA308364 diluted at 1:1000. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD98 / SLC3A2 antibody

Anti-SLC3A2 antibody IHC of human, testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml. Mouse IgG1 44D7 Purified Hu C, F, IP
50 µg / €345.00
  OriGene Technologies, Inc.

CD98 / SLC3A2 antibody

Staining of BALB/c splenocytes with 0.125 ug of Rat IgG2a kappa Isotype Control Purified (open histogram) or 0.125 ug of Anti-Mouse CD98 Purified (filled histogram) followed by Anti-Rat IgG FITC .  Total viable cells were used for analysis. Rat RL388 Purified Ms F, IP
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD98 / SLC3A2 antibody

Western blot analysis of extracts of various cell lines, using SLC3A2 antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD98 / SLC3A2 antibody

Staining of mouse peripheral blood lymphocytes with RAT ANTI MOUSE CD98(AM05637PU-L). Rat IgG1 H202-529.4.1.4 Purified Ms F
0.25 mg / €390.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

Staining of mouse peripheral blood lymphocytes with RAT ANTI MOUSE CD98(AM05637PU-N). Rat IgG1 H202-529.4.1.4 Purified Ms F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

Formalin-Fixed Paraffin-Embedded Human Adrenal medulla stained with CD98 antibody Cat.-No AM06069PU-N Mouse IgG1 n.a Purified Hu C, F, IP, P
50 µg / €470.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

Western blot analysis of mouse CD98 expression in P3U1 cells using AM26481AF-N. Hamster IgG 10.7 Azide Free Ms IP, P, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

Flow cytometric analysis of mouse CD98 expression on P3U1 cells. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26482AF-N to the cells. Hamster IgG 10.3 Azide Free Ms F, IP
0.1 mg / €300.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

Flow cytometric analysis of Mouse CD98 expression on P3U1 cells. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26482FC-N to the cells. Hamster IgG 10.3 FITC Ms F
50 µg / €330.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

Flow cytometric analysis of mouse CD98 antigen expression on P3U1 cells. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26483AF-N to the cells. Hamster IgG 14.37 Azide Free Ms F, IP
0.1 ml / €300.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

Flow cytometric an alysis of CD98hc expression on HPB-ALL. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26553AF-N to the cells. Mouse IgG2a YUK14 Azide Free Hu F
0.1 mg / €340.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

Flow cytometric analysis of CD98hc expression on human lymphocyte (R1), monocyte (R2) and granulocyte (R3) using AM26553FC-S. Open histograms indicate the reaction of isotypic control to the cells. Shaded histograms indicate the reaction of AM26553FC-S to the cells. Mouse IgG2a YUK14 FITC Hu F
0.1 ml / €390.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

CD98 / SLC3A2 Mouse IgM IPO-T10 Supernatant Hu C, F, ICC/IF
1.0 ml / €360.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

CD98 / SLC3A2 Mouse IgM IPO-T10 Supernatant Hu C, F, ICC/IF
0.5 ml / €290.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

CD98 / SLC3A2 Mouse IgM IPO-T10 Supernatant Hu C, F, ICC/IF
0.1 ml / €150.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

CD98 / SLC3A2 Mouse IgG1 UM7F8 Purified Hu C, F, ICC/IF, IP, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

CD98 / SLC3A2 antibody

CD98 / SLC3A2 Mouse IgG1 UM7F8 Purified Hu C, F, ICC/IF, IP, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

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