CDC14A antibody

Principal name

CDC14A antibody

Alternative names for CDC14A antibody

Dual specificity protein phosphatase CDC14A, CDC14 cell division cycle 14 homolog A

SwissProt ID

Q6GQT0 (Mouse), Q9UNH5 (Human)

Gene ID

8556 (CDC14A)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of CDC14A antibody

Overproduction of hCdc14A leads to progressive cell death, accompanied by accumulation of pre-G1 DNA fragments and gradual elimination of cells at the G2/M transition. In 50% of the mitotic cells, multipolar mitotic spindles and misaggregated chromosomes are found. hCdc14A localizes to the centrosomes at the cell-cycle interphase stage. When the cell enters mitosis, this localization disappears suggesting that hCdc14A dissociates from the centrosomes at the G2/M transition. hCdc14A localizes to interphase centrosomes, but not to mitotic centrosomes, while hCdc14B localizes to the interphase nucleolus. Thus each isoform regulates separate cell cycle events. Cdc14A may affect cell cycle progression by its ability to dephosphorylate p53 at Ser315. This phosphatase activity is mediated by the interaction between the N-terminus of hCdc14A and the C-terminus of p53.

General readings

General / background references:Mailand N et al. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nat Cell Biol 4:317-22 (2002). PubMed PMID: 11901424
Kaiser BK et al. Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. Mol Biol Cell 13:2289-300 (2002). PubMed PMID: 12134069
Li L et al. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. J Biol Chem 272:29403-6 (1997). PubMed PMID: 9367992

11 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CDC14A antibody

Western blot analysis of extracts from HeLa cells, using CC14A antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDC14A antibody

CDC14A Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

CDC14A antibody

CDC14A Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CDC14A antibody

Western Blot analysis of CDC14A expression in transfected 293T cell line by CDC14A monoclonal antibody (M01), clone 2C12.

Lane 1: CDC14A transfected lysate(66.6 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2b 2C12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CDC14A antibody

Immunofluorescence of monoclonal antibody to CDC14A on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG2a 1F11 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CDC14A antibody

Western Blot: Cdc14A Antibody (NB120-10536) - WB analysis of A431 human cell extract was separated on SDS-PAGE and probed with Monoclonal Anti-CDC14A (NB120-10536) at 1 mg/ml. The antibody was developed using ECL substrate. Mouse IgG1 DCS-291 Purified Hu E, ICC/IF, IP, WB
50 µl / €340.00
  Novus Biologicals Inc.

CDC14A antibody

Immunohistochemistry-Paraffin: Cdc14A Antibody [NBP1-84573] - Immunohistochemical staining of human duodenum shows strong nuclear and cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CDC14A

CDC14A Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

CDC14A

CDC14A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CDC14A

CDC14A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CDC14A overexpression lysate

CDC14A overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

11 Item(s)

per page
  • LinkedIn