CDK2 antibody

Principal name

CDK2 antibody

Alternative names for CDK2 antibody

p33 protein kinase, Cell division protein kinase 2,Cyclin dependent kinase 2

SwissProt ID

O55076 (Crigr), P23437 (Xenla), P24941 (Human), P97377 (Mouse), Q5E9Y0 (Bovin), Q63699 (Rat)

Gene ID

1017 (CDK2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Rb (Rabbit), Ze (Zebrafish), African clawed frog, Xen (Xenopus), Por (Porcine), Sh (Sheep), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Flow Cytometry (F), Whole mount Immunohistochemistry (IHC-wm)

Background of CDK2 antibody

p33cdk2 associates with cyclin A in human cells. Kinase activity associated with cyclin A-cdc2 is found only in G2-phase. Cdk2 also complexes with cyclins E, D1, and D3. Cyclin E-cdk2 kinase is active in the G1- and S-phases of the cell cycle and is important (as does cyclin A-cdk2) for the progression from G1-to S-phase. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase. 
Distribution: Nuclear protein, predicted molecular weight 34 kD.
Function: Involved in the control of the cell cycle.
Interaction: Cyclins A, B1, B3, D, or E.

General readings

General / background references:Goodger NM et al. Cell cycle regulatory proteins--an overview with relevance to oral cancer. Oral Oncol 33:61-73 (1997). PubMed PMID: 9231162
Strausfeld UP et al. Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts. J Cell Sci 109 ( Pt 6):1555-63 (1996). PubMed PMID: 8799842
Baptist M et al. Expression and subcellular localization of CDK2 and cdc2 kinases and their common partner cyclin A in thyroid epithelial cells: comparison of cyclic AMP-dependent and -independent cell cycles. J Cell Physiol 166:256-73 (1996). PubMed PMID: 8591985
Strausfeld UP et al. Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases. Curr Biol 4:876-83 (1994). PubMed PMID: 7850420

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CDK1 / CDK2 pThr14 antibody

Western blot analysis of extracts from HepG2 cells treated with Forskolin using Phospho-CDK1/CDC2 (Thr14) antibody AP55944PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

CDK1 / CDK2 pThr14 antibody

Western blot analysis of extracts from HepG2 cells treated with Forskolin using Phospho-CDK1/CDC2 (Thr14) antibody AP55944PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €270.00
  Acris Antibodies GmbH

CDK2 antibody

Immunofluorescent staining of HeLa cells using anti-CDK2 mouse monoclonal antibody (TA502807). Mouse IgG2a OTI1C4 Purified Hu, Mky F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDK2 antibody

Anti-CDK2 mouse monoclonal antibody (TA502808) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CDK2(RC200494). Mouse IgG1 OTI2F10 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDK2 antibody

Immunofluorescent staining of HeLa cells using anti-CDK2 mouse monoclonal antibody (TA502832). Mouse IgG2a OTI1H5 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDK2 antibody

Anti-CDK2 mouse monoclonal antibody (TA502833) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CDK2(RC200494). Mouse IgG2b OTI4B4 Purified Hu, Mky F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDK2 antibody

Anti-CDK2 mouse monoclonal antibody (TA502893) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CDK2(RC200494). Mouse IgG2a OTI4D3 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDK2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-CDK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502915) Mouse IgG2a OTI2A5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDK2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-CDK2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502935) Mouse IgG2a OTI2D9 Purified Can, Hu, Mky, Rt F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CDK2 antibody

Anti-CDK2 mouse monoclonal antibody (TA502936) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CDK2(RC200494). Mouse IgG2b OTI6H2 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDK2 antibody

Immunofluorescent staining of HeLa cells using anti-CDK2 mouse monoclonal antibody (TA502943). Mouse IgG2a OTI1A8 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDK2 antibody

Immunohistochemical analysis of paraffin-embedded colon cancer (left) and cervical cancer (right) tissues using CDK2 antibody Cat.-No AM06741PU-N with DAB staining. Mouse IgG1 1A6 Purified Hu, Ms E, F, ICC/IF, P, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

CDK2 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between CDK2 and PCNA. Mahlavu cells were stained with anti-CDK2 rabbit purified polyclonal 1:1200 and anti-PCNA mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CDK2 antibody

Western blot analysis of CDK2 over-expressed 293 cell line, cotransfected with CDK2 Validated Chimera RNAi ( Cat # H00001017-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with CDK2 monoclonal antibody (M02) clone 2E8 (Cat # H00001017-M02 ). GAPDH ( 36.1 kDa ) used as specificity and loading control. Mouse IgG1 2E8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CDK2 (C-term) antibody

Human tonsil stained with anti-Cdk2 antibody Rabbit IgG SP80 Purified Hu P, WB
0.5 ml / €510.00
  Acris Antibodies GmbH

CDK2 (C-term) antibody

Human tonsil stained with anti-Cdk2 antibody Rabbit IgG SP80 Purified Hu P, WB
1 ml / €730.00
  Acris Antibodies GmbH

CDK2 (C-term) antibody

Human tonsil stained with anti-Cdk2 antibody Rabbit IgG SP80 Purified Hu P, WB
0.1 ml / €290.00
  Acris Antibodies GmbH

CDK2 (C-term) antibody

Human tonsil stained with anti-Cdk2 antibody Rabbit Purified Hu P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

CDK2 (C-term) antibody

Human tonsil stained with anti-Cdk2 antibody Rabbit Purified Hu P, WB
1 ml / €520.00
  Acris Antibodies GmbH

CDK2 (C-term) antibody

Human tonsil stained with anti-Cdk2 antibody Rabbit Purified Hu P, WB
0.1 ml / €190.00
  Acris Antibodies GmbH

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