CDK5 antibody

Principal name

CDK5 antibody

Alternative names for CDK5 antibody

PSSALRE, TPKII catalytic subunit, Cell division protein kinase 5,Cyclin-dependent kinase 5, Tau protein kinase II catalytic subunit, Serine/threonine-protein kinase PSSALRE

SwissProt ID

P49615 (Mouse), P51166 (Xenla), Q00535 (Human), Q02399 (Bovin), Q03114 (Rat)

Gene ID

1020 (CDK5), 140908 (Cdk5)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), Dros (Drosophila), African clawed frog, Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), Paraffin Sections (P), Frozen Sections (C), ELISA (detection) (E(detection)), Whole mount Immunohistochemistry (IHC-wm)

Background of CDK5 antibody

Cdks (cyclin-dependent kises) are heteromeric serine/threonine kises that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces transcription of genes including cyclins A and E, D polymerase and thymidine kise. Cdk4-cyclin E complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation of mitosis. Cdks are constitutively expressed and are regulated by several kises and phosphastases, including Wee1, CDK-activating kise and Cdc25 phosphatase. In addition, cyclin expression is induced by molecular sigls at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability. Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic strategies that block Cdk activity are unlikely to selectively target tumor cells.

General readings

Demetrick DJ. et al. (1994) Cytogenet Cell Genet. 66:72-74.Meyerson M. et al. (1992) EMBO J. 11:2909-2917.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CDK5 antibody

Immunofluorescent staining of HT29 cells using anti-CDK5 mouse monoclonal antibody (TA500397). Mouse IgG1 OTI2H6 Purified Can, Hu F, ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CDK5 antibody

Immunohistochemical analysis of paraffin-embedded cerebellum tissues (left) and brain tissues (right) using CDK5 mouse mAb with DAB staining. Mouse IgG1 4E4 Ascites Hu, Mky, Rt E, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

CDK5 antibody

Immunofluorescence: Cdk5 Antibody (2H6) [NBP1-47692] - Anti-CDK5 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CDK5. Mouse 2H6 Aff - Purified Can, Hu F, ICC/IF, WB
0.1 ml / €620.00
  Novus Biologicals Inc.

CDK5 antibody

Western blot of rat caudate lysate showing specific immunolabeling of the ~ 28k Cdk5 protein. Mouse IgG 1H3 Aff - Purified Hu, Ms, Rt C, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDK5 antibody

Western blot analysis of extracts from Jurkat cells and HepG2 cells, using CDK5 (Ab-15) antibodyThe lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDK5 antibody

anti-CDK5 antibody was diluted 1:500 to detect CDK5 in human brain cortex tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. Rabbit Serum Hu, Ms, Rt E, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDK5 antibody

Western blot analysis of Jurkat and NIH/3T3 cell using TA323961(CDK5 Antibody) at dilution 1/300 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDK5 antibody

Western blot analysis of Human fetal brain and colon cancer tissue using TA323962(CDK5 Antibody) at dilution 1/150 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDK5 antibody

Western blot analysis of CDK5 expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDK5 antibody

Western blot analysis of extracts of various cell lines, using CDK5 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CDK5 antibody

Western blot detection of CDK5(N-terminus) in 3T3,Hela,PC-12,COS7,Jurkat and K562 lysates using Cdk5 mouse mAb (1:500 diluted).Predicted band size: 36KDa.Observed band size: 36KDa.Exposure time:5min. Mouse IgG1 2E8-F9-B7-C11 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDK5 antibody

Immunohistochemistry (IHC) analyzes of Cdk5 antibody (Cat.-No.: AP01458PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CDK5 (C-term) antibody

CDK5 Rabbit IgG Serum Hu, Ms, Rt E, IP, WB
50 µl / €320.00
  Acris Antibodies GmbH

CDK5 (C-term) antibody

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Hu, Ms, Rt E, IP, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CDK5 pTyr15 antibody

Western blot analysis of extracts from COS7 cells treated with EGF using Phospho-CDK5 (Tyr15) antibody AP55874PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

CDK5 pTyr15 antibody

Western blot analysis of extracts from COS7 cells treated with EGF using Phospho-CDK5 (Tyr15) antibody AP55874PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €270.00
  Acris Antibodies GmbH

CDK5 antibody

CDK5 Mouse IgG1 DC17+DC34 Purified Hu, Ms, Rt ICC/IF, IP, WB
1 ml / €690.00
  Acris Antibodies GmbH

CDK5 antibody

CDK5 Mouse IgG1 DC17+DC34 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.5 ml / €450.00
  Acris Antibodies GmbH

CDK5 antibody

CDK5 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CDK5 antibody

Western Blot analysis of CDK5 expression in transfected 293T cell line (H00001020-T02) by CDK5 MaxPab polyclonal antibody.

Lane 1: CDK5 transfected lysate(32.12 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

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