CDK6 antibody

Principal name

CDK6 antibody

Alternative names for CDK6 antibody

PLSTIRE, Cell division protein kinase 6, Serine/threonine-protein kinase PLSTIRE

SwissProt ID

Q00534 (Human), Q64261 (Mouse)

Gene ID

1021 (CDK6), 1021056 (Q8NU33), 12571 (Cdk6)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Background of CDK6 antibody

CDK6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.

General readings

1. Chilosi, M.; Doglioni, C.; Yan, Z.; Lestani, M.; Menestrina, F.; Sorio, C.; Benedetti, A.; Vinante, F.; Pizzolo, G.; Inghirami, G. : Differential expression of cyclin-dependent kinase 6 in cortical thymocytes and T-cell lymphoblastic lymphoma/leukemia. Am. J. Path. 152: 209-217, 1998.
2. Shennan, M. G.; Badin, A.-C.; Walsh, S.; Summers, A.; From, L.; McKenzie, M.; Goldstein, A. M.; Tucker, M. A.; Hogg, D.; Lassam, N. : Lack of germline CDK6 mutations in familial melanoma. Oncogene 19: 1849-1852, 2000.
3 Lien, H.-C.; Lin, C.-W.; Huang, P.-H.; Chang, M.-L.; Hsu, S.-M. : Expression of cyclin-dependent kinase 6 (cdk6) and frequent loss of CD44 in nasal-nasopharyngeal NK/T-cell lymphomas: comparison with CD56-negative peripheral T-cell lymphomas. Lab. Invest. 80: 893-900, 2000.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CDK6 antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 8H4 Purified Hu, Rt E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

CDK6 antibody

Immunoperoxidase of monoclonal antibody to CDK6 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml] Mouse IgG1 8H4 Purified Hu, Rt E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CDK6 antibody

Predicted band size: 37kDa.Positive control: Jurkat cell lysate.Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/300 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDK6 antibody

Predicted band size: 37 kDa . Positive control: Jurkat cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/150 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDK6 antibody

Predicted band size: 37 kDa . Positive control: HT29 and293 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1,2: HT29 and293 cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDK6 antibody

Western blot analysis of extracts of various cell lines, using CDK6 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CDK6 antibody

WB Suggested Anti-CDK6 Antibody Titration: 0.625ug/ml; Positive Control: Jurkat cell lysateCDK6 is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CDK6 antibody

CDK6 Mouse IgG1 DCS-83.1 Purified Hu C, IP, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

CDK6 antibody

Figure 1. Immunoprecipitation of CDK6 from Jurkat cells with AM20024AF-N (Lane 1) or Mouse IgG2a (Lane 2). After immunoprecipitated with the antibody, immunocomplex was resolved on SDS-PAGE and immunoblotted with AM20024AF-N. Mouse IgG2a DCS-130 Azide Free Hu ICC/IF, IP, P
0.1 mg / €300.00
  Acris Antibodies GmbH

CDK6 antibody

CDK6 Mouse IgG1 IML-6 Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CDK6 pTyr24 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using CDK6 (phospho-Tyr24) Antibody AP08040PU. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

CDK6 pTyr24 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using CDK6 (phospho-Tyr24) Antibody AP08040PU. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

CDK6 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using CDK6 Antibody AP08101PU. Rabbit Aff - Purified Hu, Ms ICC/IF, P
0.1 ml / €270.00
  Acris Antibodies GmbH

CDK6 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using CDK6 Antibody AP08101PU. Rabbit Aff - Purified Hu, Ms ICC/IF, P
50 µl / €230.00
  Acris Antibodies GmbH

CDK6 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using CDK6 Antibody AP08102PU. Rabbit Aff - Purified Hu, Ms P
0.1 ml / €270.00
  Acris Antibodies GmbH

CDK6 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using CDK6 Antibody AP08102PU. Rabbit Aff - Purified Hu, Ms P
50 µl / €230.00
  Acris Antibodies GmbH

CDK6 pTyr13 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CDK6 pTyr13 Antibody (#AP09488PU). Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

CDK6 pTyr13 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CDK6 pTyr13 Antibody (#AP09488PU). Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

CDK6 antibody

CDK6 Mouse IgG1 DCS-83 Purified Hu C, ICC/IF, IP, P, WB
0.1 mg / €240.00
  Acris Antibodies GmbH

CDK6 antibody

Figure 1. Western blot analysis of CDK6 expression in HeLa cells (A), Rat-1 cells (B-1) and NIH/3T3 cells (B-2) using CDK6 antibody (BM5021A). Mouse IgG1 DCS-83 Azide Free Hu, Ms, Rt IP, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

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