CDK9 antibody

Principal name

CDK9 antibody

Alternative names for CDK9 antibody

PITALRE, CDC2L4, Cell division protein kinase 9, Cyclin-dependent kinase 9, Serine/threonine-protein kinase PITALRE, Cell division cycle 2-like protein kinase 4

SwissProt ID

P50750 (Human), Q5EAB2 (Bovin), Q5ZKN1 (Chick), Q641Z4 (Rat), Q99J95 (Mouse)

Gene ID

1025 (CDK9), 107951 (Cdk9), 362110

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), African clawed frog

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CDK9 antibody

CDK9 (PITALRE) (also known as cyclin-dependent kinase 9, Serine/threonine-protein kinase PITALRE, C-2K and Cell division cycle 2-like protein kinase 4) is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2 and are known as important cell cycle regulators. CDK9 (PITALRE) interacts with a conserved domain in the TRAF-C region of the tumor necrosis factor signal transducer TRAF2. This kinase was also found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase IIdirected transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with, and is regulated by, its regulatory subunit, cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggests a possible involvement of this protein in AIDS. Tat stimulates human HIV-1 viral transcription elongation. This suggests that cyclin T1/CDK9(PITALRE) is one of the HIV-1 required host cellular cofactors generated during T cell activation. Cyclin T1/CDK9(PITALRE) has been shown to interact with Tat to restore Tat activation in HeLa nuclear extracts depleted of P-TEFb. CDK9(PITALRE) activity and cyclin T1 are essential for activation of viral transcription when tethered to the heterologous Rev response element RNA via the regulator of expression of virion Rev. CDK9 (PITALRE) is a ubiquitously expressed nuclear protein. CDK9 kinase activity is regulated by autophosphoryaltion of CDK9 at T29 and T186. T29 phosphorylation is uniquely induced by the HTLV-1 viral oncoprotein Tax.

General readings

Li,Q., (2005) J. Biol. Chem. 280 (31), 28819-28826

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CDK9 antibody

Immunohistochemical analysis of paraffin-embedded brain tissues (left) and esophageal cancer tissues (right) using CDK9 mouse mAb with DAB staining. Mouse IgG1 1B5A7 Ascites Hu E, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

CDK9 antibody

  Rabbit polyclonal anti-Cdk9 antibody  
anti cdk9 antibody (TA319415 1:1500 ) was used for Western blot analysis of 1) PC3 and 2) DU145 prostate cancer cells (50ug per lane). Bands at the expected MW of 55 and 42 Kda were detected. Personal communication Flavio Rizzolio, Temple University Rabbit Serum Hu, Ms, Rt C, E, ICC/IF, P, WB
0.1 ml / €356.00
  OriGene Technologies, Inc.

CDK9 antibody

  Rabbit polyclonal CDK9 phospho T29 antibody (Phospho-specific)  
CDK9 Rabbit IgG Purified Hu, Ms, Rt E, IP, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

CDK9 antibody

  Anti-CDK9 Rabbit Polyclonal Antibody  
Predicted band size: 53 kDa . Positive control: 823 and Hela cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lane1: 823 cell lysate Lane2: Hela cell lysate Lysates: 40 ug Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 40 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDK9 antibody

  Rabbit Polyclonal Anti-CDK9 Antibody  
WB Suggested Anti-CDK9 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Transfected 293T Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CDK9 antibody

  Rabbit Polyclonal Anti-CDK9 Antibody  
WB Suggested Anti-CDK9 Antibody; Titration: 2.5 ug/ml; Positive Control: Transfected 293T Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CDK9 antibody

  Rabbit anti-CDK9 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using CDK9 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CDK9 antibody

Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues (left) and rectum cancer tissues (right) using CDK9 mouse mAb with DAB staining. Mouse IgG1 1B5D10 Ascites Hu E, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

CDK9 antibody

Skin: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Hu E, IP, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CDK9 antibody

CDK9 Rabbit Serum Hu, Ms, Rt C, E, IP, P, WB
0.1 ml / €520.00
  Acris Antibodies GmbH

CDK9 pThr186 antibody

Western blot analysis of extracts from NIH-3T3 cells treated with Forskolin 40nM 30', using CDK9 (Phospho-Thr186) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

CDK9 pThr186 antibody

Western blot analysis of extracts from NIH-3T3 cells treated with Forskolin 40nM 30', using CDK9 (Phospho-Thr186) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

CDK9 - human gene knockout kit via CRISPR

CDK9 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CDK9 - human gene knockout kit via CRISPR

CDK9 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CDK9 - human gene knockout kit via CRISPR

CDK9 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cdk9 - mouse gene knockout kit via CRISPR

Cdk9 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cdk9 - mouse gene knockout kit via CRISPR

Cdk9 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cdk9 - mouse gene knockout kit via CRISPR

Cdk9 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cdk9 - mouse gene knockout kit via CRISPR

Cdk9 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CDK9 (mGFP-tagged) - Human cyclin-dependent kinase 9 (CDK9), 200 uL, >10^7 TU/mL

Lenti ORF particles, CDK9 (mGFP-tagged) - Human cyclin-dependent kinase 9 (CDK9), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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