CDKN2C / p18INK4c antibody

Principal name

CDKN2C / p18INK4c antibody

Alternative names for CDKN2C / p18INK4c antibody

p18-INK4c, p18-INK6, p18INK6, CDKN6, Cyclin-dependent kinase 4 inhibitor C, Cyclin-dependent kinase 6 inhibitor

SwissProt ID

P42773 (Human), Q60772 (Mouse)

Gene ID

1031 (CDKN2C)

Available reactivities

Hu (Human), Ms (Mouse), Mky (Monkey), Rt (Rat), Can (Canine)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E)

Background of CDKN2C / p18INK4c antibody

Regulation of the cell cycle is in part mediated by the activity of the INK4 family of proteins. p18, INK4c, along with the closely related protein p19 is responsible for regulation of the activity of both cdk4 and cdk6 thereby regulating the G1→S transition. p18 functions to block the phosphorylation of the cdk proteins by CAK (MO15). Mapping to chromosome 1p32 in humans, p18 is composed of 3 exons spanning 7.5 kb of DNA with 5 kb of promoter sequence. A major cytoplasmic phosphoprotein that undergoes changes in phosphorylation in response to differentiation signals as well as cell cycle signals, p18 also appears to play a major role in controlling differentiation as well as in the maintenance of the differentiated state and the transformed phenotype. Although chromosome 1 is frequently involved in various cancers, there is no or very little evidence for deletions, rearrangements, or mutation of the p18 gene in neuroblastomas, osteosarcomas, non-small cell lung cancer, B-cell non-Hodgkin's lymphoma, ALL, or pancreatic cancers. INK4c deficient mice however will progress over time from pituitary hyperplasia to adenoma.

General readings

General / background references:Khleif SN et al. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci U S A 93:4350-4 (1996). PubMed PMID: 8633069
Lapointe J et al. A p18 mutant defective in CDK6 binding in human breast cancer cells. Cancer Res 56:4586-9 (1996). PubMed PMID: 8840966
Palmero I & Peters G Perturbation of cell cycle regulators in human cancer. Cancer Surv 27:351-67 (1996). PubMed PMID: 8909810

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CDKN2C / p18INK4c antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-CDKN2C rabbit polyclonal antibody. (TA590417) Rabbit IgG Purified Can, Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CDKN2C / p18INK4c antibody

Western blot analysis of extracts from COS7 cells, using p18 INK antibody (#TA313181).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDKN2C / p18INK4c antibody

CDKN2C / p18INK4c Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CDKN2C / p18INK4c antibody

Western blot analysis of p18 INK expression in Cos7 cell extract Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CDKN2C / p18INK4c antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2C (RC213083, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2C. Mouse IgG2b OTI2E1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDKN2C / p18INK4c antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2C (RC213083, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2C. Mouse IgG1 OTI6D3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDKN2C / p18INK4c antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2C (RC213083, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2C. Mouse IgG1 OTI1E4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDKN2C / p18INK4c antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2C (RC213083, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2C. Mouse IgG1 OTI6B3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDKN2C / p18INK4c antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2C (RC213083, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2C. Mouse IgG1 OTI2D7 Purified Hu WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CDKN2C / p18INK4c antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2C (RC213083, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2C. Mouse IgG1 OTI1C12 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDKN2C / p18INK4c antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2C (RC213083, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2C. Mouse IgG1 OTI1H1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDKN2C / p18INK4c antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2C (RC213083, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2C. Mouse IgG1 OTI4G10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDKN2C / p18INK4c antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKN2C (RC213083, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKN2C. Mouse IgG2a OTI5G1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDKN2C / p18INK4c antibody

Figure 3. AM00301AF-N p18INK4c antibody Staining of Paraffin Embedded Human Tonsil Section (germinal center). Mouse IgG2a DCS-118 Azide Free Hu IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CDKN2C / p18INK4c antibody

Figure 1. AM12104PU-N p18INK4c antibody staining of Formalin-Fixed, Paraffin-Embedded Human Tonsil using peroxidase-conjugate and AEC chromogen. Note nuclear staining of cells. Mouse IgG2a DCS118 Purified Hu P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CDKN2C / p18INK4c antibody

Immunohistochemistry (IHC) analysis of p18 INK antibody (Cat.-No.: AP06262PU-N) in paraffin-embedded human breast carcinoma tissue Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CDKN2C / p18INK4c antibody

Immunofluorescence of purified MaxPab antibody to CDKN2C on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

CDKN2C / p18INK4c antibody

CDKN2C / p18INK4c Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

CDKN2C / p18INK4c antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using p18 INK Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
50 µg / €205.00
  Assay Biotech

CDKN2C / p18INK4c antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using p18 INK Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €310.00
  Assay Biotech

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