CDw210a / IL10RA antibody

Principal name

CDw210a / IL10RA antibody

Alternative names for CDw210a / IL10RA antibody

Interleukin-10 receptor alpha chain, IL-10R-A, IL10 Receptor alpha

SwissProt ID

Q13651 (Human), Q61727 (Mouse)

Gene ID

3587 (IL10RA), 16154 (Il10ra)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rat, Mouse, Goat, Rabbit, Hamster

Available applications

Functional assay (FN), Flow Cytometry (F), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), ELISA (detection) (E(detection)), Neutralisation (NEUT)

Background of CDw210a / IL10RA antibody

Interleukin 10, initially named cytokine synthesis inhibitory factor (CSIF), is a potent immunosuppressant of macrophage functions. IL10, a pleiotropic cytokine, exerts either immunostimulatory or immunosuppressive effects on a number of cell types, including Thy2 cells, activated fetal thymocytes, macrophages, keratinocytes, and LY-1 (CD5+) and normal B cells. IL10 stimulates the growth of stem cells, mast cells, and thymocytes and also enhances cytotoxic T cell development, costimulates B cell differentiation, and immunoglobulin secretion. Interleukin 10 binds specifically and with high affinity to cell-surface receptors. Interleukin 10 receptors are members of the class II subgroup of the cytokine receptor superfamily. Mouse and human cDNA clones encoding the ligand binding IL10 receptor have been isolated. The IL10 receptor complex contains two distinct type II cytokine receptor subunits, the ligand binding IL10RA and the IL10RB. The coexpression of both chains is essential for IL10 induced signal transduction. The beta chain serves as an accessory chain essential for the active IL10 receptor complex and necessary for the initiation of signal transdunction. Interleukin 10 receptors are expressed in all cell types that are known to respond to IL10. The human interleukin 10 receptor gene maps to chromosome 11q23.3.7

General readings

1. Liu. Y. et al. (1997). The EBV-10 homologue is a selective agonist with impaired binding to the IL-10 receptor. J. Immunol. 158: 604 - 613.
2. O'Farrell. A. et al. (1998). IL-10 inhibits macrophage activation and proliferation by distinct mechanisms: evidence for stat 3 - dependent and-independent pathways. EMBO J. 17:
1006 - 1018
3. Corinti. S. et al. (2001). Regulatory activity of autocrine IL-10 on dendritic cell functions. J. Immunol. 166: 4312 - 4318.
4. Elbim. C. et al. (2001). Intracellular pool of IL-10 receptors in specific granules of human neutophils: Differential mobilization by proinflammatory mediators. J. Immunol. 166:
5201 - 5207.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CDw210a / IL10RA antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-IL10RA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506929) Mouse IgG1 OTI1D10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDw210a / IL10RA antibody

Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human tonsil and lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using IL10RA antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDw210a / IL10RA antibody

Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human tonsil tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using IL10RA antibody at dilution 1/60, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDw210a / IL10RA (Center) antibody

Western blot analysis of IL10RA Antibody (Center) (Cat. #TA325071) in MCF-7 cell line lysates (35ug/lane). IL10RA (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CDw210a / IL10RA antibody

Western blot analysis of IL-10R alpha expression in Na2VO3 treated HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CDw210a / IL10RA antibody

Anti-IL10RA mouse monoclonal antibody (TA506928) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IL10RA(RC207020). Mouse IgG1 OTI1E5 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDw210a / IL10RA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL10RA (RC207020, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL10RA. Mouse IgG1 OTI1C7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDw210a / IL10RA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL10RA (RC207020, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL10RA. Mouse IgG1 OTI1D8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDw210a / IL10RA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL10RA (RC207020, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL10RA. Mouse IgG1 OTI1C12 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDw210a / IL10RA antibody

Anti-IL10RA mouse monoclonal antibody (TA506934) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IL10RA(RC207020). Mouse IgG1 OTI1D4 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDw210a / IL10RA antibody

Anti-IL10RA mouse monoclonal antibody (TA506955) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY IL10RA(RC207020). Mouse IgG1 OTI1G10 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CDw210a / IL10RA antibody

Western blot analysis of IL-10Rα antibody (AP20308PU-N) in extracts from HepG2 cells. Rabbit Aff - Purified Hu ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CDw210a / IL10RA pSer319/323 antibody

CDw210a / IL10RA Rabbit Aff - Purified Hu WB
0.1 ml / €320.00
  Acris Antibodies GmbH

CDw210a / IL10RA pSer319/323 antibody

CDw210a / IL10RA Rabbit Aff - Purified Hu WB
50 µl / €240.00
  Acris Antibodies GmbH

CDw210a / IL10RA pTyr496 antibody

Western blot analysis of extracts HUVEC tissue using IL-10R alpha (Phospho-Tyr496) antibody AP55878PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu WB
0.1 ml / €340.00
  Acris Antibodies GmbH

CDw210a / IL10RA pTyr496 antibody

Western blot analysis of extracts HUVEC tissue using IL-10R alpha (Phospho-Tyr496) antibody AP55878PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu WB
50 µl / €270.00
  Acris Antibodies GmbH

CDw210a / IL10RA (Extracell. Dom.) antibody

CDw210a / IL10RA Hamster IgG2 9E12 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CDw210a / IL10RA antibody

CDw210a / IL10RA Rat IgG2a 3F9 Azide Free Hu F, FN
1 mg / €810.00
  Acris Antibodies GmbH

CDw210a / IL10RA antibody

CDw210a / IL10RA Rat IgG2a 3F9 Purified Hu F
0.1 mg / €310.00
  Acris Antibodies GmbH

CDw210a / IL10RA antibody

CDw210a / IL10RA Rat IgG2a 3F9 Purified Hu F
0.2 mg / €490.00
  Acris Antibodies GmbH

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