Ceramide Kinase antibody

Principal name

Ceramide Kinase antibody

Alternative names for Ceramide Kinase antibody

hCERK, Acylsphingosine kinase, Lipid kinase 4, KIAA1646, LK4

SwissProt ID

Q8K4Q7 (Mouse), Q8TCT0 (Human)

Gene ID

64781 (CERK)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Eq (Equine), Rt (Rat), Mky (Monkey), Prim (Primate), Bear

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of Ceramide Kinase antibody

Sphingolipids, in addition to being structural components of membranes, regulate cell-cell and cell-substrate interactions, proliferation, and differentiation. Members of this diverse group of lipids have emerged as a novel class of signaling molecules that also regulate phagocytosis. The mechanisms by which sphingolipids exert these effects remain incompletely defined. More than a decade ago, it was found that ceramide can be phosphorylated to ceramide 1-phosphate (C1P). Ceramide kinase (CERK) and its phosphorylated product ceramide 1-phosphate (C1P) are central players in inflammation and cancer. The product of CERK activity, ceramide 1-phosphate (C1P), has been reported to have mitogenic effects. C1P is a direct activator of cytosolic phospholipase A2 and is involved in arachidonic acid release. CERK is a mediator of Ca2+-dependent degranulation in mast cells. In both arachidonic acid release and mast cell degranulation, the intracellular elevation of Ca2+ is a central event that acts as a regulatory mechanism of CERK activity. C1P is found in brain synaptic vesicles, and plays a role in regulating the secretion of neurotransmitters. CERK activity exists in HL-60 cells where the C1P is derived from ceramide released from sphingomyelin. The expressed kinase has specific ceramide phosphorylating activity. CERKs exist in a variety of cellular organisms, including plants, nematodes, insects, and vertebrates.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ceramide Kinase antibody

  Rabbit Polyclonal Antibody against Ceramide Kinase  
Detection of Ceramide Kinase in A549 cell lysate Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Ceramide Kinase antibody

  Rabbit Polyclonal Anti-CERK Antibody  
Host: Rabbit; Target Name: CERK; Sample Tissue: 721_B Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Can, Eq, Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Ceramide Kinase antibody

  Rabbit Polyclonal Anti-CERK Antibody (Internal)  
Ceramide Kinase Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

Ceramide Kinase (N-term, Extracel. Dom.) antibody

  Rabbit Polyclonal Anti-CERK Antibody (N-Terminus)  
Ceramide Kinase Rabbit Aff - Purified Bear, Can, Hu, Mky, Prim P
50 µg / €400.00
  OriGene Technologies, Inc.

Ceramide Kinase antibody

Ceramide Kinase Rabbit Purified Hu E, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Ceramide Kinase (C-term) antibody

The anti-CERK Pab is used in Western blot to detect CERK in mouse heart tissue lysate (Lane 1) and A2058 cell lysate (Lane 2). Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CERK - human gene knockout kit via CRISPR

CERK - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CERK - human gene knockout kit via CRISPR

CERK - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CERK - human gene knockout kit via CRISPR

CERK - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CERK - human gene knockout kit via CRISPR

CERK - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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