Chemokine receptor-like 1 antibody

Principal name

Chemokine receptor-like 1 antibody

Alternative names for Chemokine receptor-like 1 antibody

CMKLR1, CHEMR23, DEZ, G-protein coupled receptor DEZ, G-protein coupled receptor ChemR23

SwissProt ID

O35786 (Rat), P97468 (Mouse), Q99788 (Human)

Gene ID

1240 (CMKLR1), 14747 (Cmklr1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Prim (Primate), Por (Porcine), Mky (Monkey), Rb (Rabbit)

Available hosts

Rat, Rabbit, Mouse

Available applications

Flow Cytometry (F), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP)

Background of Chemokine receptor-like 1 antibody

The BZ332 antibody reacts with human chemokine-like receptor 1, CMKLR1. CMKLR1 (also known as ChemR23 or DEZ), is a recently-described serpentine chemoattractant receptor. CMKLR1 has been shown to be expressed by dendritic cells (DC) generated in vitro from monocytes, and to mediate their migration to the proteolytically regulated chemoattractant chemerin. CMKLR1 is expressed by circulating DCs in human blood. Importantly, it is selectively expressed by immature plasmacytoid DCs, but not myeloid DCs, thus ebling discrimition between these two dendritic cell lineages. While CMKLR1 is expressed by circulating pDCs in human blood, mDCs, as well as lymphocytes, monocytes, neutrophils, and eosinophils are negative. Human serum contains a chemoattractant for CMKLR1 which is identical with chemerin; this activity is triggered during blood coagulation, suggesting a mechanism for attraction of pDCs to sites of tissue damage and bleeding. Expression of CMKLR1 and migration to locally activated chemerin may allow the rapid and differential recruitment of pDCs in vivo. Unlike mDCs, circulating pDCs do not respond to inflammatory chemokines.

General readings

1. Bauer S  et al. Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes. Endocrinology 152:26-35 (2011). WB ; Mouse .
2. Campbell EL  et al. Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification. Proc Natl Acad Sci U S A 107:14298-303 (2010).
3. Sell H  et al. Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes 58:2731-40 (2009). WB ; Human .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Chemokine receptor-like 1 (N-term) antibody

  Rabbit Polyclonal Anti-CMKLR1 Antibody (N-Terminus)  
Anti-CMKLR1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

Chemokine receptor-like 1 antibody

  Rabbit polyclonal anti-CMKLR1 antibody  
Western blot analysis of extracts from HepG2 cells, HeLa cells and 293 cells, using CMKLR1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Chemokine receptor-like 1 antibody

  Rat Anti-Mouse CMKLR1 Purified (50 ug)  
Staining of resident mouse peritoneal macrophages with 0.25 ug/ml of Rat IgG2a K Isotype Control Purified (open histogram) or 0.25 ug/ml of Anti-Mouse CMKLR1 Purified (filled histogram) followed by F(ab')2 Anti-Rat IgG PE .  Total viable cells were used for analysis. Rat BZ194 (194) Purified Ms F
50 µg / €120.00
  OriGene Technologies, Inc.

Chemokine receptor-like 1 antibody

  Rat Anti-Human CMKLR1 Purified (25 ug)  
Chemokine receptor-like 1 Rat BZ332 Purified Hu F
25 µg / €150.00
  OriGene Technologies, Inc.

Chemokine receptor-like 1 antibody

  Rabbit Polyclonal Anti-CMKLR1 Antibody  
WB Suggested Anti-CMKLR1 Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Chemokine receptor-like 1 antibody

  Rabbit Polyclonal Anti-CMKLR1 Antibody (C-Terminus)  
Anti-CMKLR1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky, Rb
50 µg / €400.00
  OriGene Technologies, Inc.

Chemokine receptor-like 1 (N-term) antibody

Chemokine receptor-like 1 Rat IgG2a BZ332 FITC Hu F
0.1 mg / €420.00
  Acris Antibodies GmbH

Chemokine receptor-like 1 antibody

Chemokine receptor-like 1 Rat IgG2a BZ332 FITC Hu F
25 µg / €190.00
  Acris Antibodies GmbH

Chemokine receptor-like 1 antibody

Chemokine receptor-like 1 Rat IgG2a BZ332 Purified Hu F
0.2 mg / €500.00
  Acris Antibodies GmbH

Chemokine receptor-like 1 (N-term) antibody

Chemokine receptor-like 1 Rat IgG2a BZ332 Purified Hu F
0.1 mg / €320.00
  Acris Antibodies GmbH

Chemokine receptor-like 1 antibody

Immunohistochemistry on paraffin sections: AM26720PU-N on Human placenta. Mouse IgG2b 1A7 Purified Hu P
0.1 mg / €390.00
  Acris Antibodies GmbH

Chemokine receptor-like 1 antibody

Western blot analysis of ChemR23 antibody Cat.-No AP06779PU-N at 1/500 dilution in Jurkat Cell Lysate (Lane 1), Mouse Liver Tissue Lysate (Lane 2) and Rat Liver Tissue Lysate (Lane 3). Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Chemokine receptor-like 1 (N-term, Extracell. Dom.) antibody

Staining of Thymus, using SP4100P (paraffin embedded section). Rabbit Aff - Purified Hu, Prim ICC/IF, P
50 µg / €470.00
  Acris Antibodies GmbH

Chemokine receptor-like 1 antibody

Western blot analysis of extracts from HeLa/HuvEc cells, using CMKLR1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

Chemokine receptor-like 1 antibody

Western blot analysis of extracts from HeLa/HuvEc cells, using CMKLR1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

CMKLR1 - human gene knockout kit via CRISPR

CMKLR1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CMKLR1 - human gene knockout kit via CRISPR

CMKLR1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CMKLR1 - human gene knockout kit via CRISPR

CMKLR1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CMKLR1 - human gene knockout kit via CRISPR

CMKLR1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cmklr1 - mouse gene knockout kit via CRISPR

Cmklr1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

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