CHK2 antibody

Principal name

CHK2 antibody

Alternative names for CHK2 antibody

CHEK2, CHEK-2, CHK-2, RAD53, Cds1, Serine/threonine-protein kinase Chk2, CHK2 checkpoint homolog

SwissProt ID

O96017 (Human), Q9U1Y5 (Caeel), Q9UGF0 (Human), Q9Z265 (Mouse)

Gene ID

11200 (CHEK2), 50883 (Chek2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chimp (Chimpanzee), Mky (Monkey), Por (Porcine), Can (Canine), Bov (Bovine)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), EPair for Elisa (EPair), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Flow Cytometry (F), Luminex (LMNX), Frozen Sections (C)

Background of CHK2 antibody

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, CHEK2 is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in its gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in its gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases.In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.

General readings

Clone DCS-273 is used in these references:
1. Syljuäsen, R.G., et al., Cancer Res. 66, 10253-10257 (2006)
2. Berger, M., et al., Mol. Cell Biol. 25, 5380-5388 (2005)
3. Latella, L., et al., Mol. Cell Biol. 24, 6350-6361 (2004)
4. Louria-Hayon, I., et al., J. Biol. Chem. 278, 33134-33141 (2003)
5. Lukas, C., et al., Cancer Res. 61, 4990-4993 (2001)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CHK2 antibody

  CHEK2 (CHK2) mouse monoclonal antibody, clone OTI2F4 (formerly 2F4)  
Immunofluorescent staining of HT29 cells using anti-CHEK2 mouse monoclonal antibody (TA500405). Mouse IgG2b OTI2F4 Purified Can, Hu, Mky, Rt F, ICC/IF, WB
0.1 ml / €350.00
  OriGene Technologies, Inc.

TrueMAB

CHK2 (N-term) antibody

  Rabbit Polyclonal Chk2 Antibody  
Western blot analysis of Chk2 expression in K562 (A), Jurkat (B), and HL-60 (C) whole cell lysates with Chk2 antibody at 1 ug /ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €371.00
  OriGene Technologies, Inc.

CHK2 antibody

  Rabbit polyclonal Chk2 (Thr387) antibody(Phospho-specific)  
Western blot analysis of extracts from Jurkat cells, using Chk2 (Phospho-Thr387) Antibody (#TA312767).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

CHK2 antibody

  Rabbit polyclonal Chk2 (Thr383) antibody(Phospho-specific)  
Western blot analysis of extracts from COS7 cells, treated with UV (30mins), using Chk2 (Phospho-Thr383) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

CHK2 antibody

  Rabbit polyclonal Chk2 (Thr68) antibody(Phospho-specific)  
Western blot analysis of the extracts from Jurkat cells untreated or treated with UV using Chk2 (Ab-68) Antibody and Chk2 (Phospho-Thr68) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

CHK2 antibody

  Rabbit polyclonal Chk2 (Ab-68) antibody  
Western blot analysis of extracts from Jurkat and HeLa cells treated with etoposide 25uM 24hours, using Chk2 (Ab-68) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

CHK2 antibody

  Anti-CHEK2 Rabbit Polyclonal Antibody  
Predicted band size: 61kDa. Positive control: 293T , Hela and HT-29 cell lysate . Recommended dilution: 1/200-1000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

CHK2 antibody

  Rabbit Polyclonal Chk2 Antibody  
Western blot analysis of Chk2 expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

CHK2 antibody

  CHEK2 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using CHEK2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €335.00
  OriGene Technologies, Inc.

CHK2 pThr68 antibody

Figure 2. Immunohistochemistry (IHC) analyzes of p-Chk2 antibody (pThr68) in paraffin-embedded human breast carcinoma tissue.  (Cat.-No.: AP01556PU-N) Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CHK2 pThr68 antibody

CHK2 Rabbit IgG Purified Hu, Mky, Ms, Rt E, WB
50 µg / €370.00
  Acris Antibodies GmbH

CHK2 antibody

Immunohistochemical analysis in paraffin-embedded human breast carcinoma tissue using CHK2 antibody (Cat.-No. AP06052PU-N). Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CHK2 antibody

Immunohistochemistry (IHC) analyzes of Chk2 antibody (Cat.-No.: AP06380PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CHK2 pSer379 antibody

Western blot (WB) analysis of Chk2 antibody (Cat.-No.: AP06512PU-N) in extracts from COS7 cells treated with UV 30'. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CHK2 antibody

Testis: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µg / €380.00
  Acris Antibodies GmbH

CHK2 pThr387 antibody

Immunohistochemistry (IHC) analyzes of p-CHK2 (pThr387) antibody (Cat.-No.: AP20931PU-N) in paraffin-embedded human lung adenocarcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

CHK2 pThr68 antibody

CHK2 Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

CHK2 antibody

CHK2 Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

CHK2 antibody

CHK2 Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

CHK2 (C-term) antibody

CHK2 Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €390.00
  Acris Antibodies GmbH

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